Results 181 to 190 of about 1,121,449 (385)

SKA1 promotes oncogenic properties in oral dysplasia and oral squamous cell carcinoma, and augments resistance to radiotherapy

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 1054-1074, April 2025.
The mitosis‐related gene SKA1 was among 629 genes consistently dysregulated in OSCC across nine public gene expression datasets. In OSCC cell lines, SKA1 promoted proliferation and migration, enhanced radioresistance, and reduced radiation‐induced senescence.
Alexander Michael Grandits   +7 more
wiley   +1 more source

Structure and function of a paramyxovirus fusion protein

open access: yesBiochimica et Biophysica Acta (BBA) - Biomembranes, 2003
Paramyxoviruses initiate infection by attaching to cell surface receptors and fusing viral and cell membranes. Viral attachment proteins, hemagglutinin-neuraminidase (HN), hemagglutinin (HA), or glycoprotein (G), bind receptors while fusion (F) proteins direct membrane fusion.
openaire   +3 more sources

NanoCMSer: a consensus molecular subtype stratification tool for fresh‐frozen and paraffin‐embedded colorectal cancer samples

open access: yesMolecular Oncology, Volume 19, Issue 5, Page 1332-1346, May 2025.
Consensus molecular subtypes (CMS1‐4) have been identified to study colorectal cancer heterogeneity and serve as potential biomarkers. In this study, we developed and evaluated NanoCMSer, a NanoString‐based classifier using 55 genes, optimized for FF and FFPE to facilitate the clinical evaluation of CMS subtyping.
Arezo Torang   +10 more
wiley   +1 more source

A Fusion-Driven Approach of Attention-Based CNN-BiLSTM for Protein Family Classification -- ProFamNet [PDF]

open access: yesarXiv
Advanced automated AI techniques allow us to classify protein sequences and discern their biological families and functions. Conventional approaches for classifying these protein families often focus on extracting N-Gram features from the sequences while overlooking crucial motif information and the interplay between motifs and neighboring amino acids.
arxiv  

MicroRNAs in seminal plasma are able to discern infertile men at increased risk of developing testicular cancer

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 1188-1202, April 2025.
Male infertility is a known risk factor for the development of testicular cancer. In this paper, we analyzed the expression profile of a microRNA panel by real‐time PCR and validated the results by digital PCR. Experimental and bioinformatics analyses allowed us to identify possible biomarkers able to discern men with a higher risk of developing ...
Carmen Ferrara   +14 more
wiley   +1 more source

Multi‐omics profiling reveals key factors involved in Ewing sarcoma metastasis

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 1002-1028, April 2025.
Using a mouse model that recapitulates the spread of tumor cells within the body, we have profiled paired tumors and metastasis samples using a multiomics approach combining different layers of biological information. We identified key genes that drive metastasis in Ewing sarcoma.
Mariona Chicón‐Bosch   +11 more
wiley   +1 more source

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