Results 91 to 100 of about 17,093 (242)

Alpha-Galactosylceramide/CD1d-Antibody Fusion Proteins Redirect Invariant Natural Killer T Cell Immunity to Solid Tumors and Promote Prolonged Therapeutic Responses. [PDF]

, 2017
Major progress in cancer immunotherapies have been obtained by the use of tumor targeting strategies, in particular with the development of bi-functional fusion proteins such as ImmTacs or BiTes, which engage effector T cells for targeted elimination of ...
Donda, A., Zhang, L.
core   +1 more source

Synergistic induction of adaptive antitumor immunity by codelivery of antigen with α-galactosylceramide on exosomes.

Cancer Research, 2013
Exosomes and the invariant NKT (iNKT) immune cell ligand α-galactosylceramide (αGC) may offer novel tools for cancer immunotherapy. In this study, we investigated whether exosomes loaded with αGC can activate iNKT cells and potentiate a cancer-specific ...
U. Gehrmann, S. Hiltbrunner, Anna-Maria Georgoudaki, M. Karlsson, T. Näslund, S. Gabrielsson   +5 more
semanticscholar   +1 more source

Extracellular vesicle‐based vaccines and immunotherapeutics for treatment of cancer

Interdisciplinary Medicine, Volume 4, Issue 1, January 2026.
This review highlights the innovative value of extracellular vesicles (EVs) as cancer vaccines and immunotherapy carriers. EVs have natural advantages such as low immunogenicity, high biocompatibility, stability, and precise targeting, enabling efficient delivery of tumor antigens (e.g., HER2, AFP) and immune stimulants (e.g., TLR ligands, cytokines ...
Lejia Tan, Haonan Xing, Fang Fang, Yuanyu Huang, Mei Lu   +4 more
wiley   +1 more source

Reduced plasma hexosylceramides in frontotemporal dementia are a biomarker of white matter integrity

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Blood biomarkers are needed to facilitate new therapeutic trials and improve management of behavioral variant frontotemporal dementia (bvFTD).
Oana C. Marian, Sophie Matis, Carol Dobson‐Stone, Woojin S. Kim, John B. Kwok, Olivier Piguet, Glenda M. Halliday, Ramon Landin‐Romero, Anthony S. Don   +8 more
doaj   +1 more source

Exosomes: Versatile Nano Mediators of Immune Regulation. [PDF]

, 2019
One of many types of extracellular vesicles (EVs), exosomes are nanovesicle structures that are released by almost all living cells that can perform a wide range of critical biological functions.
Cacalano, Nicholas A, Huyan, Ting, Li, Qi, Peng, Hourong, Wang, Helei   +4 more
core   +1 more source

The nanoparticulation by octaarginine-modified liposome improves α-galactosylceramide-mediated antitumor therapy via systemic administration.

Journal of Controlled Release, 2013
Alpha-galactosylceramide (αGC), a lipid antigen present on CD1d molecules, is predicted to have clinical applications as a new class of adjuvant, because αGC strongly activates natural killer T (NKT) cells which produce large amounts of IFN-γ.
Takashi Nakamura, Daiki Yamazaki, J. Yamauchi, H. Harashima   +3 more
semanticscholar   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, Volume 36, Issue 1, January 2026.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Differential tumor surveillance by natural killer (NK) and NKT cells [PDF]

, 2000
Natural tumor surveillance capabilities of the host were investigated in six different mouse tumor models where endogenous interleukin (IL)-12. does or does not dictate the efficiency of the innate immune response.
Arase, Arase, Arase, Bendelac, Bendelac, Brunda, Burdin, Carnaud, Cui, Dale I. Godfrey, Dao, Eberl, Erika Cretney, Fernandez, Hammond, Hashimoto, Joseph A. Trapani, Kagi, Kaplan, Karlhofer, Karre, Kawamura, Kawano, Kawano, Kevin Y. T. Thia, Kitamura, Kobayashi, Kodama, Koyasu, Koyasu, Lantz, Lynch, MacDonald, Magram, Mark J. Smyth, Masaru Taniguchi, Nadine Y. Crowe, Noguchi, Ohteki, Ryan, Salazar-Mather, Schofield, Shayna E.A. Street, Smyth, Smyth, Sonja B. Pelikan, Sugie, Svane, Takahashi, Talmadge, Taniguchi, Tetsu Kawano, Trinchieri, van den Broek, Yoshimoto, Zlotnik   +55 more
core   +2 more sources

Sex in Immune Cells and Parasitic Diseases — A Complex Relationship

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Epidemiological studies consistently show that many parasitic diseases affect males more frequently than females. These disparities are multifactorial, arising partly from gender‐specific behaviors that influence exposure risk and health‐seeking practices, especially in low‐ and middle‐income countries. Increasing evidence also highlights that
Barbara Honecker, Charlotte Sophie Hansen, Hanna Lotter   +2 more
wiley   +1 more source

Synthesis of a versatile (S)-3-(hydroxymethyl)butane-1,2,4-triol building block and its application for the stereoselective synthesis of N-homoceramides [PDF]

, 2005
A versatile (S)-3-(hydroxymethyl)butane-1,2,4-triol building block has been synthesized starting from D-isoascorbic acid, a common food preservative. The key transformation in this approach was the introduction of branching through a high yield and fully
Hillaert, Ulrik, Van Calenbergh, Serge
core   +1 more source