Results 71 to 80 of about 4,219,302 (284)

Proteomic and epigenomic markers of sepsis-induced delirium (SID) [PDF]

, 2015
In elderly population sepsis is one of the leading causes of intensive care unit (ICU) admissions in the United States. Sepsis-induced delirium (SID) is the most frequent cause of delirium in ICU (Martin et al., 2010). Together delirium and SID represent
Adonis eSfera, Amy I Price, Carolina eOsorio, Michael eCummings, Roberto eGradini, Roberto eGradini   +5 more
core   +2 more sources

High-dimensional single-cell definition of CLL T cells identifies Galectin-9 as novel immunotherapy target

bioRxiv, 2023
Failure of cancer immunotherapy is linked to T cell exhaustion. To decipher the underlying mechanisms, we explored the T cell landscape in blood, bone marrow and lymph node samples of patients with chronic lymphocytic leukemia (CLL), and spleen samples ...
L. Llaó Cid, J. Wong, I. Fernandez Botana, Y. Paul, M. Wierz, A. Flörchinger, S. Gonder, G. Pagano, M. Chazotte, K. Bestak, C. Schifflers, M. Iskar, T. Roider, F. Czernilofsky, Bruch P-M, JP Mallm, A. Cosma, DE Campton, E. Gerhard-Hartmann, A. Rosenwald, D. Colomer, E. Campo, D. Schapiro, S. Dietrich, P. Lichter, E. Moussay, J. Paggetti, M. Zapatka, M. Seiffert   +28 more
semanticscholar   +1 more source

Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease [PDF]

, 2013
Background: Galectin-9 (Gal-9) induces apoptosis in activated T helper 1 (T(H)1) cells as a ligand for T cell immunoglobulin mucin-3 (Tim-3). Gal-9 also inhibits the G1 phase cell cycle arrest and hypertrophy in db/db mice, the hallmark of early diabetic
A Sanchez-Fueyo, Akihiro Katayama, AS Levey, Atsuko Nakatsuka, C Zhu, Chigusa Higuchi, F Wang, Hirofumi Makino, J Klibi, J Wada, J Wada, JA Mengshol, Jun Eguchi, Jun Wada, K Igawa, Kazutoshi Murakami, Kentaro Inoue, M Baba, M Kanzaki, Mayu Watanabe, Motoko Kanzaki, Nobuyuki Miyatake, O Tureci, P Jayaraman, S de Kivit, S Matsuo, S Sehrawat, Sanae Teshigawara, SH Barondes, T Imaizumi, Takahiro Terami, WJ Chirico, Y Tsuchiyama, Yuko Kurose   +33 more
core   +2 more sources

Lactose-Functionalized Carbosilane Glycodendrimers Are Highly Potent Multivalent Ligands for Galectin-9 Binding: Increased Glycan Affinity to Galectins Correlates with Aggregation Behavior

Biomacromolecules, 2023
Galectins, the glycan binding proteins, and their respective carbohydrate ligands represent a unique fundamental regulatory network modulating a plethora of biological processes.
Monika Müllerová, M. Hovorková, Táňa Závodná, Lucie Červenková Št Astná, A. Krupková, Vojtěch Hamala, Kateřina Nováková, J. Topinka, P. Bojarová, Tomáš Strašák   +9 more
semanticscholar   +1 more source

Cell Surface Galectin-9 Expressing Th Cells Regulate Th17 and Foxp3+ Treg Development by Galectin-9 Secretion

PLoS ONE, 2012
Galectin-9 (Gal-9), a β-galactoside binding mammalian lectin, regulates immune responses by reducing pro-inflammatory IL-17-producing Th cells (Th17) and increasing anti-inflammatory Foxp3(+) regulatory T cells (Treg) in vitro and in vivo. These functions of Gal-9 are thought to be exerted by binding to receptor molecules on the cell surface.
Souichi Oomizu, Tomohiro Arikawa, Toshiro Niki, Takeshi Kadowaki, Masaki Ueno, Nozomu Nishi, Akira Yamauchi, Toshio Hattori, Tsutomu Masaki, Mitsuomi Hirashima   +9 more
openaire   +4 more sources

