Results 41 to 50 of about 18,149 (205)
Impact of Galectins in Resistance to Anticancer Therapies
Clinical Cancer Research, 2020 Galectins are an endogenous family of β-galactoside-binding proteins that play complex and multifaceted roles at various stages of cancer progression, including modulation of tumor cell proliferation, signaling, adhesion, migration, invasion, epithelial ...
P. Navarro +3 more
semanticscholar +1 more source
Comparative analysis of galectin-1, galectin-3, and galectin-8 signatures in normal and choriocarcinoma trophoblast cell lines [PDF]
Archives of Biological SciencesGalectins are found in the placenta during both normal and pathological conditions. Specifically, galectins -1, -3, and -8 have been identified in extravillous trophoblast cells, with galectins -1, and -3 playing notable roles in trophoblast cell ...
Jovanović Krivokuća Milica +6 more
doaj +1 more source
Galectins in the Tumor Microenvironment: Focus on Galectin-1 [PDF]
, 2020 In the last decades, the focus of cancer research has moved from epithelial cells to the tumor milieu, in an effort to better understand tumor development and progression, and with the important end goal of translating this knowledge into effective therapies.
Martínez-Bosch, Neus +1 more
openaire +3 more sources
NAFLD‐related hepatocellular carcinoma: The growing challenge
Hepatology, EarlyView., 2022 Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah +2 more
wiley +1 more source
Hepatology, EarlyView., 2022 IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu +20 more
wiley +1 more source
Role of Galectins in Tumors and in Clinical Immunotherapy
International Journal of Molecular Sciences, 2018 Galectins are glycan-binding proteins that contain one or two carbohydrate domains and mediate multiple biological functions. By analyzing clinical tumor samples, the abnormal expression of galectins is known to be linked to the development, progression ...
Feng-Cheng Chou +3 more
semanticscholar +1 more source
Galectins and cutaneous immunity
Dermatologica Sinica, 2012 Galectins are highly expressed in epithelial cells and immune cells. In skin, they can be detected in keratinocytes, melanocytes, dendritic cells, macrophages, and T cells. Galectins are present outside and inside the cells and thus may exhibit different
Huan-Yuan Chen +4 more
doaj +1 more source
mRNA Transcriptomics of Galectins Unveils Heterogeneous Organization in Mouse and Human Brain
Frontiers in Molecular Neuroscience, 2016 Background: Galectins, a family of non-classically secreted, β-galactoside binding proteins is involved in several brain disorders; however no systematic knowledge on the normal neuroanatomical distribution and functions of galectins exits.
Sebastian John, Rashmi Mishra
doaj +1 more source
Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR) [PDF]
International Journal of Molecular Sciences, 2016 Galectins (gal) are members of the mammalian β-galactoside-binding proteins and recognize Galβ1-4GlcNAc and Galβ1-4GalNac (Thomsen-Friedenreich antigen (TF)) sequences of several cell surface oligosaccharides. In this study, gal-1, -2, -3 and -13 were investigated systematically in the trophoblast and decidua compartment of intrauterine growth ...
Stefan Hutter +7 more
openaire +3 more sources
Targeting intracellular galectins for cancer treatment
Frontiers in Immunology, 2023 Although considerable attention has been paid to the role of extracellular galectins in modulating, positively or negatively, tumor growth and metastasis, we have witnessed a growing interest in the role of intracellular galectins in response to their ...
Rita Nehmé, Yves St-Pierre
doaj +1 more source