Results 21 to 30 of about 42,926,125 (284)

Lithocholic acid promotes skeletal muscle regeneration through the TGR5 receptor

Acta Biochimica et Biophysica Sinica, 2023
Lithocholic acid (LCA) is a classical secondary bile acid formed by the metabolism of gut microbiota. The TGR5 receptor (also known as G protein-coupled receptor 1, GPBAR1) is an important bile acid membrane receptor that mediates a variety of metabolic ...
Sun Lijuan, Li Fan, Tan Weihao, Zhao Weijie, Li Yongxiang, Zhu Xiaotong, Gao Ping, Shu Gang, Wang Songbo, Jiang Qingyan, Wang Lina   +10 more
doaj   +1 more source

Bile Acids Induce Neurite Outgrowth in Nsc-34 Cells via TGR5 and a Distinct Transcriptional Profile

Pharmaceuticals, 2023
Increasing evidence supports a neuroprotective role for bile acids in major neurodegenerative disorders. We studied major human bile acids as signaling molecules for their two cellular receptors, farnesoid X receptor (FXR or NR1H4) and G protein-coupled ...
Hayley D. Ackerman, Glenn S. Gerhard
doaj   +1 more source

Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis. [PDF]

, 2010
TGR5, the G protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways as well as bile homeostasis, and could therefore be involved in primary sclerosing cholangitis (PSC) a chronic inflammatory bile duct disease. We aimed to
Bergquist Annika, Melum, E., Andreas Teufel, Franke Andre, Ellinghaus Eva, Michael P. Manns, Benedicte A Lie, Stokkers, Pieter C. F., Stokkers, P.C.F., Weismueller, Tobias, Manns, M., Beuers Ulrich, Mathew, C., Keitel, V., Schramm Christoph, Bergquist, A., Weersma, R., Vatn, M., Christian Rust, Vatn, Morten H, Christoph Schramm, Hov, Johannes R, Stiehl Adolf, Ponsioen, C., Teufel, A., Rust Christian, Ponsioen, Cyriel Y, Henckaerts, L., Schrumpf, E., Erik Schrumpf, Balschun, T., Haeussinger, Dieter, Lie, B., Franke, Andre, Pieter C F Stokkers, Espen Melum, Annika Bergquist, Mathew, Christopher G, Melum, Espen, Spomer Lina, Boberg, K., Häussinger, D., Jon K. Laerdahl, null null, Daniel Gotthardt, Onnie Clive M., Franke, A., Beuers, U., Eva Ellinghaus, Wijmenga, Cisca, IBSEN Study Group, Laerdahl, J.K., Vatn, Morten H., Cisca Wijmenga, Gotthardt Daniel, Weersma, Rinse K., Hov Johannes R., Stokkers Pieter C. F., Beuers, Ulrich, Keitel Verena, Boberg Kirsten M., ElSharawy, Abdou, Mathew, Christopher G.; id_orcid, Vatn Morten H., Johannes R. Hov, Lie, Benedicte A., Häussinger, Dieter, Hov, J.R., Runz Heiko, Schrumpf Erik, Onnie, C.M., Liesbet Henckaerts, Vermeire, S., Weismüller, T., Teufel Andreas, Bergquist, Annika, Dieter Häussinger, Mathew Christopher G., Karlsen, T.H., Karlsen Tom H., Lie, B.A., Morten H Vatn, Keitel, Verena, Spomer, Lina, Onnie, C., Mathew, Christopher G., Stokkers, Pieter C F, Morten H. Vatn, Manns, Michael P, Weersma, R.K., ElSharawy Abdou, Jon K Laerdahl, Vermeire, Severine, Schreiber Stefan, Christopher G Mathew, Melum Espen, Tobias Weismüller, Henckaerts Liesbet, Onnie, Clive M., Tom H Karlsen, Ponsioen, C.Y., Ellinghaus, Eva, Manke Thomas, Onnie, Clive M, Runz, H., Schreiber, Stefan, Cyriel Y Ponsioen, Kirsten M. Boberg, Laerdahl, Jon K, Stokkers, P., Wijmenga, C., Wijmenga Cisca, Schreiber, S., Lina Spomer, Abdou ElSharawy, Lie, Benedicte A, Weersma, Rinse K, Stiehl, A., Stefan Schreiber, Severine Vermeire, Kirsten M Boberg, Adolf Stiehl, Weersma, Rinse K.; id_orcid, Schrumpf, Erik, Boberg, K.M., Stiehl, Adolf, Heiko Runz, Weismüller Tobias, Schramm, C., Sterneck, Martina, Gotthardt, D., Rinse K. Weersma, Ellinghaus, E., Boberg, Kirsten M., Verena Keitel, Spomer, L., Wijmenga, Cisca; id_orcid, Manke, Thomas, Elsharawy, A., Cyriel Y. Ponsioen, Schramm, Christoph, Vermeire Severine, Tobias Balschun, Karlsen, Tom H, Laerdahl, Jon K., Rust, C., Karlsen, T., Runz, Heiko, Manns Michael P., Laerdahl, J., Clive M Onnie, Teufel, Andreas, Martina Sterneck, Lie Benedicte A., Sterneck Martina, Häussinger Dieter, Christopher G. Mathew, Laerdahl Jon K., Weersma Rinse K., Mathew, C.G., Weismüller, Tobias, Henckaerts, Liesbet, Ponsioen, Cyriel Y., Boberg, Kirsten M, Benedicte A. Lie, Andre Franke, Sterneck, M., Ulrich Beuers, Thomas Manke, Vatn, M.H., Johannes R Hov, Ponsioen Cyriel Y., Manke, T., Karlsen, Tom H., Rinse K Weersma, Balschun Tobias, Pieter C. F. Stokkers, Balschun, Tobias, Hov, Johannes R., Hov, J., Tom H. Karlsen, Manns, Michael P., Manns, M.P., Michael P Manns, Gotthardt, Daniel, Rust, Christian, Clive M. Onnie   +186 more
core   +4 more sources

