Results 41 to 50 of about 722 (112)

Pan-cancer γδ TCR analysis uncovers clonotype diversity and prognostic potential

Cell Reports Medicine
Summary: Gamma-delta T cells (γδ T cells) play a crucial role in both innate and adaptive immunity within tumors, yet their presence and prognostic value in cancer remain underexplored. This study presents a large-scale analysis of γδ T cell receptor (γδ
Xiaoqing Yu, Li Song, Ling Cen, Biwei Cao, Ranran Tao, Yuanyuan Shen, Daniel Abate-Daga, Paulo C. Rodriguez, Jose R. Conejo-Garcia, Xuefeng Wang   +9 more
doaj   +1 more source

Gamma delta T cells recognize haptens and mount a hapten-specific response

eLife, 2014
The ability to recognize small organic molecules and chemical modifications of host molecules is an essential capability of the adaptive immune system, which until now was thought to be mediated mainly by B cell antigen receptors.
Xun Zeng, Christina Meyer, Jun Huang, Evan W Newell, Brian A Kidd, Yu-Ling Wei, Yueh-hsiu Chien   +6 more
doaj   +1 more source

Research progress on V delta 1+ T cells and their effect on pathogen infection [PDF]

PeerJ
The ongoing high occurrence of harmful infectious diseases significantly threatens human health. Existing methods used to control such diseases primarily involve targeting the pathogens, usually neglecting the vital role of host factors in disease ...
Yuxia Li, Yanfei Liu, Xiaoxiao Bu, Yuanyuan Qin, Yanyan Zhang   +4 more
doaj   +2 more sources

Gamma delta T-lymphocytes in hepatitis C and chronic liver disease

Frontiers in Immunology, 2014
Discovered thirty years ago, gamma delta (γδ) T-lymphocytes remain an intriguing and enigmatic T-cell subset. Although in humans they comprise a small fraction of the total circulating T-lymphocyte pool, they represent an important T-cell subset in ...
neil erajoriya, neil erajoriya, Joannah Ruth Fergusson, Jo eLeithead, Paul eKlenerman   +4 more
doaj   +1 more source

Gamma Delta (γδ) T Cells and Their Involvement in Behçet’s Disease

Journal of Immunology Research, 2015
Behçet’s disease (BD) is a multisystem inflammatory disorder characterized by orogenital ulcerations, ocular manifestations, arthritis, and vasculitis. The disease follows a relapsing-remitting course and its pathogenesis is unknown.
Md. Samiul Hasan, Lesley Ann Bergmeier, Harry Petrushkin, Farida Fortune   +3 more
doaj   +1 more source

High Interferon-γ Uniquely in Vδ1 T Cells Correlates with Markers of Inflammation and Axonal Damage in Early Multiple Sclerosis

Frontiers in Immunology, 2017
We have identified a population of T lymphocytes in peripheral blood, Vδ1 TCRγδ T lymphocytes, which unexpectedly was uniquely expressing high production of interferon-γ in newly diagnosed, untreated multiple sclerosis (MS) patients.
Avadhesh Kumar Singh, Lenka Novakova, Markus Axelsson, Clas Malmeström, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Jan Lycke, Susanna L. Cardell   +8 more
doaj   +1 more source

T10B9 monoclonal antibody: A short-acting nonstimulating monoclonal antibody that spares γδ T-cells and treats and prevents cellular rejection

Drug Design, Development and Therapy, 2009
Thomas H Waid1, John S Thompson1, Maria Siemionow2, Stephen A Brown1 1Department of Internal Medicine, University of Kentucky, Lexington, Kentucky, USA; 2Cleveland Clinic, Cleveland, Ohio, USAAbstract: T10B9.1A-31/MEDI-500 is a ...
Thomas H Waid, John S Thompson, Maria Siemionow, Stephen A Brown   +3 more
doaj  

Role of innate T cells in anti-bacterial immunity

Frontiers in Immunology, 2015
Innate T cells are a heterogeneous group of αβ and γδ T cells that respond rapidly (
Yifang eGao, Anthony P Williams, Anthony P Williams   +2 more
doaj   +1 more source

Gamma delta T cells and their immunotherapeutic potential in cancer

Biomarker Research
Gamma–delta (γδ) T cells are a unique subset of T lymphocytes that play diverse roles in immune responses, bridging innate and adaptive immunity. With growing interest in their potential for cancer immunotherapy, a comprehensive and inclusive exploration
Stephen G. Cieslak, Reza Shahbazi
doaj   +1 more source

The emerging roles of gamma-delta T cells in tissue inflammation in experimental autoimmune encephalomyelitis

Frontiers in Immunology, 2016
γδ (gamma delta) T cells, a small population of unconventional T cells, have been seen in central nervous system (CNS) lesions of multiple sclerosis (MS) patients, but their function in disease activity is not clearly understood.
Amit eAwasthi, Sakshi eMalik, Muzamil Yaqub Want   +2 more
doaj   +1 more source