Results 11 to 20 of about 74,695 (250)
Gamma‐delta t‐cell lymphomas [PDF]
European Journal of Haematology, 2014 AbstractGamma‐delta T‐cell lymphomas are aggressive and rare diseases originating from gamma‐delta lymphocytes. These cells, which naturally play a role in the innate, non‐specific immune response, develop from thymic precursor in the bone marrow, lack the major histocompatibility complex restrictions and can be divided into two subpopulations: Vdelta1,
Foppoli M., Ferreri A. J. M.
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Gamma delta T cells in cancer therapy: from tumor recognition to novel treatments. [PDF]
Front Med (Lausanne)Luo X +9 more
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Frontiers in Immunology, 2022 The γδT cell subset of peripheral lymphocytes exhibits potent cancer antigen recognition independent of classical peptide MHC complexes, making it an attractive candidate for allogeneic cancer adoptive immunotherapy.
Gabrielle M. Ferry +7 more
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Plasticity of gamma delta T cells: impact on the anti-tumor response
Frontiers in Immunology, 2014 The tumor immune microenvironment contributes to tumor initiation, progression and response to therapy. Among the immune cell subsets that play a role in the tumor microenvironment, innate-like T cells that express T cell receptors composed of gamma and ...
Virginie eLafont +7 more
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Frontiers in Immunology, 2021 The WC1 cell surface family of molecules function as hybrid gamma delta (γδ) TCR co-receptors, augmenting cellular responses when cross-linked with the TCR, and as pattern recognition receptors, binding pathogens.
Alexandria Gillespie +7 more
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Five layers of receptor signalling in γδ T cell differentiation and activation
Frontiers in Immunology, 2015 The contributions of gamma-delta T cells to immunity to infection or tumours critically depend on their activation and differentiation into effectors capable of secreting cytokines and killing infected or transformed cells.
Sérgio T. Ribeiro +2 more
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Cutaneous gamma/delta T‐cell lymphoma [PDF]
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2009 SummaryOnly 40 cases of primary cutaneous gamma/delta T‐cell lymphoma (GD‐TCL) have been described. GD‐TCL was included as a provisional entity in the WHO‐EORTC classification of cutaneous lymphomas in 2005.GD‐TCL often failed to respond to polychemotherapy and radiation therapy and have a poor prognosis with a mean survival of only 15 months.
Richard, Koch +5 more
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Clinical applications of gamma delta T cells with multivalent immunity
Frontiers in Immunology, 2014 Gamma delta T cells hold promise for adoptive immunotherapy because of their reactivity to bacteria, viruses, and tumors. However, these cells represent a small fraction (1-5%) of the peripheral T-cell pool and require activation and propagation to ...
Drew C Deniger +2 more
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Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local
Frontiers in Immunology, 2018 Human gamma delta T cells have extraordinary properties including the capacity for tumor cell killing. The major gamma delta T cell subset in human beings is designated Vγ9Vδ2 and is activated by intermediates of isoprenoid biosynthesis or ...
C. David Pauza +6 more
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Internal Medicine, 2004 A 54-year-old woman complained of fever and hepato-splenomegaly. The pathological findings of a liver biopsy specimen revealed the infiltration of lymphocytes in the sinusoids and that of the laparoscopically resected spleen revealed the infiltration of lymphocytes in the red pulp, which was positive for CD3, CD43, CD45RO and T-cell intracellular ...
TAGUCHI, Akihiko +5 more
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