Results 71 to 80 of about 1,683,219 (290)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Editorial: Conflicts

Press Start, 2016
The Editorial Board reflects on the theme of 'conflict', as observed in the work published in this issue, and in the wider world.
Matthew Barr, Landon Kyle Berry, Mahli-Ann Butt, Daniel Joseph Dunne, Charlie Ecenbarger, Sarah Beth Evans, Lorraine Murray, Michael James Scott, Lars de Wildt   +8 more
doaj  

Игровые инстанции: авторы, акторы и реципиенты

Галактика медиа: журнал медиа исследований, 2019
В статье рассматривается приложение нарратологического теоретического аппарата (прежде всего традиции Вольфа Шмида и некоторых идей киноведческой нарратологии) к компьютерным играм.
Roman V. Voronin
doaj   +1 more source

A game based approach to improve traders' decision-making [PDF]

, 2015
Purpose: The development of a game based approach to improving the decision-making capabilities of financial traders through attention to improving the regulation of emotions during trading. Design/methodology/approach: The project used a design-based
Adam, Marc, Clough, Gill, Conole, Grainne, Fenton-O'Creevy, Mark, Gaved, Mark, Lindley, Craig, Lins, Jeffrey Todd, Peffer, Gilbert, Scanlon, Eileen, Smidts, Ale   +9 more
core  

Quantum game players can have advantage without discord

, 2015
The last two decades have witnessed a rapid development of quantum information processing, a new paradigm which studies the power and limit of "quantum advantages" in various information processing tasks.
Wei, Zhaohui, Zhang, Shengyu
core   +1 more source

Game laboratory studies

, 2015
Um die Analyse von Computerspielen aus produktionsästhetischer Perspektive zu erproben, lehnt sich der vorliegende Band an die Akteur-Netzwerk-Theorie (ANT) an. Mit ihr geht es ihm um die Frage nach den Aktanten des Game Design – etwa: Welche Hard- und Softwarekomponenten kommen wann und wofür zum Einsatz; wie und mittels welcher Medien notieren Level ...
Beil, Benjamin, Hensel, Thomas, Schröter, Jens, Bojahr, Philipp, Gläser, Tobias, Schröer, Lars, Hofmann, Gisa, Schleicher, Marlene, Brandt, Torsten, Meinrenken, Jens, Nobis, Nicolai, Urrigshardt, Frank, Förster, Julia, Reinhardt, Annika, Binay, Berk, Heidrich, Andreas, Zöller, Christian, Bienia, Rafael, Blech, Xenia, Hense, Jaro, Henkenjohann, Meike, Hofmann, Philipp, Schneider, Sarah, Petzinger, Philipp, Clüver, Claudius, Häsler, Leonie, Karidas, Alexander, Trapp, Christian, Lorber, Martin   +28 more
openaire   +2 more sources

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Sumienie graczy: podejmowanie decyzji w fabularnych grach komputerowych w kontekście socjalizacji i wrażliwości społecznej

Ars Educandi, 2013
Celem tego artykułu jest analiza potencjału gier wideo w kontekście socjalizacji oraz wrażliwości społecznej rozumianej jako świadomość tematów socjalnie marginalizowanych lub uważanych za tabu.
Piotr Prósinowski
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source