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Galanthamin als AChE-Inhibitor

, 2011
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Galanthamine

Drugs & Aging, 1996
Galanthamine is a selective acetylcholinesterase inhibitor which has shown potential for the treatment of Alzheimer's disease. Galanthamine is selective for acetylcholinesterase versus butyrylcholinesterase; however, the drug produces greater enzyme inhibition in human erythrocytes than in human brain tissue.
B, Fulton, P, Benfield
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Total Synthesis of (±)-Galanthamine

Organic Letters, 2006
[reaction: see text] A practical and efficient total synthesis of (+/-)-galanthamine was achieved from commercially available materials through a novel approach, in which the construction of its core structure and the special allylic alcohol group were based on a successive semipinacol rearrangement/desilyation/cyclization and Saegusa-Ito oxidation ...
Xiang-Dong, Hu, Yong Qiang, Tu, En, Zhang, Shuanhu, Gao, Shaohua, Wang, Aixia, Wang, Chun-An, Fan, Min, Wang   +7 more
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Galanthamine treatment in Alzheimer’s disease

1991
18 patients who had fulfilled the NINCDS-ADRDA criteria for "possible AD" took part in a clinical study to evaluate the effect of the cholinesterase inhibitor Galanthamine, 30 mg/day. Neuropsychological und social parameters were rated. This open clinical pilot-study showed no statistic significant change in neuropsychological test-results.
P, Dal-Bianco, J, Maly, C, Wôber, C, Lind, G, Koch, J, Hufgard, I, Marschall, M, Mraz, L, Deecke   +8 more
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Review of the acetylcholinesterase inhibitor galanthamine

Expert Opinion on Investigational Drugs, 2000
Galanthamine (or galantamine, Reminyl) is a tertiary alkaloid acetylcholinesterase inhibitor (AChEI) which has been approved in several countries for the symptomatic treatment of senile dementia of the Alzheimer's type. Derived from bulbs of the common snowdrop and several Amaryllidaceae plants, (-)-galanthamine (GAL) has long been used in anaesthetics
J J, Sramek, E J, Frackiewicz, N R, Cutler   +2 more
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Syntheses of (‐)‐Galanthamine

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
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Zur Epimerisierung von Galanthamin

Chemische Berichte, 1964
AbstractDas kürzlich als 2‐Hydroxy‐4.5‐epoxy‐6‐O‐methyl‐tetrahydro‐apogalanthamin beschriebene Abbauprodukt aus Galanthamin wurde als (–)‐Epigalanthamin identifiziert.
Gert P. Volpp, Lilia Bubewa‐Iwanowa
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Wege zu (‐)‐Galanthamin

Nachrichten aus der Chemie, 2004
AbstractEine Zielstruktur, zwei Blickwinkel. Für Forscher aus Industrie und Hochschule zeigt sich die Totalsynthese des Anti‐Alzheimer‐Medikaments (‐)‐Galanthamin ganz unterschiedlich.
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Cholinesterase inhibition by galanthamine and lycoramine

Biochemical Pharmacology, 1960
Abstract Galanthamine, a recently isolated alkaloid, has been found to inhibit the acetylcholinesterase of muscle and the cholinesterase of plasma and brain. The inhibition of the muscle enzyme by galanthamine is greater than that produced by pyridostigmin, a compound of known usefulness, but less than that of neostigmin.
R L, IRWIN, H J, SMITH
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