Results 81 to 90 of about 4,689,501 (274)

Immunomodulator Galectin-9 is Increased in Blood and Skin of Patients with Bullous Pemphigoid

Acta Dermato-Venereologica, 2021
Massive recruitment of eosinophils into the dermis is a hallmark of bullous pemphigoid pathogenesis. Identifying the chemoattractant(s) guiding eosinophils into the skin in bullous pemphigoid is a prerequisite to thera­peutic targeting of eosinophil ...
Jasper Pruessmann, Wiebke Pruessmann, Maike M. Holtsche, Beke Linnemann, Christoph M. Hammers, Nina van Beek, Detlef Zillikens, Enno Schmidt, Christian D. Sadik   +8 more
doaj   +1 more source

mGBP2 engages Galectin-9 for immunity against Toxoplasma gondii. [PDF]

PLoS One
Guanylate binding proteins (GBPs) are large interferon-inducible GTPases, executing essential host defense activities against Toxoplasma gondii, an invasive intracellular apicomplexan protozoan parasite of global importance. T. gondii establishes a parasitophorous vacuole (PV) which shields the parasite from the host’s intracellular defense mechanisms.
Kravets E, Poschmann G, Hänsch S, Raba V, Weidtkamp-Peters S, Degrandi D, Stühler K, Pfeffer K.   +7 more
europepmc   +4 more sources

Graves' disease is associated with a defective expression of the immune regulatory molecule galectin-9 in antigen-presenting dendritic cells [PDF]

, 2015
Introduction Patients with autoimmune thyroid disease (AITD) show defects in their immune-regulatory mechanisms. Herein we assessed the expression and function of galectin-1 and galectin-9 (Gal-1, Gal-9) in dendritic cells (DCs) from patients with ...
Ana Ramos-Levi, Ana Rodríguez-Muñoz, Ana Serrano, AP Weetman, BS Prabhakar, C Blaser, C Mao, D Cooper, FC Chou, Francisco Sánchez-Madrid, GA Rabinovich, H de la Fuente, Hortensia de la Fuente, ID Mascanfroni, J van der Leij, L Bartalena, L Monney, LV Norling, M Demetriou, M Kanzaki, M Marazuela, M Ruiz-Riol, M Seki, M Seki, MA Toscano, Miguel Sampedro-Nuñez, Mónica Marazuela, N Figueroa-Vega, N Figueroa-Vega, NL Perillo, Roberto González-Amaro, S Katoh, S Leskela, Silke Appel, Susanna Leskela, T Arikawa, T Imaizumi, WM Wiersinga   +37 more
core   +5 more sources

Pathogenic role of exosomes in Epstein-Barr Virus (EBV)-associated cancers [PDF]

, 2017
Exosomes are 40- to 100-nm membrane-bound small vesicles that carry a great variety of cellular cargoes including proteins, DNA, messenger RNAs (mRNAs), and microRNAs (miRNAs).
Khoo, Alan Soo Beng, Liew, Kitson, Peh, Suat Cheng *, Teow, Sin Yeang *   +3 more
core   +1 more source

Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection

mBio, 2021
The outbreak of SARS-CoV-2 infection has enormously impacted our lives. Clinical evidence has implicated the emergence of cytokine release syndrome as the prominent cause of mortality in COVID-19 patients.
N. Bozorgmehr, Siavash Mashhouri, Eliana Perez Rosero, Lai Xu, S. Shahbaz, Wendy Sligl, M. Osman, D. Kutsogiannis, E. MacIntyre, C. O’Neil, S. Elahi   +10 more
semanticscholar   +1 more source

A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection. [PDF]

PLoS ONE, 2010
Approximately 200 million people throughout the world are infected with hepatitis C virus (HCV). One of the most striking features of HCV infection is its high propensity to establish persistence (approximately 70-80%) and progressive liver injury ...
John A Mengshol, Lucy Golden-Mason, Tomohiro Arikawa, Maxwell Smith, Toshiro Niki, Ryan McWilliams, Jessica A Randall, Rachel McMahan, Michael A Zimmerman, Manu Rangachari, Evgenia Dobrinskikh, Pierre Busson, Stephen J Polyak, Mitsuomi Hirashima, Hugo R Rosen   +14 more
doaj   +1 more source

Immunoregulation of Dendritic Cell Subsets by Inhibitory Receptors in Urothelial Cancer. [PDF]

, 2017
Blockade of inhibitory receptors (IRs) overexpressed by T cells can activate antitumor immune responses, resulting in the most promising therapeutic approaches, particularly in bladder cancer, currently able to extend patient survival.
Bohner, P., Cesson, V., Chevalier, M.F., Dartiguenave, F., De Leval, L., Derré, L., Gharbi, D., Gourmaud, J., Jichlinski, P., Legris, A.S., Lhermitte, B., Martin, V., Nardelli-Haefliger, D., Nobile, A., Pieraerts, C., Rotman, S., Speiser, D.E.   +16 more
core   +1 more source

Galectin-9 in cancer therapy: from immune checkpoint ligand to promising therapeutic target

Frontiers in Cell and Developmental Biology
Galectin-9 (Gal-9) is a vital member of the galectin family, functioning as a multi-subtype galactose lectin with diverse biological roles. Recent research has revealed that Gal-9’s interaction with tumors is an independent factor that influences tumor ...
Minpu Zhang, Cun Liu, Ye Li, Huayao Li, Wenfeng Zhang, Jing-yao Liu, Liquan Wang, Changgang Sun   +7 more
semanticscholar   +1 more source

Antiretroviral Treatment-Induced Galectin-9 Might Impact HIV Viremia in Addition to Contributing to Inflammaging

International Journal of Molecular Sciences, 2023
Background: Galectin-9 induces HIV reactivation and also contributes to non-AIDS events through inflammaging. Hence, it is important to assess its levels in HIV-infected individuals to determine their association with HIV viremia and other comorbidities.
Ashwini Shete, Vaishnav Wagh, Jyoti Sawant, P. Shidhaye, S. Sane, A. Rao, S. Kulkarni, M. Ghate   +7 more
semanticscholar   +1 more source

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source