Restriction of Human Cytomegalovirus Infection by Galectin-9 [PDF]

Journal of Virology, 2019
Human cytomegalovirus (HCMV) continues to cause serious and often life-threatening disease in those with impaired or underdeveloped immune systems. This virus is able to infect and replicate in a wide range of human cell types, which enables the virus to spread to other individuals in a number of settings.
Emily A. Machala, Selmir Avdic, Lauren Stern, Dirk M. Zajonc, Chris A. Benedict, Emily Blyth, David J. Gottlieb, Allison Abendroth, Brian P. McSharry, Barry Slobedman   +9 more
openaire   +2 more sources

Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes. [PDF]

, 2011
Carbohydrate derivatisation and glycocluster formation are both known to enhance avidity for lectin binding. Using a plant toxin and human adhesion/growth-regulatory lectins (inter- and intrafamily comparisons) the effect of their combination is examined.
André, André, André, André, Cumpstey, Cyrille Grandjean, Dam, Delacour, Fort, Francesco Sansone, François-Moana Gautier, Fulton, Gabius, Galanina, Gautier, Gupta, Hans-Joachim Gabius, Hirabayashi, Jiménez, Kopitz, Krzeminski, Leyden, Oda, Patnaik, Rocco Ungaro, Sabine André, Sanchez-Ruderisch, Sansone, Silvia Bernardi, Sparrow, Sörme, Villalobo, Wu, Wu, Yamazaki   +34 more
core   +3 more sources

Antiretroviral Treatment-Induced Galectin-9 Might Impact HIV Viremia in Addition to Contributing to Inflammaging

International Journal of Molecular Sciences, 2023
Background: Galectin-9 induces HIV reactivation and also contributes to non-AIDS events through inflammaging. Hence, it is important to assess its levels in HIV-infected individuals to determine their association with HIV viremia and other comorbidities.
A. Shete, Vaishnav Wagh, Jyoti Sawant, P. Shidhaye, S. Sane, A. Rao, S. Kulkarni, M. Ghate   +7 more
semanticscholar   +1 more source

Galectin-9 in autoimmune hepatitis

Medicine, 2019
Abstract Autoimmune hepatitis (AIH) is a disorder of unknown etiology in which immune-mediated liver damage progresses to cirrhosis or hepatocellular carcinoma (HCC). The mainstay therapy for AIH is steroids and other immunosuppressive treatments.
Matsuoka, Naoki, Kozuru, Hideko, Koga, Tomohiro, Abiru, Seigo, Yamasaki, Kazumi, Komori, Atsumasa, Fujita, Yuya, Tenmoku, Junpei, Asano, Tomoyuki, Sato, Shuzo, Suzuki, Eiji, Furuya, Makiko, Kobayashi, Hiroko, Watanabe, Hiroshi, Naganuma, Atsushi, Yoshizawa, Kaname, Shimada, Masaaki, Ario, Keisuke, Yamashita, Haruhiro, Kohno, Hiroshi, Kaneyoshi, Toshihiko, Nakamura, Minoru, Furukawa, Hiroshi, Takahashi, Atsushi, Kawakami, Atsushi, Ohira, Hiromasa, Yatsuhashi, Hiroshi, Migita, Kiyoshi   +27 more
openaire   +2 more sources

mGBP2 engages Galectin-9 for immunity against Toxoplasma gondii. [PDF]

PLoS One
Guanylate binding proteins (GBPs) are large interferon-inducible GTPases, executing essential host defense activities against Toxoplasma gondii, an invasive intracellular apicomplexan protozoan parasite of global importance. T. gondii establishes a parasitophorous vacuole (PV) which shields the parasite from the host’s intracellular defense mechanisms.
Kravets E, Poschmann G, Hänsch S, Raba V, Weidtkamp-Peters S, Degrandi D, Stühler K, Pfeffer K.   +7 more
europepmc   +4 more sources