Results 61 to 70 of about 74,695 (250)

EphA2 and phosphoantigen-mediated selective killing of medulloblastoma by γδT cells preserves neuronal and stem cell integrity

OncoImmunology
Medulloblastoma (MB) is a pediatric brain tumor that develops in the cerebellum, representing one of the most common malignant brain cancers in children. Standard treatments include surgery, chemotherapy, and radiation, but despite a 5-y survival rate of
Lola Boutin, Mingzhi Liu, Julie Déchanet Merville, Oscar Bedoya-Reina, Margareta T Wilhelm   +4 more
doaj   +1 more source

Engineering Approaches in Human Gamma Delta T Cells for Cancer Immunotherapy

Frontiers in Immunology, 2018
Sharing both innate and adaptive immune properties, γδT cells are attractive candidates for cellular engineering. As the cancer immunotherapy field becomes increasingly busy, orthogonal approaches are required to drive advancement.
Jonathan Fisher, John Anderson
doaj   +1 more source

Unified Pressure and Field Response Across Distinct Charge‐Order Regimes in Ti‐Doped CsV3Sb5

Advanced Functional Materials, EarlyView.
We microscopically investigate the interplay between charge order and superconductivity in a kagome superconductor across regimes of long‐ and short‐range charge order. Hydrostatic‐pressure and magnetic‐field μSR$\mu{\rm SR}$ measurements reveal remarkably similar superconducting and normal‐state time‐reversal‐symmetry‐breaking responses in both ...
P. Kral, S.S. Islam, Andrea N. Capa Salinas, J.N. Graham, O. Gerguri, A. Doll, J.A. Krieger, T.J. Hicken, G. Simutis, H. Luetkens, R. Khasanov, S.D. Wilson, Z. Guguchia   +12 more
wiley   +1 more source

Mechanistic Origins of Chemo‐Mechanical Instability and Failure in Solid‐State Lithium‐Sulfur Electrodes

Advanced Functional Materials, EarlyView.
Conversion‐induced sulfur expansion generates strong mechanical constraints and localized stresses within solid‐state Li‐S cathodes. Heterogeneous solid‐electrolyte confinement creates tensile strain‐energy hotspots that govern particle cracking. Larger sulfur particles accelerate fracture, while higher porosity relaxes constraint and delays damage ...
Arpan K. Sharma, Ahmad Ahmad, Bairav S. Vishnugopi, Partha P. Mukherjee   +3 more
wiley   +1 more source

Pan-cancer γδ TCR analysis uncovers clonotype diversity and prognostic potential

Cell Reports Medicine
Summary: Gamma-delta T cells (γδ T cells) play a crucial role in both innate and adaptive immunity within tumors, yet their presence and prognostic value in cancer remain underexplored. This study presents a large-scale analysis of γδ T cell receptor (γδ
Xiaoqing Yu, Li Song, Ling Cen, Biwei Cao, Ranran Tao, Yuanyuan Shen, Daniel Abate-Daga, Paulo C. Rodriguez, Jose R. Conejo-Garcia, Xuefeng Wang   +9 more
doaj   +1 more source

Gamma delta T cells recognize haptens and mount a hapten-specific response

eLife, 2014
The ability to recognize small organic molecules and chemical modifications of host molecules is an essential capability of the adaptive immune system, which until now was thought to be mediated mainly by B cell antigen receptors.
Xun Zeng, Christina Meyer, Jun Huang, Evan W Newell, Brian A Kidd, Yu-Ling Wei, Yueh-hsiu Chien   +6 more
doaj   +1 more source

Near‐Infrared Light‐Activated Polydopamine Nanoparticles Conjugated With Transferrin Peptides for Enhanced Brain Accumulation

Advanced Healthcare Materials, EarlyView.
This study demonstrates that Tf‐PDA NPs combine a receptor‐mediated targeting with mild photothermal activation to enhance nanoparticle accumulation in the brain. NIR‐activated Tf‐PDA NPs increase BBB permeability to NPs in vitro and in vivo without inducing cytotoxicity or adverse immune responses.
Rafaela Ferrão, Susana Simões, Paulo Rodrigues‐Santos, Vitor Francisco, Akhilesh Rai, Lino Ferreira   +5 more
wiley   +1 more source

Research progress on V delta 1+ T cells and their effect on pathogen infection [PDF]

PeerJ
The ongoing high occurrence of harmful infectious diseases significantly threatens human health. Existing methods used to control such diseases primarily involve targeting the pathogens, usually neglecting the vital role of host factors in disease ...
Yuxia Li, Yanfei Liu, Xiaoxiao Bu, Yuanyuan Qin, Yanyan Zhang   +4 more
doaj   +2 more sources

Protein‐Polymer Dynamic Hydrogels Utilizing Native Ligand Binding for Injectable Therapeutic Delivery and 3D Printing

Advanced Healthcare Materials, EarlyView.
Dynamic nanocolloidal hydrogels were synthesized via the co‐assembly of ligand‐modified spheroidal hyperbranched poly(glycerol) (HPG) and soluble albumin nanoparticles (SANs). Co‐assembly occurred through self‐association of the HPG, as well as its interaction with SANs via native ligand binding.
S. Cem Millik, Yonghui Wang, Kefan Song, Jessica M. Snyder, LeAnn Le, Lauren G. Brown, Shanny Hsuan Kuo, Ashleigh B. Theberge, Suzie H. Pun, Alshakim Nelson   +9 more
wiley   +1 more source

Limits to the Hall Effect and Other Nonreciprocal Effects in Three‐Dimensional Metamaterials

Advanced Materials, EarlyView.
Comprehensive and fundamental bounds on nonreciprocal effects in three‐dimensional metamaterials are derived. They reveal that the effective Hall mobility cannot exceed the largest constituent mobility, that, under certain conditions, the Verdet constant cannot be enhanced, and that, for constituents with Hall coefficients of the same sign, the largest
Christian Kern, Graeme W. Milton
wiley   +1 more source