Results 41 to 50 of about 34,902 (147)

THE EFFECT OF GABAPENTIN ON ACETIC ACID INDUCED VISCERAL PAIN: INVOLVMENT OF MU OPIOID & GABAa RECEPTORS

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2007
BACKGROUND AND OBJECTIVES: Gabapentin is an anticonvulsant drug which also possesses antinociceptive effect in wide spectrum kind of pain, like neuropathic pain. However its effectiveness on visceral pain is not elucidated yet.
M Meimandi, GH.R Sepehri,, M Mobasher, A Parhizgar   +3 more
doaj  

Comparison Effect of Pre-Emptive Gabapentin and Oxycodone on Pain After Abdominal Hysterectomy: A Double Blind Randomized Clinical Trial

Acta Medica Iranica, 2018
Gabapentin is popular analgesic adjuvants for improving postoperative pain management. The aim of this study was to compare the preventive effects of pre-emptive oxycodone and gabapentin on acute pain after elective abdominal hysterectomy.
Valiollah Hassani, Behrooz Zaman, Mehrzad Alimian, Reza Safaeian, Abolfazl Mehdizadehkashi, Shohreh Karami, Davood Ommi   +6 more
doaj  

Association of perioperative initiation of gabapentin versus pregabalin with kidney function: a target trial emulation study

Frontiers in Medicine
BackgroundGabapentinoids, such as gabapentin and pregabalin, are opioid substitutes commonly included in perioperative multimodal analgesia regimens. We investigated whether the initiation of gabapentin and pregabalin during the perioperative period have
Yanfang He, Liqian Mo, Juan Li, Dongying Lu, Jinlei Niu, Ying Li, Qiying Zeng, Yueming Gao   +7 more
doaj   +1 more source

Efficacy of gabapentin for the prevention of postherpetic neuralgia in patients with acute herpes zoster: A double blind, randomized controlled trial.

PLoS ONE, 2019
BackgroundPostherpetic neuralgia (PHN) is the most common complication of herpes zoster (HZ). Previous trials have reported that gabapentin can relieve chronic neuropathic pain, but its effect on prevention of PHN is unclear.ObjectiveTo assess the ...
Oana Bulilete, Alfonso Leiva, Manuel Rullán, Antonia Roca, Joan Llobera, PHN Group   +5 more
doaj   +1 more source

The use of gabapentin enacarbil in the treatment of restless legs syndrome

Therapeutic Advances in Neurological Disorders, 2010
Restless legs syndrome (RLS) is a common sleep-related neurological disorder that is characterized by the urge to move, worsening at rest, improvement with activity, and worsening in the evening and night.
Toby C. Yaltho, William G. Ondo
doaj   +1 more source

Myoclonus in renal failure: Two cases of gabapentin toxicity

Epilepsy and Behavior Case Reports, 2014
Gabapentin, an AED approved for the adjunctive treatment of partial seizures with/without secondary generalization and for the treatment of postherpetic neuralgia, is frequently used off-label for the treatment of both psychiatric and pain disorders ...
Kenneth R. Kaufman, Amay Parikh, Lili Chan, Mary Bridgeman, Milisha Shah   +4 more
doaj   +1 more source

Gabapentin in pregnancy and the risk of adverse neonatal and maternal outcomes: A population-based cohort study nested in the US Medicaid Analytic eXtract dataset.

PLoS Medicine, 2020
BackgroundDespite the widespread use, only sparse information is available on the safety of gabapentin during pregnancy. We sought to evaluate the association between gabapentin exposure during pregnancy and risk of adverse neonatal and maternal outcomes.
Elisabetta Patorno, Sonia Hernandez-Diaz, Krista F Huybrechts, Rishi J Desai, Jacqueline M Cohen, Helen Mogun, Brian T Bateman   +6 more
doaj   +1 more source

Development and Evaluation of Topical Gabapentin Formulations

Pharmaceutics, 2017
Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed ...
Christopher J. Martin, Natalie Alcock, Sarah Hiom, James C. Birchall   +3 more
doaj   +1 more source

Protein Kinase A–Dependence of the Supraspinally Mediated Analgesic Effects of Gabapentin on Thermal and Mechanical Hypersensitivity

Journal of Pharmacological Sciences, 2009
.: We have recently shown that gabapentin generates protein kinase A (PKA)-dependent presynaptic inhibition of GABAergic synaptic transmission in locus coeruleus (LC) neurons only under neuropathic states.
Keiko Takasu, Yu Kinoshita, Hideki Ono, Mitsuo Tanabe   +3 more
doaj   +1 more source

Gabapentin Inhibits Protein Kinase C Epsilon Translocation in Cultured Sensory Neurons with Additive Effects When Coapplied with Paracetamol (Acetaminophen)

The Scientific World Journal, 2017
Gabapentin is a well-established anticonvulsant drug which is also effective for the treatment of neuropathic pain. Although the exact mechanism leading to relief of allodynia and hyperalgesia caused by neuropathy is not known, the blocking effect of ...
Vittorio Vellani, Chiara Giacomoni
doaj   +1 more source