Results 31 to 40 of about 47,104 (255)

Protective Effect of Gabapentin on N-methyl-D-aspartate–Induced Excitotoxicity in Rat Hippocampal CA1 Neurons

Journal of Pharmacological Sciences, 2009
Gabapentin was developed as an anticonvulsant, but has also been used to alleviate hyperalgesia in neuropathic pain. In this study, the protective effect of gabapentin against N-methyl-D-aspartate (NMDA)-induced excitotoxicity in rat hippocampal CA1 ...
Young-Sick Kim, Hyun-Kyung Chang, Jin-Woo Lee, Yun-Hee Sung, Sung-Eun Kim, Mal-Soon Shin, Jae-Woo Yi, Je-Hoon Park, Hong Kim, Chang-Ju Kim   +9 more
doaj   +1 more source

Gabapentin adjunctive to risperidone or olanzapine in partially responsive schizophrenia: an open-label pilot study [PDF]

, 2010
Adel GabrielDepartments of Psychiatry and Community Health Sciences, University of Calgary, Alberta, CanadaBackground: There is a great need in the treatment of schizophrenia for a drug, or drug ­combinations, to improve clinical response with ...
Adel Gabriel, Gabriel, Adel A.R.
core   +1 more source

Effects of pregabalin and gabapentin on postoperative pain and opioid consumption after laparoscopic cholecystectomy [PDF]

Korean Journal of Anesthesiology, 2017
BackgroundGabapentin and pregabalin are antiepileptic drugs that are also used for chronic pain treatment. This study evaluated the effects of pregabalin and gabapentin on postoperative pain in patients undergoing laparoscopic cholecystectomy.MethodsA ...
Mohammad Eidy, Mohammad Reza Fazel, Hossein Abdolrahimzadeh, Ali Reza Moravveji, Ebrahim Kochaki, Mahdi Mohammadzadeh   +5 more
doaj   +1 more source

Gabapentin for Postoperative Vomiting in Children Requiring Posterior Fossa Tumor Resection

, 2017
Gabapentin is well known for its pain control and antiepileptic effect, but its antiemetic effect is poorly investigated. Here we report on effective gabapentin use for refractory vomiting after craniotomy in two children with medulloblastoma in the ...
Tsai, Ko-Chun;Yang, Yung-Li;Fan, Pi-Chuan, 范碧娟;楊永立   +1 more
core   +1 more source

Gabapentin prevalence: clinical and forensic experience in St. Louis, Missouri, USA

Forensic Sciences Research, 2021
Gabapentin (Neurontin) is an anti-epileptic drug that has had wide off-label prescription use since market release due to presumed negligible abuse potential.
Sarah B. Riley, Kelsie Garbutt, Chelsea Crow, T. Scott Isbell, Anthony J. Scalzo   +4 more
doaj   +1 more source

More Drug Monitoring and Less CT Scans of the Brain: Gabapentin Overdose in Two Peritoneal Dialysis Patients

Case Reports in Nephrology and Dialysis, 2022
In parallel with the decline of renal excretory function, drug dosing of many drugs becomes more challenging. Finding the right dose is even more difficult if kidney replacement therapy is instituted.
Kijanosh Lehmann, Sara Diab, Torsten M. Meyer, Jan T. Kielstein, Gabriele Eden   +4 more
doaj   +1 more source

EFEK ANTINOCICEPTIF GABA AGONIS GABAPENTIN TERHADAP NYERI NEUROPATI PADA HEWAN COBA MENCIT [PDF]

, 2008
Penelitian terhadap efek antinociceptif GABA agonis gabapentin terhadap nyeri neuropati telah dilakukan dengan inenggunakan hewan coba mencit. Gabapentin merupakan senyawa yang analog dengan GABA dan berperan dalam meningkatkan konsentrasi dan sintesis ...
Budi Suprapti, Dra., M.Si, Suharjono, Dr., MS., Apt, Bambang Subakti Z, SSi., MClin., Pharm., Apt   +2 more
core   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Tri-partite complex for axonal transport drug delivery achieves pharmacological effect. [PDF]

, 2010
BACKGROUND: Targeted delivery of pharmaceutical agents into selected populations of CNS (Central Nervous System) neurons is an extremely compelling goal.
Sokoloff Alan J, Miri D Rabinowitz, Munglani, Raj, Filler, Aaron G, Filler, A.G, Munglani, R, Chris Abell, Rabinowitz, Miri D, Terrence W Deacon, Andrew ML Lever, Deacon Terrence W, Munglani Raj, Mark Bacon, Sokoloff, Alan J, Franklyn A Howe, Deacon, T.W, Whiteside, Garth T, Bacon, Mark, Howe, F.A, Abell, Chris, Sokoloff, AJ, Griffiths, J.R, Filler Aaron G, Lever, Andrew ML, Howe, FA, Alan J Sokoloff, Martyn Frederickson, Bell B Anthony, Bell, B.A, Bacon, M, Frederickson Martyn, Garth T Whiteside, Griffiths, John R, Abell, C, Aaron G Filler, B Anthony Bell, Griffiths John R, Rabinowitz Miri D, Bacon Mark, Bell, B Anthony, Lever, A.M.L, Frederickson, Martyn, Filler, AG, Abell Chris, Sokoloff, A.J, Frederickson, M, John R Griffiths, Lever Andrew ML, Whiteside Garth T, Deacon, Terrence W, Bell, BA, Whiteside, GT, Griffiths, JR, Rabinowitz, MD, Deacon, TW, Lever, AM, Whiteside, G.T, Howe Franklyn A, Howe, Franklyn A, Raj Munglani, Rabinowitz, M.D   +60 more
core   +3 more sources

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source