A Gammaherpesvirus Ubiquitin-Specific Protease Is Involved in the Establishment of Murine Gammaherpesvirus 68 Infection [PDF]
Journal of Virology, 2009 ABSTRACT Murine gammaherpesvirus 68 (MHV-68) contains a ubiquitin (Ub)-specific cysteine protease (USP) domain embedded within the large tegument protein ORF64, as do all other herpesviruses. The biological role of this protease is still unclear, but for the alphaherpesvirus Marek's disease virus, its USP is involved in T-cell lymphoma ...
Sara, Gredmark-Russ +5 more
openaire +2 more sources
mBio, 2019 Gammaherpesviruses, including the human pathogens Epstein-Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV), directly contribute to the genesis of multiple types of malignancies, including B cell lymphomas. In vivo, these viruses infect
Yiping Wang +3 more
doaj +1 more source
Dangerous Liaisons: Gammaherpesvirus Subversion of the Immunoglobulin Repertoire
Viruses, 2020 A common biologic property of the gammaherpesviruses Epstein–Barr Virus and Kaposi sarcoma herpesvirus is their use of B lymphocytes as a reservoir of latency in healthy individuals that can undergo oncogenic transformation later in life ...
Monika A. Zelazowska +2 more
doaj +1 more source
Characterization of omental immune aggregates during establishment of a latent gammaherpesvirus infection. [PDF]
PLoS ONE, 2012 Herpesviruses are characterized by their ability to establish lifelong latent infection. The gammaherpesvirus subfamily is distinguished by lymphotropism, establishing and maintaining latent infection predominantly in B lymphocytes.
Kathleen S Gray +2 more
doaj +1 more source
Identification of Alternative Transcripts Encoding the Essential Murine Gammaherpesvirus Lytic Transactivator RTA [PDF]
, 2014 The essential immediate early transcriptional activator RTA, encoded by gene 50, is conserved among all characterized gammaherpesviruses. Analyses of a recombinant murine gammaherpesvirus 68 (MHV68) lacking both of the known gene 50 promoters (G50DblKo ...
Gray, Kathleen S +5 more
core +2 more sources
Antiviral activity of 20(R)-ginsenoside Rh2 against murine gammaherpesvirus
Journal of Ginseng Research, 2017 Background: Ginsenosides are the major components of Panax ginseng Meyer, an herbal medicine used for the treatment of various diseases. Different ginsenosides contribute to the biological properties of ginseng, such as antimicrobial, anticancer, and ...
Soowon Kang +3 more
doaj +1 more source
Stabilization of Myc through Heterotypic Poly-Ubiquitination by mLANA Is Critical for γ-Herpesvirus Lymphoproliferation [PDF]
, 2013 Host colonization by lymphotropic γ-herpesviruses depends critically on expansion of viral genomes in germinal center (GC) B-cells. Myc is essential for the formation and maintenance of GCs.
Kaye, Kenneth M. +3 more
core +3 more sources
Type 1 interferons and NK cells restrict gamma-herpesvirus lymph node infection [PDF]
, 2016 Gamma-herpesviruses establish persistent, systemic infections and cause cancers. Murid Herpesvirus-4 (MuHV-4) provides a unique window onto the early events of host colonization. It spreads via lymph nodes. While dendritic cells (DC) pass MuHV-4 to lymph
Lawler, Clara +3 more
core +1 more source
Oropharyngeal Shedding of Gammaherpesvirus DNA by Cats, and Natural Infection of Salivary Epithelium
Viruses, 2022 Felis catus gammaherpesvirus-1 (FcaGHV1), a novel candidate oncogenic virus, infects cats worldwide. Whether the oropharynx is a site of virus shedding and persistence, and whether oronasal carcinomas harbor FcaGHV1 nucleic acid were investigated.
Elizabeth C. Rose +9 more
doaj +1 more source
First molecular determination of herpesvirus from two mysticete species stranded in the Mediterranean Sea [PDF]
, 2015 BACKGROUND Herpesvirus can infect a wide range of animal species: mammals, birds, reptiles, fish, amphibians and bivalves. In marine mammals, several alpha- and gammaherpesvirus have been identified in some cetaceans and pinnipeds species.
Crespo Picazo, José Luis +4 more
core +2 more sources