Bile acid receptors and gastrointestinal functions

Liver Research, 2019
Bile acids modulate several gastrointestinal (GI) functions including electrolyte secretion and absorption, gastric emptying, and small intestinal and colonic motility.
Alexander L. Ticho, Pooja Malhotra, Pradeep K. Dudeja, Ravinder K. Gill, Waddah A. Alrefai   +4 more
doaj   +1 more source

Systemic bile acid sensing by G protein‐coupled bile acid receptor 1 (GPBAR1) promotes PYY and GLP‐1 release [PDF]

British Journal of Pharmacology, 2013
Background and PurposeNutrient sensing in the gut is believed to be accomplished through activation of GPCRs expressed on enteroendocrine cells. In particular, L‐cells located predominantly in distal regions of the gut secrete glucagon‐like peptide 1 (GLP‐1) and peptide tyrosine‐tyrosine (PYY) upon stimulation by nutrients and bile acids (BA).
C, Ullmer, R, Alvarez Sanchez, U, Sprecher, S, Raab, P, Mattei, H, Dehmlow, S, Sewing, A, Iglesias, J, Beauchamp, K, Conde-Knape   +9 more
openaire   +2 more sources

The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?

Molecules, 2022
The G-protein-coupled bile acid receptor, Gpbar1 or TGR5, is characterized as a membrane receptor specifically activated by bile acids. A series of evidence shows that TGR5 induces protein kinase B (AKT), nuclear factor kappa-B (NF-κB), extracellular ...
Youchao Qi, Guozhen Duan, Dengbang Wei, Chengzhou Zhao, Yonggui Ma   +4 more
doaj   +1 more source

Research Progress on the Mechanism and Targeted Intervention of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1)-Mediated “Inflammation-Apoptosis-Metabolism-Microcirculation” Regulatory Network in Hepatitis B-Associated Liver Failure

Drug Design, Development and Therapy
Chao Cui,1 Yu Sun,2 Kaiyue Zhang,2 Jingfei Shi,3 Kai Wang,2,4 Shuai Gao4 1Scientific Research Department, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, People’s Republic of China; 2Department of Infectious Disease, Qilu Hospital of ...
Cui C, Sun Y, Zhang K, Shi J, Wang K, Gao S   +5 more
doaj   +1 more source

Recent advances in understanding bile acid homeostasis [version 1; referees: 2 approved]

F1000Research, 2017
Bile acids are derived from cholesterol to facilitate intestinal nutrient absorption and biliary secretion of cholesterol. Recent studies have identified bile acids as signaling molecules that activate nuclear farnesoid X receptor (FXR) and membrane G ...
John YL Chiang
doaj   +1 more source

Metabolic Effects of Bile Acids: Potential Role in Bariatric SurgerySummary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Bariatric surgery is the most effective and durable treatment for morbid obesity, with an unexplained yet beneficial side effect of restoring insulin sensitivity and improving glycemia, often before weight loss is observed.
Charles R. Flynn, Vance L. Albaugh, Naji N. Abumrad   +2 more
doaj   +1 more source

Intestinal Co-culture System to Study TGR5 Agonism and Gut Restriction

Bio-Protocol, 2021
The activation of the Takeda G-protein receptor 5 (TGR5, also known as the G protein-coupled bile acid receptor 1, GPBAR1) in enteroendocrine L-cells results in secretion of the anti-diabetic hormone Glucagon-Like Peptide 1 (GLP-1) into systemic ...
Snehal Chaudhari, Abigail Devlin
doaj   +1 more source