Results 31 to 40 of about 180,882 (293)

Non-V delta 2 gamma delta T lymphocytes as effectors of cancer immunotherapy [PDF]

, 2014
Gamma delta T cells (γδT) are potent mediators of antitumor cytotoxicity and have shown promising efficacy in early phase clinical trials. Most is known about the tumoricidal properties of cells bearing the Vδ2 T cell receptor chain, but recent studies ...
Anderson, J, Fisher, J, Gustafsson, K, Kramer, AM   +3 more
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Sheep TRD@ locus consists of a large number of TRDV elements

Italian Journal of Animal Science, 2011
The T cell receptor (TcR) expressed on mature T lymphocytes is a disulphidelinked heterodimer composed of alpha and beta or gamma and delta glycoprotein subunits.
S. Ciccarese, S. Massari, G. Vonghia, A. Caputi Jambrenghi, D. Pagliarulo, R. Antonacci, L. Del Faro   +6 more
doaj   +1 more source

Climate change, in the framework of the constructal law [PDF]

, 2011
Here we present a simple and transparent alternative to the complex models of Earth thermal behavior under time-changing conditions. We show the one-to-one relationship between changes in atmospheric properties and time-dependent changes in temperature ...
Alberton, Bruna, Almeida, Jurandy, Miranda, Waner O., Morellato, Leonor Patricia C., Santos, Jefersson A. dos, Torres, Ricardo da S.   +5 more
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Mycobacterium tuberculosis promotes Th17 expansion via regulation of human dendritic cells toward a high CD14 and low IL-12p70 phenotype that reprograms upon exogenous IFN-γ. [PDF]

, 2014
Item does not contain fulltextThe capacity to develop protective immunity against mycobacteria is heterogeneously distributed among human beings, and it is currently unknown why the initial immune response induced against Mycobacterium tuberculosis (Mtb)
Acosta-Rodriguez, Agrawal, Bakdash, Bazil, Bazil, Bratke, Chackerian, Chen, Cheong, Chu, Cohn, Demedts, Desjardins, Evans, Fujii, Gautier, Geijtenbeek, Gerosa, Giacomini, Harding, Henderson, Hoene, Hsieh, Ishikawa, Iwasaki, Janne Marie Laursen, Jiao, Jonas Nørskov Søndergaard, Jung, Lai, Lauener, Lisbeth Buus Rosholm, Lucas, Martin, Nathan, Nathan, Nestle, Nigou, Ní Cheallaigh, Owaki, Ramakrishnan, Redford, Russell, Sallusto, Schreiber, Serbina, Susanne Brix, Søndergaard, Tailleux, Tailleux, Torrado, Trinchieri, Uehori, Underhill, Van der Aar, Van Haarst, van Haarst, Varol, Wilson, Winslow, Wolf, World Health Organization, Zanoni, Zenaro   +63 more
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Hepatosplenic Gamma/DeltaT-Cell Lymphoma Masquerading as Alcoholic Hepatitis and Methadone Withdrawal

Case Reports in Gastroenterology, 2007
Hepatosplenic gamma/delta T-cell lymphoma is a rare neoplasm of mature gamma/delta T-cells with sinusoidal infiltration of spleen, liver, and bone marrow.
H.A. Lopez Morra, S.N. Fine, G. Dickstein   +2 more
doaj   +1 more source

Pig peripheral blood mononuclear leucocyte subsets are heritable and genetically correlated with performance [PDF]

, 2008
Indicator traits used to select pigs for increased resistance to infection or improved health must be heritable and, preferably, be associated with improved performance.
Ahmadi, Cheeseman, Chen, Clapperton, Clapperton, Clapperton, Davis, de Haan, Denham, Denyer, Duarte, E.J. Glass, Edfors-Lilja, Edfors-Lilja, Eurell, Evans, Galina-Pantoja, Gheorgiou, Gilmour, Grellner, Hall, Hall, Haverson, Henryon, Henryon, Jayagopala Reddy, Joling, Lee, Lodoen, Loeffen, Luhtala, Lyons, M. Clapperton, Mallard, Morrison, Myrick, Ober, O’Connor, Pallarés, Parra, Pedrini, Petersen, Poppe, Regula, Roberts, S.C. Bishop, Saalmuller, Segalés, Snowder, Spurlock, Tecles, Thacker, Wonigeit, Yang, Zuckermann   +54 more
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Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer

Nature Communications, 2021
Gamma delta (γδ) T cells have potential for use in immunotherapy against tumours. Here, the authors demonstrate that treatment of tumours with DNA methyltransferase inhibitors modulates cytoskeleton arrangements, upregulates adhesion molecules and ...
Rueyhung R. Weng, Hsuan-Hsuan Lu, Chien-Ting Lin, Chia-Chi Fan, Rong-Shan Lin, Tai-Chung Huang, Shu-Yung Lin, Yi-Jhen Huang, Yi-Hsiu Juan, Yi-Chieh Wu, Zheng-Ci Hung, Chi Liu, Xuan-Hui Lin, Wan-Chen Hsieh, Tzu-Yuan Chiu, Jung-Chi Liao, Yen-Ling Chiu, Shih-Yu Chen, Chong-Jen Yu, Hsing-Chen Tsai   +19 more
doaj   +1 more source

Chemotherapy accelerates immune-senescence and functional impairments of Vδ2pos T cells in elderly patients affected by liver metastatic colorectal cancer. [PDF]

, 2019
Human (gamma delta) γδ T cells are unconventional innate-like lymphocytes displaying a broad array of anti-tumor activities with promising perspectives in cancer immunotherapy.
Bruni E, Cazzetta V, Cimino M, Dieli F, Donadon M, Leonardi G, Mavilio D., Mikulak J, Spata G, Torzilli G   +9 more
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Multiple receptor-ligand interactions direct tissue resident gamma delta T cell activation

Frontiers in Immunology, 2014
Gamma delta T cells represent a major T cell population in epithelial tissues, such as skin, intestine, and lung, where they function in maintenance of the epithelium and provide a crucial first line defense against environmental and pathogenic insults.
Deborah A. Witherden, Kevin eRamirez, Wendy L. Havran   +2 more
doaj   +1 more source

In vitro-differentiated T/natural killer-cell progenitors derived from human CD34+ cells mature in the thymus [PDF]

, 2010
Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is a treatment option for patients with hematopoietic malignancies that is hampered by treatment-related morbidity and mortality, in part the result of opportunistic infections, a direct
Borsotti, C, Bos, G M, Cloosen, S, Germeraad, W T, Hesselink, R, Katsura, Y, Kawamoto, H, Leewis, B, Manz, M G, Meek, B, Schnijderberg, M C, van der Poel, M W, Van Elssen, C H, Vanderlocht, J   +13 more
core   +1 more source