Toward a unified picture of the exocytotic fusion pore. [PDF]
FEBS Lett, 2018 Neurotransmitter and hormone release involve calcium‐triggered fusion of a cargo‐loaded vesicle with the plasma membrane. The initial connection between the fusing membranes, called the fusion pore, can evolve in various ways, including rapid dilation to
Karatekin E.
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The complexin C-terminal amphipathic helix stabilizes the fusion pore open state by sculpting membranes. [PDF]
Nat Struct Mol Biol, 2022 Courtney KC +14 more
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Chromogranin A, the major lumenal protein in chromaffin granules, controls fusion pore expansion. [PDF]
J Gen Physiol, 2019 Upon fusion of the secretory granule with the plasma membrane, small molecules are discharged through the immediately formed narrow fusion pore, but protein discharge awaits pore expansion.
Abbineni PS +3 more
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Arginine-rich cell-penetrating peptides induce membrane multilamellarity and subsequently enter via formation of a fusion pore. [PDF]
Proc Natl Acad Sci U S A, 2018 Significance The passive translocation mechanism of arginine-rich cell-penetrating peptides has puzzled the scientific community for more than 20 y. In this study we propose a hitherto unrecognized mechanism of passive cell entry involving fusion of ...
Allolio C +14 more
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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2003 The secretory process requires many different steps and stages. Vesicles must be formed and transported to the target membrane. They must be tethered or docked at the appropriate sites and must be prepared for fusion (priming). As the last step, a fusion pore is formed and the contents are released.
Lindau, M., de Toledo, A.
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Differential SNARE chaperoning by Munc13-1 and Munc18-1 dictates fusion pore fate at the release site [PDF]
Nature CommunicationsThe regulated release of chemical messengers is crucial for cell-to-cell communication; abnormalities in which impact coordinated human body function. During vesicular secretion, multiple SNARE complexes assemble at the release site, leading to fusion ...
Bhavya R. Bhaskar +7 more
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Excess cholesterol inhibits glucose-stimulated fusion pore dynamics in insulin exocytosis. [PDF]
J Cell Mol Med, 2017 Type 2 diabetes is caused by defects in both insulin sensitivity and insulin secretion. Glucose triggers insulin secretion by causing exocytosis of insulin granules from pancreatic β‐cells. High circulating cholesterol levels and a diminished capacity of
Xu Y, Toomre DK, Bogan JS, Hao M.
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Phases of the exocytotic fusion pore [PDF]
FEBS Letters, 2018 Membrane fusion and fission are fundamental processes in living organisms. Membrane fusion occurs through the formation of a fusion pore, which is the structure that connects two lipid membranes during their fusion.
G. Álvarez de Toledo +3 more
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A Central Small Amino Acid in the VAMP2 Transmembrane Domain Regulates the Fusion Pore in Exocytosis. [PDF]
Sci Rep, 2017 Exocytosis depends on cytosolic domains of SNARE proteins but the function of the transmembrane domains (TMDs) in membrane fusion remains controversial.
Hastoy B +12 more
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Dynamin-2 Stabilizes the HIV-1 Fusion Pore with a Low Oligomeric State
Cell Reports, 2017 Summary: One of the key research areas surrounding HIV-1 concerns the regulation of the fusion event that occurs between the virus particle and the host cell during entry.
Daniel M. Jones +8 more
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