Results 51 to 60 of about 894,458 (308)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Demonstrating the validity of the Video Game Functional Assessment-Revised (VGFA-R) [PDF]

, 2016
Problematic video play has been well documented over the course of the last decade. So much so the DSM-5 (APA, 2013) has included problematic video gaming as disorder categorized as Internet Gaming Disorder.
Frank D. Buono, Sprong, ME, Jim Bordieri, Thomas D. Upton, Upton, TD, Matthew E. Sprong, Buono, FD, Griffiths, MD, Mark D. Griffiths, Bordieri, J   +9 more
core   +1 more source

Museum game-based learning: innovative approaches from a constructivist perspective

Frontiers in Education
Constructivist learning theory emphasizes the subjectivity, sociality, and contextuality of learning, promoting learning through the creation of problem situations and guiding learners to collaborate and interact.
Hui Li, Muzhi Zhang
doaj   +1 more source

Let’s Play a Game! Kin-LDD: A Tool for Assisting in the Diagnosis of Children with Learning Difficulties

Multimodal Technologies and Interaction, 2019
This paper presents an alternative approach for the diagnosis of learning difficulties in children. A game-based evaluation study, using Kinaesthetic Learning Difficulties Diagnosis (Kin-LDD), was performed during the actual diagnosis procedure for the ...
Eleni Chatzidaki, Michalis Xenos, Charikleia Machaira   +2 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Building Community and Collaboration Applications for MMOGs

International Journal of Computer Games Technology, 2012
Supporting collaborative activities among the online players are one of the major challenges in the area of Massively Multiplayer Online Games (MMOG), since they increase the richness of gaming experience and create more engaged communities.
George Adam, Christos Bouras, Vaggelis Kapoulas, Andreas Papazois   +3 more
doaj   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

Business Process Simulation Game as a Business Process Learning Tool for Retail Companies

JIRAE (International Journal of Industrial Research and Applied Engineering), 2021
Game-based Learning has become one of the most developed learning methods in this 21st century. Game-based Learning is a good learning method because it can create a virtual world where players can simulate real-world problem-solving.
Joella Joella, Yulia Yulia, Andreas Handojo   +2 more
doaj   +1 more source