Results 51 to 60 of about 42,926,125 (284)

Decreased expression of breast cancer resistance protein in the duodenum in patients with obstructive cholestasis [PDF]

, 2006
Background/Aims: The expression of transporters involved in bile acid homeostasis is differentially regulated during obstructive cholestasis. Since the drug efflux transporter breast cancer resistance protein (BCRP) is known to transport bile acids, we ...
Beuers, Ulrich, Lehmann, Frank, Terracciano, Luigi, Hruz, Petr, Zimmermann, Christian, Gutmann, Heike, Drewe, Juergen, Beglinger, Christoph   +7 more
core   +1 more source

Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance [PDF]

Journal of Medicinal Chemistry, 2017
The role of the G-protein-coupled bile acid receptor TGR5 in various organs, tissues, and cell types, specifically in intestinal endocrine L-cells and brown adipose tissue, has made it a promising therapeutical target in several diseases, especially type-2 diabetes and metabolic syndrome. However, recent studies have shown deleterious on-target effects
Lasalle, Manuel, Hoguet, Vanessa, Hennuyer, Nathalie, Leroux, Florence, Piveteau, Catherine, Belloy, Loic, Lestavel, Sophie, Vallez, Emmanuelle, Dorchies, Emilie, Duplan, Isabelle, Sevin, Emmanuel, Culot, Maxime, Gosselet, Fabien, Boulahjar, Rajâa, Herledan, Adrien, Staels, Bart, Déprez, Benoit, Tailleux, Anne, Charton, Julie   +18 more
openaire   +3 more sources

Farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5) signaling pathways improved the hepatic lipid metabolism in hybrid grouper

Aquaculture Reports, 2022
In the present study, juvenile hybrid grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂) were intraperitoneally injected with taurocholic acid (I-TCA), obeticholic acid (FXR agonist, I-T747), guggulsterone (FXR antagonist, I-TGU), SBI-115 (TGR5 antagonist, I-TSBI), and INT-777 (TGR5 agonist, I-T777), respectively.
Jia Xu, Guilun He, Liutong Chen, Shiwei Xie, Shuyan Chi, Shuang Zhang, Junming Cao, Beiping Tan   +7 more
openaire   +2 more sources

Regulators of G protein signalling proteins in the human myometrium [PDF]

, 2009
The contractile state of the human myometrium is controlled by extracellular signals that promote relaxation or contraction. Many of these signals function through G proteincoupled receptors at the cell surface, stimulating heterotrimeric G proteins and ...
Ladds, Graham, Thornton, Steven, Zervou, Sevasti I., Vatish, Manu, Davey, John   +4 more
core   +1 more source

Regulation of hepatic heme synthesis by drugs, bile acids and nutrition : a transcriptional network regulating [delta]-aminolevulinic acid synthase 1 (ALAS1) [PDF]

, 2008
ALAS1 is the rate limiting enzyme of heme synthesis. It is highly inducible in liver in cases of increased heme demand, such as drug metabolism or in inducible hepatic porphyrias.
Peyer, Anne-Kathrin
core   +1 more source

TGR5 Regulates Macrophage Inflammation in Nonalcoholic Steatohepatitis by Modulating NLRP3 Inflammasome Activation

Frontiers in Immunology, 2021
Nonalcoholic steatohepatitis (NASH) is a chronic liver disease associated with dysregulation of liver metabolism and inflammation. G-protein coupled bile acid receptor 1 (TGR5) is a cell surface receptor that is involved in multiple metabolic pathways ...
Yong Shi, Yong Shi, Yong Shi, Yong Shi, Yong Shi, Wantong Su, Wantong Su, Wantong Su, Wantong Su, Wantong Su, Lei Zhang, Lei Zhang, Lei Zhang, Lei Zhang, Lei Zhang, Chengyu Shi, Chengyu Shi, Chengyu Shi, Chengyu Shi, Chengyu Shi, Jinren Zhou, Jinren Zhou, Jinren Zhou, Jinren Zhou, Jinren Zhou, Peng Wang, Peng Wang, Peng Wang, Peng Wang, Peng Wang, Hao Wang, Hao Wang, Hao Wang, Hao Wang, Hao Wang, Xiaoli Shi, Xiaoli Shi, Xiaoli Shi, Xiaoli Shi, Xiaoli Shi, Song Wei, Song Wei, Song Wei, Song Wei, Song Wei, Qi Wang, Qi Wang, Qi Wang, Qi Wang, Qi Wang, Johan Auwerx, Kristina Schoonjans, Yue Yu, Yue Yu, Yue Yu, Yue Yu, Yue Yu, Rui Pan, Haoming Zhou, Haoming Zhou, Haoming Zhou, Haoming Zhou, Haoming Zhou, Ling Lu, Ling Lu, Ling Lu, Ling Lu, Ling Lu   +67 more
doaj   +1 more source

Overview of Bile Acids Signaling and Perspective on the Signal of Ursodeoxycholic Acid, the Most Hydrophilic Bile Acid, in the Heart

Biomolecules, 2018
Bile acids (BA) are classically known as an important agent in lipid absorption and cholesterol metabolism. Nowadays, their role in glucose regulation and energy homeostasis are widely reported.
Noorul Izzati Hanafi, Anis Syamimi Mohamed, Siti Hamimah Sheikh Abdul Kadir, Mohd Hafiz Dzarfan Othman   +3 more
doaj   +1 more source

Decoding TGR5: A comprehensive review of its impact on cerebral diseases

Pharmacological Research
Currently, unraveling the enigmatic realm of drug targets for cerebral disorders poses a formidable challenge. Takeda G protein-coupled receptor 5 (TGR5), also known as G protein-coupled bile acid receptor 1, is a specific bile acid receptor.
Zehan Zhang, Yifei Zhang, Hongye Peng, Qingqian Yu, Xiangdong Kang, Ying Liu, Yuxiao Zheng, Fafeng Cheng, Xueqian Wang, Feng Li   +9 more
doaj   +1 more source

Bile acid signalling and its role in anxiety disorders

Frontiers in Endocrinology, 2023
Anxiety disorder is a prevalent neuropsychiatric disorder that afflicts 7.3%~28.0% of the world’s population. Bile acids are synthesized by hepatocytes and modulate metabolism via farnesoid X receptor (FXR), G protein-coupled receptor (TGR5), etc.
Simin Chen, Qi Shao, Jiayi Chen, Xinyi Lv, Jing Ji, Yan Liu, Yuehan Song   +6 more
doaj   +1 more source

Role of High total protein in gallbladder bile in the formation of cholesterol gallstones. [PDF]

, 1991
While it is generally accepted that cholesterol supersaturation of bile is of key importance in the rapid formation of cholesterol crystals, the role of total biliary protein and pH in the pathogenesis of cholesterol gallstones is less well understood ...
Ritter, Christoph von, Paumgartner, Gustav, Jüngst, Dieter, Lang, Thomas   +3 more
core   +1 more source