Results 41 to 50 of about 95,987 (292)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

The landscape of immune cell infiltration and its clinical implications of pancreatic ductal adenocarcinoma

Journal of Advanced Research, 2020
The details of the immunological microenvironment and its clinical implications for pancreatic cancer are still unclear. In this study, we obtained data from public databases, such as the Gene Expression Omnibus, the Cancer Genome Atlas Program, the ...
Caiming Xu, Silei Sui, Yuru Shang, Zhiyong Yu, Jian Han, Guixin Zhang, Michael Ntim, Man Hu, Peng Gong, Hailong Chen, Xianbin Zhang   +10 more
doaj   +1 more source

Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands [PDF]

, 1992
Cytomegalovirus (CMV), similar to other members of the Herpesviridae family, can establish both persistent and latent infections. Each of the CMVs that are found in many animal species replicates in the salivary gland, and oral secretion represents a ...
Pavic, Ivica, Koszinowski, Ulrich H., Koszinowski, U H, Lucin, Pero, Polic, Bojan, Jonjic, Stipan   +5 more
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Human gamma delta T regulatory cells in cancer: fact or fiction?

Frontiers in Immunology, 2014
While gamma delta T cell (γδTc) anticancer immunotherapies are being developed, recent reports suggest a regulatory role for γδTc tumor infiltrating lymphocytes (TIL).
Daniela eWesch, Christian ePeters, Gabrielle Melanie Siegers   +2 more
doaj   +1 more source

T cells expressing gamma delta chain receptors in rheumatoid arthritis.

, 1988
Whereas the majority of T cells use alpha and beta chains to form their T-cell receptor, a small minority of T cells, which do not express the CD4 or CD8 surface markers, use other chains termed gamma and delta to form their receptor.
Brenner, MB, Maini, RN, Feldmann, Marc, Londei, M, Brennan, FM, Jackson, AM, Hercend, T   +6 more
core   +1 more source

Function of gamma delta T cells in tumor immunology and their application to cancer therapy

, 2021
Cancer: T cell subset could boost immunotherapy An under-researched subset of T cells may find application in cancer immunotherapy once their multiple roles are fully understood. Jang Hyun Park and Heung Kyu Lee at the Korea Advanced Institute of Science
Lee, Heung Kyu, Park, Jang Hyun
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Gamma/delta T cells in patients with acute brucellosis

, 2009
We aimed to investigate the population of gamma/delta T (gamma/delta T) cells in patients with acute brucellosis. When the bacteria penetrate to the host, the innate immune response aims to prevent the attack by non-activated professional phagocytes.
Akbulut, H. H., Kilic, S. S., Bulut, VEDAT, Ozden, M.   +3 more
core   +1 more source

Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help. [PDF]

, 1992
Past work has shown that a subset of effector T cells with unique characteristics could abrogate hapten- or antigen-induced tolerance, and the reconstitution of this immune response has been termed contrasuppression.
J A Bluestone, Taguchi, T, J H Eldridge, Aicher, WK, K Fujihashi, T Taguchi, J R McGhee, McGhee, JR, Eldridge, JH, H Kiyono, Kiyono, H, Fujihashi, K, W K Aicher, Bluestone, JA   +13 more
core   +1 more source