Results 61 to 70 of about 4,689,501 (274)

IMMUNOLOGICAL ASPECTS OF CROHN'S DISEASE: A REGULATORY FUNCTION OF TIM-3/GALECTIN-9 IN LYTH1. [PDF]

, 2017
Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) and its etiology is multifactorial and involves a combination of genetic environmental factors.
Carini, F., David, S., Gagliardo, C., Geagea, A., Jurjus, A., Leone, A., Lo Presti, E., Mazzola, M., Rappa, F., Scaglione, M., Tomasello, G., Zerbe, R.   +11 more
core   +1 more source

Sensing of mycobacterial arabinogalactan by galectin‐9 exacerbates mycobacterial infection [PDF]

EMBO reports, 2021
Mycobacterial arabinogalactan (AG) is an essential cell wall component of mycobacteria and a frequent structural and bio-synthetical target for anti-tuberculosis (TB) drug development. Here, we report that mycobacterial AG is recognized by galectin-9 and exacerbates mycobacterial infection.
Xiangyang Wu, Yong Wu, Ruijuan Zheng, Fengyan Tang, Lianhua Qin, Detian Lai, Lu Zhang, Lingming Chen, Bo Yan, Hua Yang, Yang Wang, Feifei Li, Jinyu Zhang, Fei Wang, Lin Wang, Yinhe Cao, Mingtong Ma, Liu Z, Jianxia Chen, Xiaochen Huang, Jie Wang, Ruo‐Shui Jin, Peng Wang, Qin Sun, Sha Wang, Liang-Dong Lyu, Pedro Moura‐Alves, Anca Dorhoi, Gang Pei, Peng Zhang, Jiayu Chen, Shaorong Gao, Felix Randow, Gucheng Zeng, Chang Chen, Xin‐Shan Ye, Stefan H. E. Kaufmann, Haipeng Liu, Baoxue Ge   +38 more
openaire   +4 more sources

Regulated expression of galectin-1 after in vitro productive infection with herpes simplex virus type 1: implications for T cell apoptosis [PDF]

, 2005
Apoptosis of cytotoxic T lymphocytes by herpes simplex virus type-1 (HSV-1) has been reported to be a relevant mechanism of viral immune evasion. Galectin-1 (Gal-1), an endogenous lectin involved in T-cell apoptosis, has recently gained considerable ...
Gonzalez, Maria Ines, Ilarregui, Juan Martin, Rabinovich, Gabriel Adrián, Rubinstein, Natalia, Sanjuan, Norberto Aníbal, Toscano, Marta Alicia   +5 more
core   +1 more source

Tim3 binding to galectin-9 stimulates antimicrobial immunity [PDF]

Journal of Experimental Medicine, 2010
T cell immunoglobulin and mucin domain 3 (Tim3) is a negative regulatory molecule that inhibits effector TH1-type responses. Such inhibitory signals prevent unintended tissue inflammation, but can be detrimental if they lead to premature T cell exhaustion.
Jayaraman, Pushpa, Sada-Ovalle, Isabel, Beladi, Sarah, Anderson, Ana C., Dardalhon, Valerie, Hotta, Chie, Kuchroo, Vijay K., Behar, Samuel M.   +7 more
openaire   +2 more sources

Influence of Galectin-9 Treatment on the Phenotype and Function of NK-92MI Cells in the Presence of Different Serum Supplements

Biomolecules, 2021
Galectins are one of the critical players in the tumor microenvironment–tumor crosstalk and the regulation of local immunity. Galectin-9 has been in the limelight in tumor immunology.
Matyas Meggyes, David U Nagy, Timea Balassa, Krisztina Godony, Agnes Peterfalvi, Laszlo Szereday, Beata Polgar   +6 more
doaj   +1 more source

Proteomic and epigenomic markers of sepsis-induced delirium (SID) [PDF]

, 2015
In elderly population sepsis is one of the leading causes of intensive care unit (ICU) admissions in the United States. Sepsis-induced delirium (SID) is the most frequent cause of delirium in ICU (Martin et al., 2010). Together delirium and SID represent
Adonis eSfera, Amy I Price, Carolina eOsorio, Michael eCummings, Roberto eGradini, Roberto eGradini   +5 more
core   +2 more sources

Galectin-9 inhibits cell proliferation and induces apoptosis in Jurkat and KE-37 acute lymphoblastic leukemia cell lines via caspase-3 activation

Research in Pharmaceutical Sciences, 2021
Background and purpose: Acute lymphoblastic leukemia (ALL) is a type of cancer of blood and bone marrow characterized by abnormal proliferation of lymphoid progenitor cells. Galectin-9 is a tandem-repeat type galectin expressed in various tumor cells. It
Narges Zargar Balajam, Mahdi Shabani, Mahmoud Aghaei   +2 more
doaj   +1 more source

Lactose-Functionalized Carbosilane Glycodendrimers Are Highly Potent Multivalent Ligands for Galectin-9 Binding: Increased Glycan Affinity to Galectins Correlates with Aggregation Behavior

Biomacromolecules, 2023
Galectins, the glycan binding proteins, and their respective carbohydrate ligands represent a unique fundamental regulatory network modulating a plethora of biological processes.
Monika Müllerová, M. Hovorková, Táňa Závodná, Lucie Červenková Št Astná, A. Krupková, Vojtěch Hamala, Kateřina Nováková, J. Topinka, P. Bojarová, Tomáš Strašák   +9 more
semanticscholar   +1 more source

Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes. [PDF]

, 2011
Carbohydrate derivatisation and glycocluster formation are both known to enhance avidity for lectin binding. Using a plant toxin and human adhesion/growth-regulatory lectins (inter- and intrafamily comparisons) the effect of their combination is examined.
André, André, André, André, Cumpstey, Cyrille Grandjean, Dam, Delacour, Fort, Francesco Sansone, François-Moana Gautier, Fulton, Gabius, Galanina, Gautier, Gupta, Hans-Joachim Gabius, Hirabayashi, Jiménez, Kopitz, Krzeminski, Leyden, Oda, Patnaik, Rocco Ungaro, Sabine André, Sanchez-Ruderisch, Sansone, Silvia Bernardi, Sparrow, Sörme, Villalobo, Wu, Wu, Yamazaki   +34 more
core   +3 more sources

Galectin-9 as a Potential Modulator of Lymphocyte Adhesion to Endothelium via Binding to Blood Group H Glycan

Biomolecules, 2023
The recruitment of leukocytes from blood is one of the most important cellular processes in response to tissue damage and inflammation. This multi-step process includes rolling leukocytes and their adhesion to endothelial cells (EC), culminating in ...
E. Rapoport, I. Ryzhov, E. V. Slivka, E. Korchagina, I. Popova, S. Khaidukov, S. André, H. Kaltner, H. Gabius, S. Henry, N. Bovin   +10 more
semanticscholar   +1 more source