A combination of proviral and antiviral roles of CD11c- and T-bet-expressing B cells defines parameters of chronic murine gammaherpesvirus infection [PDF]
mBioGammaherpesviruses are ubiquitous pathogens that establish lifelong infection and are associated with the development of cancer and multiple sclerosis.
Erika R. Johansen +5 more
doaj +2 more sources
B cell-intrinsic IRF-1 and conserved gammaherpesvirus protein kinase cooperate to promote murine gammaherpesvirus-driven germinal center response and splenic latent reservoir [PDF]
Journal of VirologyGammaherpesviruses infect >90% of adults and are associated with B cell lymphomas. These viruses drive the expansion and differentiation of germinal center B cells to amplify latent viral reservoir and ensure life-long infection of memory B cells ...
Cade R. Rahlf +3 more
doaj +2 more sources
B cell-intrinsic interleukin 17 receptor A signaling supports the establishment of chronic murine gammaherpesvirus 68 infection [PDF]
Journal of VirologyThe human-specific gammaherpesviruses Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus infect >95% of all adults, establish lifelong infections, and are associated with multiple different cancers, including B-cell lymphomas.
Sheikh Tahir Majeed +3 more
doaj +2 more sources
Gammaherpesvirus infection unveils exaggerated germinal center responses in an SR-BI-deficient host [PDF]
Journal of VirologyLipid metabolism has emerged as an important regulator of acute viral infections by affecting viral replication and the host immune response. In contrast, the role of host lipid metabolism during chronic viral infection has been less explored.
Damon L. Schmalzriedt +6 more
doaj +2 more sources
Guinea Pig X Virus Is a Gammaherpesvirus [PDF]
VirusesThe Guinea Pig X Virus (GPXV), a newly identified gammaherpesvirus, provides an opportunity to study viral evolution and host–virus dynamics. This study characterizes the GPXV genome and investigates its phylogenetic relationships and divergence from ...
Vy Ngoc Yen Truong +2 more
doaj +2 more sources
Apolipoprotein E selectively supports gammaherpesvirus replication in macrophages [PDF]
Journal of VirologyGammaherpesviruses establish lifelong infections in over 90% of adults worldwide and contribute to the development of several cancers. Endogenous lipid synthesis pathways support lytic and latent life cycles of several gammaherpesviruses.
Damon L. Schmalzriedt +8 more
doaj +2 more sources
Combination of proviral and antiviral roles of B cell-intrinsic STAT1 expression defines parameters of chronic gammaherpesvirus infection [PDF]
mBioGammaherpesviruses are species-specific, ubiquitous pathogens that establish lifelong infection in their hosts and are associated with cancers, including B cell lymphomas. Type I and II interferons (IFNs) are critical for the control of acute and chronic
Erika R. Johansen +8 more
doaj +2 more sources
Long-read transcriptomics of caviid gammaherpesvirus 1: compiling a comprehensive RNA atlas [PDF]
mSystemsCaviid gammaherpesvirus 1 (CaGHV-1), formerly known as the guinea pig herpes-like virus, is an oncogenic gammaherpesvirus with a sequenced genome but an as-yet uncharacterized transcriptome. Using nanopore long-read RNA sequencing, we annotated the CaGHV-
Gábor Torma +8 more
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The innate and T-cell mediated immune response during acute and chronic gammaherpesvirus infection
Frontiers in Cellular and Infection Microbiology, 2023 Immediately after entry into host cells, viruses are sensed by the innate immune system, leading to the activation of innate antiviral effector mechanisms including the type I interferon (IFN) response and natural killer (NK) cells.
Viktoria Rex +7 more
doaj +1 more source
E3 Ubiquitin Ligases in Gammaherpesviruses and HIV: A Review of Virus Adaptation and Exploitation
Viruses, 2023 For productive infection and replication to occur, viruses must control cellular machinery and counteract restriction factors and antiviral proteins.
Jessica Oswald +5 more
doaj +1 more source