Results 221 to 230 of about 1,121,449 (385)

Fusion protein-based COVID-19 vaccines exemplified by a chimeric vaccine based on a single fusion protein (W-PreS-O). [PDF]

Front Immunol
Gattinger P, Kozlovskaya LI, Lunin AS, Gancharova OS, Sirazova DI, Apolokhov VD, Chekina ES, Gordeychuk IV, Karaulov AV, Valenta R, Ishmukhametov AA.   +10 more
europepmc   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Escherichia coli Fis and DnaA proteins bind specifically to the nrd promoter region and affect expression of an nrd-lac fusion [PDF]

, 1994
Lance B. Augustin, Bruce A. Jacobson, J A Fuchs   +2 more
openalex   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Mitochondrial fusion protein: a new therapeutic target for lung injury diseases. [PDF]

Front Physiol
Jia G, Song E, Huang Q, Chen M, Liu G.
europepmc   +1 more source

Epidermal growth factor receptor binding is affected by structural determinants in the toxin domain of transforming growth factor-alpha-Pseudomonas exotoxin fusion proteins.

, 1989
George M. Edwards, Deborah Defeo-Jones, J Y Tai, Gerald A. Vuocolo, Denis R. Patrick, David Heimbrook, Allen Oliff   +6 more
openalex   +1 more source

A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteins. [PDF]

, 1993
Sylvia Braselmann, Paula Graninger, Meinrad Busslinger   +2 more
openalex   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Establishment of an I-ELISA method based on multi-epitope fusion protein for diagnosis of human brucellosis. [PDF]

PLoS Negl Trop Dis
Xie Y, Guo L, Qi X, Zhao S, Pei Q, Chen Y, Wu Q, Yao M, Yin D.   +8 more
europepmc   +1 more source

Mutations in the fusion peptide and heptad repeat regions of the Newcastle disease virus fusion protein block fusion [PDF]

, 1994
T Sergel-Germano, Cathy McQuain, Trudy G. Morrison   +2 more
openalex   +1 more source