Results 11 to 20 of about 35,521 (207)

Peripheral blood TIM-3 positive NK and CD8+ T cells throughout pregnancy: TIM-3/galectin-9 interaction and its possible role during pregnancy. [PDF]

PLoS ONE, 2014
The T-cell immunoglobulin and mucin domain (TIM) family is a relatively newly described group of molecules with a conserved structure and important immunological functions. Identification of Galectin-9 as a ligand for TIM-3 has established the Galectin-9/
Matyas Meggyes, Eva Miko, Beata Polgar, Barbara Bogar, Balint Farkas, Zsolt Illes, Laszlo Szereday   +6 more
doaj   +3 more sources

T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins [PDF]

Journal for ImmunoTherapy of Cancer, 2023
Background Galectin-9 is a member of the family of lectin proteins and crucially regulates human immune responses, particularly because of its ability to suppress the anticancer activities of T lymphocytes and natural killer cells.
Stephanie Schlichtner, Inna M Yasinska, Gurprit S Lall, Steffen M Berger, Sabrina Ruggiero, Dietmar Cholewa, Nijas Aliu, Bernhard F Gibbs, Elizaveta Fasler-Kan, Vadim V Sumbayev   +9 more
doaj   +4 more sources

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation. [PDF]

PLoS Pathogens, 2016
Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (ART),
Mohamed Abdel-Mohsen, Leonard Chavez, Ravi Tandon, Glen M Chew, Xutao Deng, Ali Danesh, Sheila Keating, Marion Lanteri, Michael L Samuels, Rebecca Hoh, Jonah B Sacha, Philip J Norris, Toshiro Niki, Cecilia M Shikuma, Mitsuomi Hirashima, Steven G Deeks, Lishomwa C Ndhlovu, Satish K Pillai   +17 more
doaj   +5 more sources

Galectin-9 binds IgM-BCR to regulate B cell signaling [PDF]

Nature Communications, 2018
The galectin family of secreted lectins are important regulators of immune cell function; however, their role in B cell responses is poorly understood. Here, the authors identify IgM-BCR as a ligand for galectin-9.
Anh Cao, Nouf Alluqmani, Fatima Hifza Mohammed Buhari, Laabiah Wasim, Logan K. Smith, Andrew T. Quaile, Michael Shannon, Zaki Hakim, Hossai Furmli, Dylan M. Owen, Alexei Savchenko, Bebhinn Treanor   +11 more
doaj   +5 more sources

A Fermented Milk Matrix Containing Postbiotics Supports Th1- and Th17-Type Immunity In Vitro and Modulates the Influenza-Specific Vaccination Response In Vivo in Association with Altered Serum Galectin Ratios

Vaccines, 2021
During a specific milk fermentation process with Bifidobacterium breve C50 and Streptococcus thermophilus 065 (LactofidusTM), postbiotics with possible immunomodulatory properties are produced. We investigated the effects of this fermentation product (FP)
Veronica Ayechu-Muruzabal, Ling Xiao, Tjalling Wehkamp, Ingrid van Ark, Elisabeth J. Hoogendoorn, Thea Leusink-Muis, Gert Folkerts, Johan Garssen, Linette E. M. Willemsen, Belinda van’t Land   +9 more
doaj   +1 more source

Plasma Galectin-9 Concentrations in Normal and Diseased Condition

Cellular Physiology and Biochemistry, 2018
Background/Aims: Galectin-9 is a soluble immune modulator with versatile functions, including a role as an immune checkpoint molecule. Therefore, the amount of galectin-9 in the blood may reflect an individual’s immunological balance.
Toshiro Niki, Koji Fujita, Hugo Rosen, Mitsuomi Hirashima, Tsutomu Masaki, Toshio Hattori, Katsuaki Hoshino   +6 more
doaj   +1 more source

Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer. [PDF]

PLoS ONE, 2015
Galectins are proteins that bind β-galactoside sugars and provide a new type of potential biomarkers and therapeutic targets in cancer. Galectin-1, -3 and -9 have become the focus of different research groups, but their expression and function in ...
Simone Punt, Victor L Thijssen, Johannes Vrolijk, Cornelis D de Kroon, Arko Gorter, Ekaterina S Jordanova   +5 more
doaj   +1 more source

Do Serum Galectin-9 Levels in Women with Gestational Diabetes and Healthy Ones Differ before or after Delivery? A Pilot Study

Biomolecules, 2023
Gestational diabetes mellitus (GDM) is a common metabolic disease that occurs during pregnancy, with the placenta playing an important role in its pathophysiology. Currently, the role of galectin-9 in the development of GDM is unknown.
Aleksandra Pełech, Monika Ruszała, Magdalena Niebrzydowska-Tatus, Katarzyna Bień, Żaneta Kimber-Trojnar, Monika Czuba, Małgorzata Świstowska, Bożena Leszczyńska-Gorzelak   +7 more
doaj   +1 more source

A new emerging target in cancer immunotherapy: Galectin-9 (LGALS9)

Genes and Diseases, 2023
Over the past few decades, advances in immunological knowledge have led to the identification of novel immune checkpoints, reinvigorating cancer immunotherapy.
Yan Lv, Xiao Ma, Yuxin Ma, Yuxin Du, Jifeng Feng   +4 more
doaj   +1 more source

Oral Administration of Fucoidan Can Exert Anti-Allergic Activity after Allergen Sensitization by Enhancement of Galectin-9 Secretion in Blood

Biomolecules, 2020
A previous study revealed that fucoidan inhibited mast cell degranulation through the upregulation of galectin-9 in blood. The purpose of this study is to elucidate its mechanism using ovalbumin (OVA) induced anaphylaxis model mice (BALB/c, Female, 5 ...
Masashi Mizuno, Kana Sakaguchi, Iwao Sakane   +2 more
doaj   +1 more source