Results 71 to 80 of about 4,689,501 (274)

Cell Surface Galectin-9 Expressing Th Cells Regulate Th17 and Foxp3+ Treg Development by Galectin-9 Secretion

PLoS ONE, 2012
Galectin-9 (Gal-9), a β-galactoside binding mammalian lectin, regulates immune responses by reducing pro-inflammatory IL-17-producing Th cells (Th17) and increasing anti-inflammatory Foxp3(+) regulatory T cells (Treg) in vitro and in vivo. These functions of Gal-9 are thought to be exerted by binding to receptor molecules on the cell surface.
Souichi Oomizu, Tomohiro Arikawa, Toshiro Niki, Takeshi Kadowaki, Masaki Ueno, Nozomu Nishi, Akira Yamauchi, Toshio Hattori, Tsutomu Masaki, Mitsuomi Hirashima   +9 more
openaire   +4 more sources

Restriction of Human Cytomegalovirus Infection by Galectin-9 [PDF]

Journal of Virology, 2019
Human cytomegalovirus (HCMV) continues to cause serious and often life-threatening disease in those with impaired or underdeveloped immune systems. This virus is able to infect and replicate in a wide range of human cell types, which enables the virus to spread to other individuals in a number of settings.
Emily A. Machala, Selmir Avdic, Lauren Stern, Dirk M. Zajonc, Chris A. Benedict, Emily Blyth, David J. Gottlieb, Allison Abendroth, Brian P. McSharry, Barry Slobedman   +9 more
openaire   +2 more sources

Galectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins

Nature Communications, 2022
Autophagy has been linked to a wide range of functions, including a degradative process that defends host cells against pathogens. Although the involvement of autophagy in HBV infection has become apparent, it remains unknown whether selective autophagy ...
K. Miyakawa, M. Nishi, Michinaga Ogawa, Satoko Matsunaga, M. Sugiyama, H. Nishitsuji, Hirokazu Kimura, M. Ohnishi, Koichi Watashi, K. Shimotohno, T. Wakita, A. Ryo   +11 more
semanticscholar   +1 more source

Galectin-9 in autoimmune hepatitis

Medicine, 2019
Abstract Autoimmune hepatitis (AIH) is a disorder of unknown etiology in which immune-mediated liver damage progresses to cirrhosis or hepatocellular carcinoma (HCC). The mainstay therapy for AIH is steroids and other immunosuppressive treatments.
Matsuoka, Naoki, Kozuru, Hideko, Koga, Tomohiro, Abiru, Seigo, Yamasaki, Kazumi, Komori, Atsumasa, Fujita, Yuya, Tenmoku, Junpei, Asano, Tomoyuki, Sato, Shuzo, Suzuki, Eiji, Furuya, Makiko, Kobayashi, Hiroko, Watanabe, Hiroshi, Naganuma, Atsushi, Yoshizawa, Kaname, Shimada, Masaaki, Ario, Keisuke, Yamashita, Haruhiro, Kohno, Hiroshi, Kaneyoshi, Toshihiko, Nakamura, Minoru, Furukawa, Hiroshi, Takahashi, Atsushi, Kawakami, Atsushi, Ohira, Hiromasa, Yatsuhashi, Hiroshi, Migita, Kiyoshi   +27 more
openaire   +2 more sources

A novel monoclonal antibody for detection of galectin-9 in tissue sections: application to human tissues infected by oncogenic viruses

Infectious Agents and Cancer, 2012
Background Galectin-9 is a mammalian lectin which possesses immunosuppressive properties. Excessive production of galectin-9 has been reported in two types of human virus-associated diseases chronic hepatitis C and nasopharyngeal carcinoma associated to ...
Barjon Clément, Niki Toshiro, Vérillaud Benjamin, Opolon Paule, Bedossa Pierre, Hirashima Mitsuomi, Blanchin Stéphanie, Wassef Michel, Rosen Hugo R, Jimenez Anne-Sophie, Wei Ming, Busson Pierre   +11 more
doaj   +1 more source

Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease [PDF]

, 2013
Background: Galectin-9 (Gal-9) induces apoptosis in activated T helper 1 (T(H)1) cells as a ligand for T cell immunoglobulin mucin-3 (Tim-3). Gal-9 also inhibits the G1 phase cell cycle arrest and hypertrophy in db/db mice, the hallmark of early diabetic
A Sanchez-Fueyo, Akihiro Katayama, AS Levey, Atsuko Nakatsuka, C Zhu, Chigusa Higuchi, F Wang, Hirofumi Makino, J Klibi, J Wada, J Wada, JA Mengshol, Jun Eguchi, Jun Wada, K Igawa, Kazutoshi Murakami, Kentaro Inoue, M Baba, M Kanzaki, Mayu Watanabe, Motoko Kanzaki, Nobuyuki Miyatake, O Tureci, P Jayaraman, S de Kivit, S Matsuo, S Sehrawat, Sanae Teshigawara, SH Barondes, T Imaizumi, Takahiro Terami, WJ Chirico, Y Tsuchiyama, Yuko Kurose   +33 more
core   +2 more sources

Therapeutic potential of Galectin‐9 in human disease

Medicinal Research Reviews, 2011
In recent years, an important role has emerged for the glycan‐binding protein Galectin‐9 (Gal‐9) in health and disease. In normal physiology, Gal‐9 seems to be a pivotal modulator of T‐cell immunity by inducing apoptosis in specific T‐cell subpopulations. Because these T‐cell populations are associated with autoimmunity, inflammatory disease, and graft
Wiersma, Valerie R., de Bruyn, Marco, Helfrich, Wijnand, Bremer, Edwin   +3 more
openaire   +3 more sources

Clinical Significance of Serum Galectin-9 and Soluble CD155 Levels in Patients with Systemic Sclerosis

Journal of Immunology Research, 2018
Signaling through coinhibitory receptors downregulates the immune response to prevent excessive immune activation and maintain optimal immunity and tolerance.
Mami Chihara, Miki Kurita, Yuki Yoshihara, Akihiko Asahina, Koichi Yanaba   +4 more
doaj   +1 more source

Modulation of porcine intestinal epitheliocytes immunetranscriptome response by Lactobacillus jensenii TL2937 [PDF]

, 2016
In order to evaluate probiotic strains applicable for the beneficial immunomodulation of the porcine gut (immunobiotics), we previously developed a porcine intestinal epitheliocyte cell line (PIE cells).
Albarracín, Leonardo Miguel, Aso, Hisashi, Ikeda-Ohtsubo, Wakako, Kanmani, Paulraj, Kano, Hiroshi, Kitazawa, Haruki, Kobayashi, Hisakazu, Kober, Humayun A.K.M., Makino, Seiya, Nochi, Tomonori, Ohkawara, Sou, Saito, Tadao, Sato, Nana, Suda, Yoshihito, Villena, Julio Cesar   +14 more
core   +1 more source

Galectin-9 Is a Novel Regulator of Epithelial Restitution [PDF]

The American Journal of Pathology, 2020
Increasingly, the ß-galactoside binding lectins, termed galectins, are being recognized as critical regulators of cell function and organismal homeostasis. Within the context of the mucosal surface, galectins are established regulators of innate and adaptive immune responses, microbial populations, and several critical epithelial functions, including ...
Brian S. Robinson, Bejan Saeedi, Connie M. Arthur, Josh Owens, Crystal Naudin, Nourine Ahmed, Liping Luo, Rheinallt Jones, Andrew Neish, Sean R. Stowell   +9 more
openaire   +2 more sources