Results 21 to 30 of about 35,521 (207)

The immune receptor Tim-3 acts as a trafficker in a Tim-3/galectin-9 autocrine loop in human myeloid leukemia cells [PDF]

, 2016
The immune receptor Tim-3 is often highly expressed in human acute myeloid leukemia (AML) cells where it acts as a growth factor and inflammatory receptor.
Bardelli, Marco, Berger, Steffen M., Fasler-Kan, Elizaveta, Fruehwirth, Alexander, Gibbs, Bernhard F., Gonçalves Silva, Isabel, Rüegg, Laura, Sumbayev, Vadim V., Varani, Luca   +8 more
core   +1 more source

PD-L1, Galectin-9 and CD8+ tumor-infiltrating lymphocytes are associated with survival in hepatocellular carcinoma [PDF]

, 2017
Novel systemic treatments for hepatocellular carcinoma (HCC) are strongly needed. Immunotherapy is a promising strategy that can induce specific antitumor immune responses.
Beuers, U. (Ulrich), Biermann, K. (Katharina), Boor, P.P.C. (Patrick), Bruno, M.J. (Marco), Buschow, S.I. (Sonja I.), Gulik, T.M. (Thomas) van, Hansen, B.E. (Bettina), IJzermans, J.N.M. (Jan), Kwekkeboom, J. (Jaap), Man, R.A. (Robert) de, Mancham, S. (Shanta), Pan, Q. (Qiuwei), Schutz, H.M. (Hannah M.), Sideras, K. (Kostandinos), Sleijfer, S. (Stefan), Sprengers, D. (Dave), Takkenberg, B.R. (Bart R.), Terkivatan, T. (Türkan), Verheij, J. (Joanne), Verseput, M.C.M. (Maddy C. M.)   +19 more
core   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Role of Galectins in the Liver Diseases: A Systematic Review and Meta-Analysis

Frontiers in Medicine, 2021
Background: Galectins, a family of β-galactoside-binding proteins, are related to the development and progression of various human diseases such as cancer, heart failure, and chronic kidney disease. However, its role in liver diseases is unclear.Methods:
Yang An, Yang An, Shixue Xu, Yiting Liu, Yiting Liu, Xiangbo Xu, Xiangbo Xu, Cyriac Abby Philips, Jiang Chen, Nahum Méndez-Sánchez, Xiaozhong Guo, Xingshun Qi   +11 more
doaj   +1 more source

Differential expression and biochemical activity of the immune receptor Tim-3 in healthy and malignant human myeloid cells [PDF]

, 2015
The T cell immunoglobulin and mucin domain 3 (Tim-3) is a plasma membrane-associated receptor which is involved in a variety of biological responses in human immune cells.
Bardelli, Marco, Gibbs, Bernhard F, Goncalves Silva, Isabel, Sumbayev, Vadim V., Varani, Luca   +4 more
core   +2 more sources

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

EZH2 promotes hepatocellular carcinoma progression through modulating miR-22/galectin-9 axis

Journal of Experimental & Clinical Cancer Research, 2018
Background Recent studies have shown that interferon-γ (IFN-γ)-induced galectin-9 expression in Kupffer cells plays an essential role in modulatingthe microenvironment of hepatitis-associated hepatocellular carcinoma (HCC).
Shaofei Chen, Jiarui Pu, Jie Bai, Yuping Yin, Ke Wu, Jiliang Wang, Xiaoming Shuai, Jinbo Gao, Kaixiong Tao, Guobin Wang, Hang Li   +10 more
doaj   +1 more source

Galectin-14 Promotes Trophoblast Migration and Invasion by Upregulating the Expression of MMP-9 and N-Cadherin

Frontiers in Cell and Developmental Biology, 2021
Galectin-14 is specifically expressed in placental trophoblasts, and its expression is reduced in trophoblasts retrieved from the cervix of women destined to develop early pregnancy loss.
Miaomiao Wang, Yuqing Xu, Peng Wang, Yanfei Xu, Pengzhen Jin, Zaigui Wu, Yeqing Qian, Yeqing Qian, Yeqing Qian, Long Bai, Long Bai, Minyue Dong, Minyue Dong, Minyue Dong   +13 more
doaj   +1 more source

Tumor-induced senescent T cells promote the secretion of pro-inflammatory cytokines and angiogenic factors by human monocytes/macrophages through a mechanism that involves Tim-3 and CD40L [PDF]

, 2014
Solid tumors are infiltrated by immune cells where macrophages and senescent T cells are highly represented. Within the tumor microenvironment, a cross-talk between the infiltrating cells may occur conditioning the characteristic of the in situ immune ...
Acosta Rodriguez, Eva Virginia, Canale, Fernando Pablo, Gastman, B, Gruppi, Adriana, Mena, Hebe Agustina, Montes, Carolina Lucia, Negrotto, Soledad, Ramello, María Cecilia, Tosello Boari, Jimena   +8 more
core   +2 more sources

Intracellular Galectin-9 Controls Dendritic Cell Function by Maintaining Plasma Membrane Rigidity

iScience, 2019
Summary: Endogenous extracellular Galectins constitute a novel mechanism of membrane protein organization at the cell surface. Although Galectins are also highly expressed intracellularly, their cytosolic functions are poorly understood.
Laia Querol Cano, Oya Tagit, Yusuf Dolen, Anne van Duffelen, Shannon Dieltjes, Sonja I. Buschow, Toshiro Niki, Mitsuomi Hirashima, Ben Joosten, Koen van den Dries, Alessandra Cambi, Carl G. Figdor, Annemiek B. van Spriel   +12 more
doaj   +1 more source