Results 31 to 40 of about 722 (112)

Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells

Frontiers in Immunology, 2018
Epithelial and mucosal barriers are critical interfaces physically separating the body from the outside environment and are the tissues most exposed to microorganisms and potential inflammatory agents.
Camille Khairallah, Timothy H. Chu, Brian S. Sheridan   +2 more
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The Role of Gamma Delta T Cells in Autoimmune Rheumatic Diseases

Cells, 2020
Autoimmune rheumatic diseases (ARDs), affecting ~1−1.5% of all humans, are associated with considerable life long morbidity and early mortality. Early studies in the 1990s showed numerical changes of the recently discovered γδ T cells in ...
Ilan Bank
doaj   +1 more source

Significant Difference of Immune Cell Fractions and Their Correlations With Differential Expression Genes in Parkinson’s Disease

Frontiers in Aging Neuroscience, 2021
Parkinson’s disease (PD) is the second most neurodegenerative disease in the world. T cell infiltration in the central nervous system (CNS) has provided insights that the peripheral immune cells participate in the pathogenesis of PD.
Yilin Huang, Huisheng Liu, Jiaqi Hu, Chongyin Han, Zhenggang Zhong, Wei Luo, Yuhu Zhang, Fei Ling   +7 more
doaj   +1 more source

Chitosan Nanoparticles Strengthen Vγ9Vδ2 T-Cell Cytotoxicity Through Upregulation Of Killing Molecules And Cytoskeleton Polarization

International Journal of Nanomedicine, 2019
Li Lin,1,2,* Junyi He,2,* Jiawei Li,2 Yan Xu,2 Jingxia Li,2 Yangzhe Wu1,2 1Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Zhuhai Hospital Affiliated with Jinan University, Jinan University, Zhuhai, Guangdong 519000, People’s ...
Lin L, He J, Li J, Xu Y, Li J, Wu Y
doaj  

Correlation analysis between immune-related genes and cell infiltration revealed prostate cancer immunotherapy biomarkers linked to T cells gamma delta

Scientific Reports, 2023
Prostate cancer (PCa) is a urological malignancy with poor prognosis. Immune-related genes are associated with immune infiltration in prostate cancer, but their role in immunogenic PCa is less well understood.
Wenkang Niu, Tingting Zhang, Lei Ma
doaj   +1 more source

Transcriptome Signature of Vγ9Vδ2 T Cells Treated With Phosphoantigens and Notch Inhibitor Reveals Interplay Between TCR and Notch Signaling Pathways

Frontiers in Immunology, 2021
Gamma delta (γδ) T cells, especially the Vγ9Vδ2 subtype, have been implicated in cancer therapy and thus have earned the spotlight in the past decade.
Ayush Madhok, Sajad Ahmad Bhat, Sajad Ahmad Bhat, Chinna Susan Philip, Chinna Susan Philip, Shalini Kashipathi Sureshbabu, Shalini Kashipathi Sureshbabu, Shubhada Chiplunkar, Shubhada Chiplunkar, Sanjeev Galande, Sanjeev Galande   +10 more
doaj   +1 more source

SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire

eLife
During thymic development, most γδ T cells acquire innate-like characteristics that are critical for their function in tumor surveillance, infectious disease, and tissue repair.
Somen K Mistri, Brianna M Hilton, Katherine J Horrigan, Emma S Andretta, Remi Savard, Oliver Dienz, Kenneth J Hampel, Diana L Gerrard, Joshua T Rose, Nikoletta Sidiropoulos, Dev Majumdar, Jonathan E Boyson   +11 more
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Three-Dimensional Modeling of Camelus dromedarius T Cell Receptor Gamma (TRG)_Delta (TRD)/CD1D Complex Reveals Different Binding Interactions Depending on the TRD CDR3 Length

Antibodies
Background: In the adaptive immune response of the dromedary (Camelus dromedarius, Camdro), the T cell receptor (TR) repertoire of the gamma–delta (γδ) T cells is unusually diversified both by somatic hypermutation in rearranged TR gamma (TRG) and delta (
Salvatrice Ciccarese, Marie-Paule Lefranc, Giulia C. M. Perrone, Pietro D’Addabbo, Ciro Leonardo Pierri   +4 more
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EphA2 and phosphoantigen-mediated selective killing of medulloblastoma by γδT cells preserves neuronal and stem cell integrity

OncoImmunology
Medulloblastoma (MB) is a pediatric brain tumor that develops in the cerebellum, representing one of the most common malignant brain cancers in children. Standard treatments include surgery, chemotherapy, and radiation, but despite a 5-y survival rate of
Lola Boutin, Mingzhi Liu, Julie Déchanet Merville, Oscar Bedoya-Reina, Margareta T Wilhelm   +4 more
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Engineering Approaches in Human Gamma Delta T Cells for Cancer Immunotherapy

Frontiers in Immunology, 2018
Sharing both innate and adaptive immune properties, γδT cells are attractive candidates for cellular engineering. As the cancer immunotherapy field becomes increasingly busy, orthogonal approaches are required to drive advancement.
Jonathan Fisher, John Anderson
doaj   +1 more source