Results 21 to 30 of about 182,849 (338)

A Simple and Robust Single-Step Method for CAR-Vδ1 γδT Cell Expansion and Transduction for Cancer Immunotherapy

Frontiers in Immunology, 2022
The γδT cell subset of peripheral lymphocytes exhibits potent cancer antigen recognition independent of classical peptide MHC complexes, making it an attractive candidate for allogeneic cancer adoptive immunotherapy.
Gabrielle M. Ferry, Charles Agbuduwe, Megan Forrester, Sophie Dunlop, Kerry Chester, Jonathan Fisher, John Anderson, Marta Barisa   +7 more
doaj   +1 more source

Plasticity of gamma delta T cells: impact on the anti-tumor response

Frontiers in Immunology, 2014
The tumor immune microenvironment contributes to tumor initiation, progression and response to therapy. Among the immune cell subsets that play a role in the tumor microenvironment, innate-like T cells that express T cell receptors composed of gamma and ...
Virginie eLafont, Françoise eSanchez, Emilie eLaprevotte, Henri-Alexandre eMichaud, Laurent eGros, Jean-François eEliaou, Jean-François eEliaou, Nathalie eBonnefoy   +7 more
doaj   +1 more source

Gamma Delta TCR and the WC1 Co-Receptor Interactions in Response to Leptospira Using Imaging Flow Cytometry and STORM

Frontiers in Immunology, 2021
The WC1 cell surface family of molecules function as hybrid gamma delta (γδ) TCR co-receptors, augmenting cellular responses when cross-linked with the TCR, and as pattern recognition receptors, binding pathogens.
Alexandria Gillespie, Maria Gracia Gervasi, Thillainayagam Sathiyaseelan, Timothy Connelley, Janice C. Telfer, Janice C. Telfer, Cynthia L. Baldwin, Cynthia L. Baldwin   +7 more
doaj   +1 more source

Five layers of receptor signalling in γδ T cell differentiation and activation

Frontiers in Immunology, 2015
The contributions of gamma-delta T cells to immunity to infection or tumours critically depend on their activation and differentiation into effectors capable of secreting cytokines and killing infected or transformed cells.
Sérgio T. Ribeiro, Julie C. Ribot, Bruno eSilva-Santos   +2 more
doaj   +1 more source

Gamma/Delta T Cell Lymphoma

Internal Medicine, 2004
A 54-year-old woman complained of fever and hepato-splenomegaly. The pathological findings of a liver biopsy specimen revealed the infiltration of lymphocytes in the sinusoids and that of the laparoscopically resected spleen revealed the infiltration of lymphocytes in the red pulp, which was positive for CD3, CD43, CD45RO and T-cell intracellular ...
Akihiko, Taguchi, Mutsuko, Miyazaki, Shizu, Sakuragi, Kenji, Shinohara, Toshiaki, Kamei, Yusuke, Inoue   +5 more
openaire   +3 more sources

Structural analysis of TRG1@ and TRG2@ loci of the ovine immune system

Italian Journal of Animal Science, 2011
The cellular immune system visualizes the world of pathogens largely through its T cell immune receptors (TCRs), a dimer which may be αβ or γδ.
S. Ciccarese, A. Caputi Jambrenghi, E.P. Cribiu, M. Giovinazzo, M.C. Miccoli, G. Vaccarelli   +5 more
doaj   +1 more source

The influence of zoledronate and teriparatide on gamma delta T cells in mice

Journal of Dental Sciences, 2017
Background/purpose: Few studies have investigated the possibility that bisphosphonate-related osteonecrosis of the jaw (BRONJ) might reflect an immune response; however, gamma delta T cells have been shown to significantly decline in the blood of BRONJ ...
Eiki Yamachika, Yuichi Matsui, Masakazu Matsubara, Tatsushi Matsumura, Naoki Nakata, Norifumi Moritani, Atsushi Ikeda, Hidetsugu Tsujigiwa, Naoya Ohara, Seiji Iida   +9 more
doaj   +1 more source

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients [PDF]

, 2019
Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). ROR gamma t, the key Thelperl7 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including ...
Coudenys, Julie, Cypers, Heleen, Decruy, Tine, Elewaut, Dirk, Gyselbrecht, Lieve, Harcken, Christian, Hoyt, Kathleen, Hughes, Robert, Jacques, Peggy, Labadia, Mark E., Martens, Liesbet, Mortier, Céline, Nabozny, Gerald, Piette, Yves, Saeys, Yvan, Schryvers, Nadia, Smith, Dustin, Turner, Michael, Van Calenbergh, Serge, Van den Bosch, Filip, Van Gassen, Sofie, Varkas, Gaëlle, Venken, Koen, Verheugen, Eveline, Wahle, Joseph, Wang, Chao-Ting, Wayne, Anita L., Wittoek, Ruth   +27 more
core   +3 more sources

Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours [PDF]

, 2016
Natural killer (NK) lymphocytes are part of the innate immune system and are important in immune protection against tumourigenesis. NK cells display a broad repertoire of activating and inhibitory cell surface receptors that regulate NK cell activity ...
Filtjens, Jessica, Keirsse, Jiri, Kerre, Tessa, Leclercq, Georges, Plum, Jean, Taghon, Tom, Taveirne, Sylvie, Van Acker, Aline, Van Ammel, Els, Van Ginderachter, Jo A, Vandekerckhove, Bart   +10 more
core   +2 more sources

Gamma-delta T cells in glioblastoma immunotherapy

Glioma, 2019
Conventional immunotherapy in the treatment of glioblastoma (GBM) has essentially produced no significant advantage over the use of chemotherapeutic drugs.
Sadhak Sengupta
doaj   +1 more source