Results 11 to 20 of about 16,618,960 (281)

Structural composition and functional diversities of G proteins in fungi [PDF]

Mycology
Heterotrimeric G proteins (G proteins) are important components of G protein signalling pathways, play an important role in cellular activities, and are composed mainly of three subunits: Gα, Gβ, and Gγ.
Yuanyuan Xia, Lirong Zhu, Haitao Chen, Xiaoli Li, Si Chen, Huan Luo, Jinkui Yang   +6 more
doaj   +2 more sources

Role of G-Proteins and GPCRs in Cardiovascular Pathologies [PDF]

Bioengineering, 2023
Cell signaling is a fundamental process that enables cells to survive under various ecological and environmental contexts and imparts tolerance towards stressful conditions.
Geetika Kaur, Shailendra Kumar Verma, Deepak Singh, Nikhlesh K. Singh   +3 more
doaj   +2 more sources

β-arrestin recruitment facilitates a direct association with G proteins [PDF]

Nature Communications
G protein-coupled receptors (GPCRs) are targets for almost a third of all FDA-approved drugs. GPCRs are known to signal through both heterotrimeric G proteins and β-arrestins. Traditionally these pathways were viewed as largely separable, with G proteins
Claudia Y. Lee, Jeffrey S. Smith, Taylor Kohlmann, Emily M. Meara, Uyen Pham, Frank Kwarcinski, Andrew N. Dates, Jessica K. Orofino, Issac Choi, Ari S. Hilibrand, Chanpreet Jassal, Abigail Gilmer, Stephen C. Blacklow, Gregory G. Tall, Andrew C. Kruse, Sudarshan Rajagopal   +15 more
doaj   +2 more sources

Regulation of DNA damage response by trimeric G-proteins [PDF]

iScience, 2023
Summary: Upon sensing DNA double-strand breaks (DSBs), eukaryotic cells either die or repair DSBs via one of the two competing pathways, i.e., non-homologous end-joining (NHEJ) or homologous recombination (HR). We show that cell fate after DSBs hinges on
Amer Ali Abd El-Hafeez, Nina Sun, Anirban Chakraborty, Jason Ear, Suchismita Roy, Pranavi Chamarthi, Navin Rajapakse, Soumita Das, Kathryn E. Luker, Tapas K. Hazra, Gary D. Luker, Pradipta Ghosh   +11 more
doaj   +2 more sources

Expression and Purification of Mini G Proteins from Escherichia coli

Bio-Protocol, 2017
Heterotrimeric G proteins modulate intracellular signalling by transducing information from cell surface G protein-coupled receptors (GPCRs) to cytoplasmic effector proteins.
Byron Carpenter, Christopher Tate
doaj   +2 more sources

Visualization of endogenous G proteins on endosomes and other organelles [PDF]

eLife
Classical G-protein-coupled receptor (GPCR) signaling takes place in response to extracellular stimuli and involves receptors and heterotrimeric G proteins located at the plasma membrane. It has recently been established that GPCR signaling can also take
Wonjo Jang, Kanishka Senarath, Gavin Feinberg, Sumin Lu, Nevin A Lambert   +4 more
doaj   +2 more sources

Direct crosstalk between GPCRs and ion channels via G proteins [PDF]

Experimental and Molecular Medicine
In recent years, cryo-electron microscopy structures of ion channels in complex with G proteins have been resolved, providing insights into the molecular mechanisms underlying the crosstalk between G protein-coupled receptors (GPCRs) and ion channels ...
Sun-Hong Kim, Jinhyeong Kim, Insuk So, Hyung Ho Lee   +3 more
doaj   +2 more sources

An Insight into GPCR and G-Proteins as Cancer Drivers [PDF]

Cells, 2021
G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling receptors known to play a crucial role in various physiological functions, including tumor growth and metastasis.
Preeti Kumari Chaudhary, Soochong Kim
doaj   +2 more sources

G-protein interaction with TPR-containing proteins.

, 2004
G-protein interaction with TPR-containing ...
Caroline. Marty (7970141)
core   +5 more sources

G-Proteins in N.I.D.D.M. and Hypertension [PDF]

, 1991
G-proteins are guanine-nucleotide-binding regulatory proteins which couple receptors to effector mechanisms; G-protein associated 'second messengers' include cAMP and the phospho-inositides, while other G-proteins are coupled to calcium and potassium ...
McLellan, Alastair Robert
core   +5 more sources