Results 31 to 40 of about 42,926,125 (284)

A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]

, 2010
This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Albert K. Groen, Hageman, Jurre, Herrema, H.J., Folkert Kuipers, Hageman, J., Kuipers, Folkert, Herrema, Hilde, Hilde Herrema, Kuipers, Folkert; id_orcid, Groen, A.K., Kuipers, F., Groen, Albert K., Jurre Hageman   +12 more
core   +1 more source

Discovery, optimization, and evaluation of non-bile acid FXR/TGR5 dual agonists

Scientific Reports, 2021
Although several potent bile acid Farnesoid X receptor (FXR) and Takeda G-protein-coupled receptor 5 (TGR5, GPBAR1) dual agonists such as INT-767 have been reported, no non-bile acid FXR/TGR5 dual agonist has been investigated to date.
Sachiho Miyata, Yuji Kawashima, Miku Sakai, Masaya Matsubayashi, Keisuke Motoki, Yui Miyajima, Yousuke Watanabe, Noriko Chikamatsu, Tetsuya Taniguchi, Ryukou Tokuyama   +9 more
doaj   +1 more source

The double-edged sword of probiotic supplementation on gut microbiota structure in Helicobacter pylori management

Gut Microbes, 2022
As Helicobacter pylori management has become more challenging and less efficient over the last decade, the interest in innovative interventions is growing by the day.
Ali Nabavi-Rad, Amir Sadeghi, Hamid Asadzadeh Aghdaei, Abbas Yadegar, Sinéad Marian Smith, Mohammad Reza Zali   +5 more
doaj   +1 more source

New synthetic bile acid analogue agonists of FXR and TGR5 receptors: Analytical methodologies for the study of their physico-chemical properties, pharmacokinetic activity and metabolism. [PDF]

, 2013
This thesis reports an integrated analytical approach for the study of physicochemical and biological properties of new synthetic bile acid (BA) analogues agonists of FXR and TGR5 receptors.
Colliva, Carolina <1981>
core   +1 more source

Bile acid metabolism and signaling in liver disease and therapy

Liver Research, 2017
Bile acids play a critical role in the regulation of glucose, lipid, and energy metabolism through activation of the nuclear bile acid receptor farnesoid X receptor (FXR) and membrane G protein-coupled bile acid receptor-1 (Gpbar-1, aka TGR5).
John Y.L. Chiang
doaj   +1 more source

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs [PDF]

, 2012
When it is difficult to develop selective ligands within a family of related G-protein-coupled receptors (GPCRs), chemically engineered receptors activated solely by synthetic ligands (RASSLs) are useful alternatives for probing receptor function. In the
Christiansen, Elisabeth, Tikhonova, I.G., Ulven, T., Hudson, B., Tikhonova, Irina G, Adams, D.R., Grundmann, Manuel, Milligan, Graeme, Hudson, Brian D, Christiansen, E., Kostenis, Evi, Kostenis, E., Adams, David R, Milligan, G., Tikhonova, Irina G; id_orcid, Ulven, Trond, Grundmann, M.   +16 more
core   +1 more source

GPCR-OKB: the G protein coupled receptor oligomer knowledge base [PDF]

, 2010
Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically.
Bas Vroling, Pin, J.-P., Palczewski, K., Camacho-Artacho, Marta, Pin, J.P., Lucy Skrabanek, Jean-Philippe Pin, Marta Camacho-Artacho, Devi, Lakshmi A, Graeme Milligan, Marta Filizola, Campagne, Fabien, Fabien Campagne, Martin J. Lohse, Jufang Shan, Lohse, Martin J, Vriend, Gerrit, Khelashvili, George, Milligan, Graeme, Camacho-Artacho, M., Skrabanek, L., George Khelashvili, Campagne, F., Susan R. George, Lakshmi A. Devi, Filizola, M., Pin, Jean-Philippe, Vroling, B., Bouvier, M., Devi, L.A., Richard R. Neubig, Marc Parmentier, George, Susan R, Palczewski, Krzysztof, Dorff, K., Shan, J., Vriend, G., Michel Bouvier, Lohse, M.J., Bouvier, Michel, Skrabanek, Lucy, Vroling, Bas, Filizola, Marta, Neubig, Richard R, Gerrit Vriend, Dorff, Kevin, Parmentier, Marc, Khelashvili, G., Javitch, J.A., Shan, Jufang, Parmentier, M., Javitch, Jonathan A, Krzysztof Palczewski, Kevin Dorff, Jonathan A. Javitch, George, S.R., Neubig, R.R., Milligan, G.   +57 more
core   +3 more sources

Gut microbiota regulates postprandial GLP-1 response via ileal bile acid-TGR5 signaling

Gut Microbes, 2023
The gut microbiota interacts with intestinal epithelial cells through microbial metabolites to regulate the release of gut hormones. We investigated whether the gut microbiota affects the postprandial glucagon-like peptide-1 (GLP-1) response using ...
Qiaoling Wang, Huibin Lin, Chongrong Shen, Minchun Zhang, Xingyu Wang, Miaomiao Yuan, Mingyang Yuan, Sheng Jia, Zhiwen Cao, Chao Wu, Banru Chen, Aibo Gao, Yufang Bi, Guang Ning, Weiqing Wang, Jiqiu Wang, Ruixin Liu   +16 more
doaj   +1 more source

The role of 11β-hydroxysteroid dehydrogenase type 1 in bile acid homeostasis [PDF]

, 2013
Bile acids (BAs) are important modulators of metabolic functions such as lipid, triglyceride and glucose homeostasis. Intrahepatic accumulation of BAs is known to cause liver injury in cholestatic conditions, where normal trans-hepatic BA flow is ...
Penno, Carlos Alberto
core   +1 more source

Bile Acids Activated Receptors in Inflammatory Bowel Disease

Cells, 2021
Once known exclusively for their role in nutrients absorption, bile acids have emerged as signaling molecules, generated from cholesterol breakdown, acting on several immune cells by activating a variety of receptors including the G protein-coupled bile ...
Michele Biagioli, Silvia Marchianò, Adriana Carino, Cristina Di Giorgio, Luca Santucci, Eleonora Distrutti, Stefano Fiorucci   +6 more
doaj   +1 more source