Results 51 to 60 of about 180,882 (293)

Gamma delta (γδ) T cells: origin, phenotype, functions

Медицинская иммунология
The primary function of γδT cells is to regulate the responses of innate and adaptive immune systems. These cells also play a role in antibacterial, antiviral and antitumor immune responses, regulate inflammation, maintain homeostasis in barrier tissues,
D. I. Sokolov
doaj   +1 more source

Predominant variable region gene usage by gamma/delta T cell receptor-bearing cells in the adult thymus. [PDF]

, 1988
Previous studies have indicated that the diversity of gamma genes expressed by gamma/delta-bearing murine T cells is limited, but comparable information concerning the expressed diversity of delta genes is lacking. In this study, we have investigated the
Korman, A, Kruisbeek, A, Marusic-Galesic, S, RAULET, David H., Spencer, D   +4 more
core  

Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure. [PDF]

, 2017
Vδ2+ γδ T cells are semi-innate T cells that expand markedly following P. falciparum (Pf) infection in naïve adults, but are lost and become dysfunctional among children repeatedly exposed to malaria.
Bowen, Katherine, Boyle, Michelle J, Budker, Rachel, Dorsey, Grant, Farrington, Lila A, Feeney, Margaret E, Greenhouse, Bryan, Jagannathan, Prasanna, Kamya, Moses R, Katureebe, Agaba, Lutwama, Fredrick, McIntyre, Tara I, Musinguzi, Kenneth, Nalubega, Mayimuna, Naluwu, Kate, Nankya, Felistas, Rek, John, Sikyomu, Esther   +17 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Human gamma delta T regulatory cells in cancer: fact or fiction?

Frontiers in Immunology, 2014
While gamma delta T cell (γδTc) anticancer immunotherapies are being developed, recent reports suggest a regulatory role for γδTc tumor infiltrating lymphocytes (TIL).
Daniela eWesch, Christian ePeters, Gabrielle Melanie Siegers   +2 more
doaj   +1 more source

Defective development of gamma/delta T cells in interleukin 7 receptor-deficient mice is due to impaired expression of T cell receptor gamma genes. [PDF]

, 1999
Mice lacking the interleukin 7 receptor (IL-7R) generate alpha/beta T cells at a detectable but greatly reduced rate, but gamma/delta T cells are completely absent.
Coles, M, Kang, J, RAULET, David H.
core   +1 more source

Single and cross-generation natural hedging of longevity and financial risk [PDF]

, 2012
The paper provides natural hedging strategies among death benefits and annuities written on a single and on different generations. It obtains closed-form Delta and Gamma hedges, in the presence of both longevity and interest rate risk.
Luciano, Elisa, Regis, Luca, Vigna, Elena   +2 more
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The Role of Gamma Delta T Cells in Autoimmune Rheumatic Diseases

Cells, 2020
Autoimmune rheumatic diseases (ARDs), affecting ~1−1.5% of all humans, are associated with considerable life long morbidity and early mortality. Early studies in the 1990s showed numerical changes of the recently discovered γδ T cells in ...
Ilan Bank
doaj   +1 more source

Significant Difference of Immune Cell Fractions and Their Correlations With Differential Expression Genes in Parkinson’s Disease

Frontiers in Aging Neuroscience, 2021
Parkinson’s disease (PD) is the second most neurodegenerative disease in the world. T cell infiltration in the central nervous system (CNS) has provided insights that the peripheral immune cells participate in the pathogenesis of PD.
Yilin Huang, Huisheng Liu, Jiaqi Hu, Chongyin Han, Zhenggang Zhong, Wei Luo, Yuhu Zhang, Fei Ling   +7 more
doaj   +1 more source