Results 1 to 10 of about 75,987 (290)
Identification of a novel protein complex containing ASIC1a and GABAA receptors and their interregulation. [PDF]
PLoS ONE, 2014 Acid-sensing ion channels (ASICs) belong to the family of the epithelial sodium channel/degenerin (ENaC/DEG) and are activated by extracellular protons. They are widely distributed within both the central and peripheral nervous systems.
Dongbo Zhao +6 more
doaj +3 more sources
Post-synaptic GABAA receptors potentiate transmission by recruiting CaV2 channels to their inputs [PDF]
Cell Reports, 2023 Summary: We describe a retrograde synaptic signal at the C. elegans GABAergic neuromuscular junction. At this synapse, GABA release is controlled by two voltage-activated calcium channels (UNC-2/CaV2 and EGL-19/CaV1), and muscle responses are mediated by
Jian Zhao +3 more
doaj +2 more sources
Journal of Pharmacological Sciences, 2007 We investigated the involvement of γ-aminobutyric acidA (GABAA) receptors in the neuroprotective effect of γ-glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice.
Nobuaki Egashira +6 more
doaj +3 more sources
Cyclin D1-Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors. [PDF]
Cell Mol Life Sci, 2023 Pedraza N +12 more
europepmc +3 more sources
Cell & Bioscience, 2022 Background Genetic variants in the subunits of the gamma-aminobutyric acid type A (GABAA) receptors are implicated in the onset of multiple pathologic conditions including genetic epilepsy.
Meng Wang +9 more
doaj +1 more source
Lack of Neurosteroid Selectivity at δ vs. γ2-Containing GABAA Receptors in Dentate Granule Neurons
Frontiers in Molecular Neuroscience, 2020 GABAA receptors mediate a large fraction of inhibitory neurotransmission in the central nervous system. Two major classes of GABAA receptors are γ2-containing receptors and δ-containing receptors, which are largely located synaptically and ...
Xinguo Lu +6 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Zulresso (brexanolone) is an aqueous formulation of the neurosteroid, allopregnanolone, and the only FDA-approved medication for the treatment of postpartum depression (PPD).
Alexander B. Horwitz +2 more
doaj +1 more source
Expression of the eight GABAA receptor α subunits in the developing zebrafish central nervous system. [PDF]
PLoS ONE, 2018 GABA is a robust regulator of both developing and mature neural networks. It exerts many of its effects through GABAA receptors, which are heteropentamers assembled from a large array of subunits encoded by distinct genes.
Bryan Monesson-Olson +6 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2022 Background: Perioperative neurocognitive disorders (PNDs) occur commonly in older patients after anesthesia and surgery. Treating astrocytes with general anesthetic drugs stimulates the release of soluble factors that increase the cell-surface expression
Woosuk Chung +7 more
doaj +1 more source
eLife, 2018 Fast inhibitory neurotransmission in the mammalian nervous system is largely mediated by GABAA receptors, chloride-selective members of the superfamily of pentameric Cys-loop receptors.
Swastik Phulera +6 more
doaj +1 more source