Results 21 to 30 of about 75,987 (290)

Photo-antagonism of the GABAA receptor [PDF]

, 2014
Neurotransmitter receptor trafficking is fundamentally important for synaptic transmission and neural network activity. GABAA receptors and inhibitory synapses are vital components of brain function, yet much of our knowledge regarding receptor mobility ...
A Sali, A Triller, B Frolund, C Notredame, CG Wermuth, CL Padgett, CM Houston, D Belelli, DA Wagner, DM Kullmann, E Sigel, EF Pettersen, EG Steward, EM Schneider Gasser, EO Mann, F Iqbal, G Jones, G Nyiri, H Kiefer, H Mohler, H Zhong, J Amin, J Isaacson, JG Newell, JG Newell, JH Holden, JJ Chambers, JM Fritschy, JQ Kang, JT Kittler, K Ramamoorthi, L Dubinsky, LB Kier, M Ernst, M Heaulme, M Mortensen, M Mortensen, M Mortensen, M Mortensen, MA Simmonds, MC Ashby, N Zacharias, NG Bowery, O Arunlakshana, P Thomas, PS Miller, R Sathyapriya, RW Olsen, S Ueno, SB Hansen, SC Lummis, SE Westh-Hansen, SE Westh-Hansen, SJ Moss, T Klausberger, T Klausberger, TC Turek, U Resch-Genger, Y Bogdanov, Y Chang   +59 more
core   +1 more source

GABA potency at GABAA receptors found in synaptic and extrasynaptic zones

Frontiers in Cellular Neuroscience, 2012
The potency of GABA is vitally important for its primary role in activating GABAA receptors and acting as an inhibitory neurotransmitter. Although numerous laboratories have presented information, directly or indirectly, on GABA potency, it is often ...
Martin eMortensen, Bijal ePatel, Trevor G. Smart   +2 more
doaj   +1 more source

Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a lugaro cell to Purkinje cell synapse [PDF]

, 2003
We recorded a novel fast GABAergic synaptic current in cerebellar Purkinje cells in rat brain slices using patch-clamp techniques. Because of a relatively low sensitivity to bicuculline, these currents can be recorded under conditions in which basket ...
Dean, I., Edwards, F.A., Robertson, S.J.
core   +3 more sources

Extrasynaptic α6 subunit-containing GABAA receptors modulate excitability in turtle spinal motoneurons.

PLoS ONE, 2014
Motoneurons are furnished with a vast repertoire of ionotropic and metabotropic receptors as well as ion channels responsible for maintaining the resting membrane potential and involved in the regulation of the mechanisms underlying its membrane ...
Carmen Andres, Justo Aguilar, Ricardo González-Ramírez, David Elias-Viñas, Ricardo Felix, Rodolfo Delgado-Lezama   +5 more
doaj   +1 more source

Characterization of zebrafish GABAA receptor subunits

Scientific Reports, 2021
γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system, exerts its effect through the activation of GABA receptors. GABAA receptors are ligand-gated chloride channels composed of five subunit proteins.
Kenichiro Sadamitsu, Leona Shigemitsu, Marina Suzuki, Daishi Ito, Makoto Kashima, Hiromi Hirata   +5 more
doaj   +1 more source

Interaction of hypothalamic GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors controlling heart rate in rats [PDF]

, 1991
We have previously shown that microinjection of drugs that impair gamma-aminobutyric acid (GABA)-mediated synaptic inhibition into the dorsomedial hypothalamus (DMH) of rats generates cardiovascular and behavioral changes that mimic the response to ...
DiMicco, Joseph A., Soltis, Robert P.
core   +2 more sources

Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons [PDF]

, 2020
OBJECTIVE: Neurosteroids regulate neuronal excitability by potentiating γ-aminobutyric acid type-A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is ...
Jansen, Laura A, Joshi, Suchitra, Kapur, Jaideep, Roden, William H   +3 more
core   +2 more sources

Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons.

PLoS ONE, 2014
GABAA receptors distributed in somatodendritic compartments play critical roles in regulating neuronal activities, including spike timing and firing pattern; however, the properties and functions of GABAA receptors at the axon are still poorly understood.
Yang Xia, Yuan Zhao, Mingpo Yang, Shaoqun Zeng, Yousheng Shu   +4 more
doaj   +1 more source

Neuronal Gamma-Aminobutyric Acid (GABA) Type A Receptors Undergo Cognate Ligand Chaperoning in the Endoplasmic Reticulum by Endogenous GABA

Frontiers in Cellular Neuroscience, 2015
GABAA receptors mediate fast inhibitory neurotransmission in the brain. Dysfunction of these receptors is associated with various psychiatric/neurological disorders and drugs targeting this receptor are widely used therapeutic agents.
Ping eWang, Randa S Eshaq, Charlie K. Meshul, Charlie K. Meshul, Cynthia eMoore, Cynthia eMoore, Rebecca L. Hood, Rebecca L. Hood, Nancy Jo Leidenheimer   +8 more
doaj   +1 more source

Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes

Scientific Reports, 2017
Aminoquinoline derivatives were evaluated against a panel of receptors/channels/transporters in radioligand binding experiments. One of these derivatives (DCUK-OEt) displayed micromolar affinity for brain γ-aminobutyric acid type A (GABAA) receptors ...
Cecilia M. Borghese, Melissa Herman, Lawrence D. Snell, Keri J. Lawrence, Hyun-Young Lee, Donald S. Backos, Lauren A. Vanderlinden, R. Adron Harris, Marisa Roberto, Paula L. Hoffman, Boris Tabakoff   +10 more
doaj   +1 more source