Results 121 to 130 of about 17,093 (242)
Administration of α-Galactosylceramide Improves Adenine-Induced Renal Injury
Molecular Medicine, 2015 Natural killer T (NKT) cells are a subset of lymphocytes that reacts to glycolipids presented by CD1d. Invariant NKT cells (iNKT) correspond to >90% of the total population of NKTs and reacts to α-galactosylceramide (αGalCer). αGalCer promotes a complex mixture of Th1 and Th2 cytokines, as interferon (IFN)-γ and interleukin (IL)-4.
Cristhiane Favero, Aguiar +11 more
openaire +2 more sources
Frontiers in Immunology, 2019 Background: Although myelin is composed of mostly lipids, the pathological role of myelin lipids in demyelinating diseases remains elusive. The principal lipid of the myelin sheath is β-galactosylceramide (β-Galcer).
Yi Ban +13 more
doaj +1 more source
CD1d- and MR1-restricted T Cells in Sepsis
Frontiers in Immunology, 2015 Dysregulated immune responses to infection such as those encountered in sepsis can be catastrophic. Sepsis is typically triggered by an overwhelming systemic response to an infectious agent(s) and is associated with high morbidity and mortality even ...
Peter A. Szabo +6 more
doaj +1 more source
Developing an On‐Resin Synthesis of α‐Galactosylceramide‐Peptide Conjugate Vaccines
ChemistryEuropeThe covalent attachment of peptide antigens to the NKT cell agonist, α‐galactosylceramide (αGalCer), generates self‐adjuvanting vaccines that prevent and/or eliminate disease in animal models of cancer and infectious disease.
Dr. Michael A. Meijlink +10 more
doaj +1 more source
Repeated administration of alpha-galactosylceramide ameliorates experimental lupus nephritis in mice
Scientific Reports, 2018 Lupus nephritis is a crucial complication of systemic lupus erythematosus. In this study, we investigated the roles of mouse natural killer T (NKT) cells in lupus nephritis.
Takahiro Uchida +8 more
doaj +1 more source
CD1d-antibody fusion proteins target iNKT cells to the tumor and trigger long-term therapeutic responses [PDF]
, 2018 Despite the well-established antitumor activity of CD1d-restricted invariant natural killer T lymphocytes (iNKT), their use for cancer therapy has remained challenging.
Corgnac, Stéphanie +9 more
core
International Journal of Biological Sciences, 2009 Purpose: The purpose of this study was to determine whether α-galactosylceramide (α-GalCer), a synthetic glycolipid agonist of natural killer T (NKT) cells, can ameliorate exercise-induced immune imbalance.
Wang Ru, Chen Peijie
doaj