Results 21 to 30 of about 44,091 (186)

Tri-partite complex for axonal transport drug delivery achieves pharmacological effect. [PDF]

, 2010
BACKGROUND: Targeted delivery of pharmaceutical agents into selected populations of CNS (Central Nervous System) neurons is an extremely compelling goal.
Sokoloff Alan J, Miri D Rabinowitz, Munglani, Raj, Filler, Aaron G, Filler, A.G, Munglani, R, Chris Abell, Rabinowitz, Miri D, Terrence W Deacon, Andrew ML Lever, Deacon Terrence W, Munglani Raj, Mark Bacon, Sokoloff, Alan J, Franklyn A Howe, Deacon, T.W, Whiteside, Garth T, Bacon, Mark, Howe, F.A, Abell, Chris, Sokoloff, AJ, Griffiths, J.R, Filler Aaron G, Lever, Andrew ML, Howe, FA, Alan J Sokoloff, Martyn Frederickson, Bell B Anthony, Bell, B.A, Bacon, M, Frederickson Martyn, Garth T Whiteside, Griffiths, John R, Abell, C, Aaron G Filler, B Anthony Bell, Griffiths John R, Rabinowitz Miri D, Bacon Mark, Bell, B Anthony, Lever, A.M.L, Frederickson, Martyn, Filler, AG, Abell Chris, Sokoloff, A.J, Frederickson, M, John R Griffiths, Lever Andrew ML, Whiteside Garth T, Deacon, Terrence W, Bell, BA, Whiteside, GT, Griffiths, JR, Rabinowitz, MD, Deacon, TW, Lever, AM, Whiteside, G.T, Howe Franklyn A, Howe, Franklyn A, Raj Munglani, Rabinowitz, M.D   +60 more
core   +3 more sources

Pharmacokinetics and pharmacodynamics of repeat dosing of gabapentin in adult horses

Journal of Veterinary Internal Medicine, 2022
Background The repeated administration of high doses of gabapentin may provide better analgesia in horses than current clinical protocols. Hypothesis and Objectives Administration of gabapentin at 40 and 120 mg/kg PO q 12 h for 14 days will not alter ...
Jenifer R. Gold, Tamara L. Grubb, Sherry Cox, Lais Malavasi, Nicholas L. Villarino   +4 more
doaj   +1 more source

The effects of gabapentin pretreatment on brain injury induced by focal cerebral ischemia/reperfusion in the rat [PDF]

Korean Journal of Anesthesiology, 2010
BackgroundExperimental studies have shown that gabapentin can reduce neuronal injury in the setting of cerebral ischemia, but the mechanisms have not yet been clearly determined.
Yoo-kyung Kim, Jeong-Gill Leem, Ji-Yeon Sim, Sung-moon Jeong, Kyoung-Woon Joung   +4 more
doaj   +1 more source

Effects of pregabalin and gabapentin on postoperative pain and opioid consumption after laparoscopic cholecystectomy [PDF]

Korean Journal of Anesthesiology, 2017
BackgroundGabapentin and pregabalin are antiepileptic drugs that are also used for chronic pain treatment. This study evaluated the effects of pregabalin and gabapentin on postoperative pain in patients undergoing laparoscopic cholecystectomy.MethodsA ...
Mohammad Eidy, Mohammad Reza Fazel, Hossein Abdolrahimzadeh, Ali Reza Moravveji, Ebrahim Kochaki, Mahdi Mohammadzadeh   +5 more
doaj   +1 more source

Protective Effect of Gabapentin on N-methyl-D-aspartate–Induced Excitotoxicity in Rat Hippocampal CA1 Neurons

Journal of Pharmacological Sciences, 2009
Gabapentin was developed as an anticonvulsant, but has also been used to alleviate hyperalgesia in neuropathic pain. In this study, the protective effect of gabapentin against N-methyl-D-aspartate (NMDA)-induced excitotoxicity in rat hippocampal CA1 ...
Young-Sick Kim, Hyun-Kyung Chang, Jin-Woo Lee, Yun-Hee Sung, Sung-Eun Kim, Mal-Soon Shin, Jae-Woo Yi, Je-Hoon Park, Hong Kim, Chang-Ju Kim   +9 more
doaj   +1 more source

Anticonvulsants in the treatment of aggression in the demented elderly : an update [PDF]

, 2009
Introduction Complex psychopathological and behavioral symptoms, such as delusions and aggression against care providers, are often the primary cause of acute hospital admissions of elderly patients to emergency units and psychiatric departments.
Ana Gonzalez-Pinto, Francesc Colom, Hampel, Harald, Colom, Francesc, 1971-, Johannes Pantel, Heinz Grunze, Amann, Benedikt L., Naber, Dieter, Gonzalez-Pinto, Ana, Pantel, Johannes, Eduard Vieta, Colom, Francesc, Vieta, Eduard, Harald Hampel, Amann, Benedikt, Dieter Naber, Grunze, Heinz, Vieta i Pascual, Eduard, 1963-, Benedikt Amann   +18 more
core   +1 more source

Comparative Effectiveness and Safety of Original Gabapentin and Generic Gabapentin in Treating Patients with Neuropathic Pain at Siriraj Hospital, Bangkok, Thailand

Siriraj Medical Journal, 2020
Background: Neuropathic pain (NP) develops as a consequence of a lesion or disease affecting the somatosensory system. Patients with severe NP usually suffer from pain and may need many treatment options.
Rungsan Chaisewikul, Ratikorn Saejong, Sasima Tongsai, Visanu Thamlikitkul   +3 more
doaj  

Gabapentin for Postoperative Vomiting in Children Requiring Posterior Fossa Tumor Resection

, 2017
Gabapentin is well known for its pain control and antiepileptic effect, but its antiemetic effect is poorly investigated. Here we report on effective gabapentin use for refractory vomiting after craniotomy in two children with medulloblastoma in the ...
Tsai, Ko-Chun;Yang, Yung-Li;Fan, Pi-Chuan, 范碧娟;楊永立   +1 more
core   +1 more source

Gabapentin adjunctive to risperidone or olanzapine in partially responsive schizophrenia: an open-label pilot study [PDF]

, 2010
Adel GabrielDepartments of Psychiatry and Community Health Sciences, University of Calgary, Alberta, CanadaBackground: There is a great need in the treatment of schizophrenia for a drug, or drug ­combinations, to improve clinical response with ...
Adel Gabriel, Gabriel, Adel A.R.
core   +1 more source

Gabapentin prevalence: clinical and forensic experience in St. Louis, Missouri, USA

Forensic Sciences Research, 2021
Gabapentin (Neurontin) is an anti-epileptic drug that has had wide off-label prescription use since market release due to presumed negligible abuse potential.
Sarah B. Riley, Kelsie Garbutt, Chelsea Crow, T. Scott Isbell, Anthony J. Scalzo   +4 more
doaj   +1 more source