Results 51 to 60 of about 47,104 (255)

Obstructive Sleep Apnea in Children With Lennox‐Gastaut Syndrome: A Case Series

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Background Lennox–Gastaut syndrome (LGS) is a highly refractory epilepsy syndrome associated with poor sleep. Abnormal sleep can lower seizure threshold, yet a treatable cause of disordered sleep, obstructive sleep apnea (OSA), is understudied in children with LGS.
Gita Gupta, Louise M. O'Brien, Fauziya Hassan, Stephanie M. D. Rau, Arushi Gupta, Renée A Shellhaas   +5 more
wiley   +1 more source

Gabapentin Monotherapy for Refractory Seizures

, 1997
The results of an 8-day, controlled, multicenter study of gabapentin monotherapy in 82 hospitalized patients with refractory complex partial or secondarily generalized seizures are reported by members of the US Gabapentin Study ...
J Gordon Millichap, Millichap, J. Gordon
core   +1 more source

Population‐Stratified Distributions of Post‐Mortem Blood Drug Concentrations: An Epidemiological Framework for Contextual Interpretation

Drug Testing and Analysis, EarlyView.
Post‐mortem blood drug concentrations exhibit substantial overlap between deaths in which a drug was implicated and those in which it was not. Analysis of over 58,000 NPSUM cases demonstrates that demographic stratification does not resolve this uncertainty, reinforcing the need for contextual, evidence‐based interpretation rather than concentration ...
Thikra Algahtani, Kirsten L. Rock, Kathleen Rice‐Davies, Rebecca Lo, Benedict Morley, Stephen Morley, Caroline S. Copeland   +6 more
wiley   +1 more source

Gabapentin enacarbil – clinical efficacy in restless legs syndrome

Neuropsychiatric Disease and Treatment, 2010
Pinky Agarwal1, Alida Griffith1, Henry R Costantino2, Narendra Vaish31Booth Gardner Parkinson’s Center, Kirkland, WA, USA; 2Costantino Consulting, Woodinville, WA, USA; 3Kirkland, WA, USAAbstract: Restless legs syndrome (RLS) is a sleep-related
Pinky Agarwal, Alida Griffith, Henry R Costantino, et al   +3 more
doaj  

Neuropeptide FF (FLFQPQRF-NH2) and its Fragments Bind to α2δ Subunit of Voltage-Gated Calcium Channels

Journal of Pharmacy & Pharmaceutical Sciences, 2019
Purpose: Gabapentin, a drug for neuropathic pain, exerts its therapeutic effect via inhibition of the a2d subunit of N-type Ca2+ channels. Thus, finding peptides that specifically displace gabapentin from its binding site may lead to the development of ...
Hanna Skubatz
doaj   +1 more source

NMDAR‐antibody encephalitis: Seizure semiology and EEG findings

Epileptic Disorders, EarlyView.
Abstract Background N‐methyl‐D‐aspartate receptor antibody encephalitis (NMDAR‐Ab‐E) is an autoantibody‐mediated disorder, characterized by acute development of neuropsychiatric symptoms, seizures, movement disorders, and autonomic instability. Objectives To describe acute seizure semiology and electroencephalogram (EEG) findings in patients with a ...
Maria Emilia C. Andraus, Bernard Liem, Sidra Aurangzeb, Mkael Symmonds, Adam E. Handel, Sarosh R. Irani, Arjune Sen   +6 more
wiley   +1 more source

The effectiveness of adding on or switching antiseizure medications after the first fails to control focal epilepsy: A systematic review of randomized controlled trials

Epileptic Disorders, EarlyView.
Abstract Focal epilepsy constitutes 60–70% of epilepsy, and up to half of patients do not achieve seizure freedom with their first antiseizure medication (ASM). When the first ASM fails, evidence guiding whether to switch or add‐on another ASM and which ASMs to use is limited. This review synthesized evidence from randomized controlled trials (RCTs) on
Isaac J. Egesa, Gashirai Mbizvo, Michelle Maden, Thomas Spain, Richard Emsley, Laura J. Bonnett, Anthony G. Marson, Catrin Tudur Smith   +7 more
wiley   +1 more source

Gabapentin Toxicity in Patients with Chronic Kidney Disease; Series of Our Cases

Turkish Journal of Nephrology, 2019
Gabapentin is an anticonvulsant with analgesic and anxiolytic effects and also an agent used for treatment of a variety of chronic neuropathic pains. Because gabapentin is eliminated solely through the kidney, kidney failure poses a risk for gabapentin ...
Ali KARAGÖZ, İbrahim GÜNEY, Raziye YAZICI, Şevket ARSLAN, Lütfullah ALTINTEPE   +4 more
doaj  

Perioperative gabapentin and pregabalin in cardiac surgery: a systematic review and meta-analysis

Revista Brasileira de Anestesiologia
Objectives: Sternotomy for cardiac surgeries causes significant postoperative pain and when not properly managed may cause significant morbidity. As neuropathic pain is a significant component here, gabapentin and pregabalin may be effective in these ...
Souvik Maitra, Dalim K. Baidya, Sulagna Bhattacharjee, Anirban Som   +3 more
doaj   +1 more source

Enhancing quality of mental health service for veterans with seizures

Epilepsia, EarlyView.
Abstract Psychiatric disorders are commonly identified in people with seizures (PWS). Comorbid mood, anxiety, and trauma‐ and stressor‐related disorders are highly prevalent and not consistently recognized or treated promptly. Veterans with seizures are particularly vulnerable to neuropsychiatric comorbidities, including a higher prevalence of ...
Maria Raquel Lopez, W. Curt LaFrance Jr., Kristen Mordecai, Anna E. Blanken, Mary Jo Pugh, Krista Ocier, Hamada Altalib   +6 more
wiley   +1 more source