Internal Medicine, 2004 A 54-year-old woman complained of fever and hepato-splenomegaly. The pathological findings of a liver biopsy specimen revealed the infiltration of lymphocytes in the sinusoids and that of the laparoscopically resected spleen revealed the infiltration of lymphocytes in the red pulp, which was positive for CD3, CD43, CD45RO and T-cell intracellular ...
Akihiko, Taguchi +5 more
openaire +3 more sources
Structural analysis of TRG1@ and TRG2@ loci of the ovine immune system
Italian Journal of Animal Science, 2011 The cellular immune system visualizes the world of pathogens largely through its T cell immune receptors (TCRs), a dimer which may be αβ or γδ.
S. Ciccarese +5 more
doaj +1 more source
The influence of zoledronate and teriparatide on gamma delta T cells in mice
Journal of Dental Sciences, 2017 Background/purpose: Few studies have investigated the possibility that bisphosphonate-related osteonecrosis of the jaw (BRONJ) might reflect an immune response; however, gamma delta T cells have been shown to significantly decline in the blood of BRONJ ...
Eiki Yamachika +9 more
doaj +1 more source
RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients [PDF]
, 2019 Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). ROR gamma t, the key Thelperl7 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including ...
Coudenys, Julie +27 more
core +3 more sources
Gamma-delta T cells in glioblastoma immunotherapy
Glioma, 2019 Conventional immunotherapy in the treatment of glioblastoma (GBM) has essentially produced no significant advantage over the use of chemotherapeutic drugs.
Sadhak Sengupta
doaj +1 more source
Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours [PDF]
, 2016 Natural killer (NK) lymphocytes are part of the innate immune system and are important in immune protection against tumourigenesis. NK cells display a broad repertoire of activating and inhibitory cell surface receptors that regulate NK cell activity ...
Filtjens, Jessica +10 more
core +2 more sources
Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis [PDF]
, 1996 The function of the minor subset of T lymphocytes bearing the gamma delta T cell antigen receptor is uncertain. Although some gamma delta T cells react to microbial products, responsiveness has only rarely been demonstrated toward a bacterial antigen ...
Alderson +48 more
core +2 more sources
Human peripheral CD4+ Vdelta1+ gamma delta T cells can develop into alpha beta T cells
Frontiers in Immunology, 2014 The lifelong generation of alpha beta T cells enables us to continuously build immunity against pathogens and malignancies despite the loss of thymic function with age. Consequently, alpha beta T-cell development has to occur independently of the thymus.
Hendrik eZiegler +6 more
doaj +1 more source
Synthesis of analogues of (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate, an isoprenoid precursor and human γδ T cell activator [PDF]
, 2008 (E)-1-Hydroxy-2-methyl-but-2-enyl 4-diphosphate (HMBPP) is an intermediate in the non-mevalonate pathway for the biosynthesis of isoprenoids and also serves as a very strong activator of human gamma delta T cells expressing V gamma 9V delta 2 receptors ...
Jomaa, Hassan +5 more
core +2 more sources
γδ T cells in HIV Disease: Past, Present and Future
Frontiers in Immunology, 2015 Human immunodeficiency virus type 1 (HIV) dysregulates γδ T cells as part of an immune evasion mechanism. Nearly 3 decades of research defined the effects of HIV on γδ T cells and how this impacts disease.
C. David ePauza +4 more
doaj +1 more source