Results 61 to 70 of about 4,219,302 (284)

Regulated expression of galectin-1 after in vitro productive infection with herpes simplex virus type 1: implications for T cell apoptosis [PDF]

, 2005
Apoptosis of cytotoxic T lymphocytes by herpes simplex virus type-1 (HSV-1) has been reported to be a relevant mechanism of viral immune evasion. Galectin-1 (Gal-1), an endogenous lectin involved in T-cell apoptosis, has recently gained considerable ...
Gonzalez, Maria Ines, Ilarregui, Juan Martin, Rabinovich, Gabriel Adrián, Rubinstein, Natalia, Sanjuan, Norberto Aníbal, Toscano, Marta Alicia   +5 more
core   +1 more source

Human T cell glycosylation and implications on immune therapy for cancer [PDF]

, 2020
Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome.
Callewaert, Nico, De Bousser, Elien, Festjens, Nele, Meuris, Leander   +3 more
core   +1 more source

Development and characterization of anti-galectin-9 antibodies that protect T cells from galectin-9-induced cell death

Journal of Biological Chemistry, 2022
Antibodies that target immune checkpoint proteins such as programmed cell death protein 1, programmed death ligand 1, and cytotoxic T-lymphocyte-associated antigen 4 in human cancers have achieved impressive clinical success; however, a significant proportion of patients fail to respond to these treatments.
Riyao Yang, Linlin Sun, Ching-Fei Li, Yu-Han Wang, Weiya Xia, Boning Liu, Yu-Yi Chu, Laura Bover, Long Vien, Mien-Chie Hung   +9 more
openaire   +2 more sources

Sensing of mycobacterial arabinogalactan by galectin‐9 exacerbates mycobacterial infection [PDF]

EMBO reports, 2021
Mycobacterial arabinogalactan (AG) is an essential cell wall component of mycobacteria and a frequent structural and bio-synthetical target for anti-tuberculosis (TB) drug development. Here, we report that mycobacterial AG is recognized by galectin-9 and exacerbates mycobacterial infection.
Xiangyang Wu, Yong Wu, Ruijuan Zheng, Fengyan Tang, Lianhua Qin, Detian Lai, Lu Zhang, Lingming Chen, Bo Yan, Hua Yang, Yang Wang, Feifei Li, Jinyu Zhang, Fei Wang, Lin Wang, Yinhe Cao, Mingtong Ma, Liu Z, Jianxia Chen, Xiaochen Huang, Jie Wang, Ruo‐Shui Jin, Peng Wang, Qin Sun, Sha Wang, Liang-Dong Lyu, Pedro Moura‐Alves, Anca Dorhoi, Gang Pei, Peng Zhang, Jiayu Chen, Shaorong Gao, Felix Randow, Gucheng Zeng, Chang Chen, Xin‐Shan Ye, Stefan H. E. Kaufmann, Haipeng Liu, Baoxue Ge   +38 more
openaire   +4 more sources

Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection

mBio, 2021
The outbreak of SARS-CoV-2 infection has enormously impacted our lives. Clinical evidence has implicated the emergence of cytokine release syndrome as the prominent cause of mortality in COVID-19 patients.
Najmeh Bozorgmehr, Siavash Mashhouri, Eliana Perez Rosero, Lai Xu, S. Shahbaz, Wendy Sligl, M. Osman, D. Kutsogiannis, E. MacIntyre, C. O’Neil, S. Elahi   +10 more
semanticscholar   +1 more source

Tim3 binding to galectin-9 stimulates antimicrobial immunity [PDF]

Journal of Experimental Medicine, 2010
T cell immunoglobulin and mucin domain 3 (Tim3) is a negative regulatory molecule that inhibits effector TH1-type responses. Such inhibitory signals prevent unintended tissue inflammation, but can be detrimental if they lead to premature T cell exhaustion.
Jayaraman, Pushpa, Sada-Ovalle, Isabel, Beladi, Sarah, Anderson, Ana C., Dardalhon, Valerie, Hotta, Chie, Kuchroo, Vijay K., Behar, Samuel M.   +7 more
openaire   +2 more sources

Functions of cell surface galectin-glycoprotein lattices [PDF]

, 2007
Programmed remodeling of cell surface glycans by the sequential action of specific glycosyltransferases can control biological processes by generating or masking ligands for endogenous lectins. Galectins, a family of animal lectins with affinity for beta-
Jackson, Shawn S., Rabinovich, Gabriel Adrián, Toscano, Marta Alicia, Vasta, Gerardo R.   +3 more
core   +1 more source

Influence of Galectin-9 Treatment on the Phenotype and Function of NK-92MI Cells in the Presence of Different Serum Supplements

Biomolecules, 2021
Galectins are one of the critical players in the tumor microenvironment–tumor crosstalk and the regulation of local immunity. Galectin-9 has been in the limelight in tumor immunology.
Matyas Meggyes, David U Nagy, Timea Balassa, Krisztina Godony, Agnes Peterfalvi, Laszlo Szereday, Beata Polgar   +6 more
doaj   +1 more source

CXC chemokine ligand 13 and galectin-9 plasma levels collaboratively provide prediction of disease activity and progression-free survival in chronic lymphocytic leukemia

Annals of Hematology, 2023
The clinical outcome of lymphocytic leukemia (CLL) is quite heterogeneous. The purpose of this observational study was to investigate the clinical merit of measuring plasma galectin-9 and CXCL-13 concentrations as predictors of CLL activity, prognosis ...
Heba A Ahmed, A. Nafady, Eman H. Ahmed, Emad Eldin Nabil Hassan, W. Soliman, Mahmoud I Elbadry, A. A. Allam   +6 more
semanticscholar   +1 more source

Galectin-9 inhibits cell proliferation and induces apoptosis in Jurkat and KE-37 acute lymphoblastic leukemia cell lines via caspase-3 activation

Research in Pharmaceutical Sciences, 2021
Background and purpose: Acute lymphoblastic leukemia (ALL) is a type of cancer of blood and bone marrow characterized by abnormal proliferation of lymphoid progenitor cells. Galectin-9 is a tandem-repeat type galectin expressed in various tumor cells. It
Narges Zargar Balajam, Mahdi Shabani, Mahmoud Aghaei   +2 more
doaj   +1 more source