Results 71 to 80 of about 10,381 (200)

Herpesvirus genome integration in whole‐genome sequences of dementia and control cohorts

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION The infectious hypothesis suggests that microbes like herpesviruses may play a role in the pathogenesis of Alzheimer's disease (AD) and other related dementias through methods that may include viral genome integration. The occurrence of herpesvirus genome integration in dementia patients has not been thoroughly characterized ...
Stacey L. Piotrowski, Mary Alice Allnutt, Kory Johnson, Toshiko Tanaka, Luigi Ferrucci, Huw Morris, John Hardy, PROSPECT Consortium, Mina Ryten, United Kingdom Brain Expression Consortium (UKBEC), Giancarlo Logroscino, Juan Troncoso, Thomas G. Beach, Geidy E. Serrano, Carlos Cruchaga, Dennis W. Dickson, Owen A. Ross, Adriano Chiò, International LBD Genomics Consortium, International ALS Genomics Consortium, Henry Houlden, The American Genome Center, Clifton L. Dalgard, Jinhui Ding, J. Raphael Gibbs, Bryan J. Traynor, Sonja W. Scholz, Steven Jacobson   +27 more
wiley   +1 more source

Alteration of the Premature tRNA Landscape by Gammaherpesvirus Infection

mBio, 2020
Transfer RNAs (tRNAs) are transcribed by RNA polymerase III (RNAPIII) and play a central role in decoding our genome, yet their expression and noncanonical function remain understudied.
Jessica M. Tucker, Aaron M. Schaller, Ian Willis, Britt A. Glaunsinger   +3 more
doaj   +1 more source

Analysis of a Novel Strain of Murine Gammaherpesvirus Reveals a Genomic Locus Important for Acute Pathogenesis [PDF]

, 2001
Infection of mice by murine gammaherpesvirus 68 (MHV-68) is an excellent small-animal model of gammaherpesvirus pathogenesis in a natural host. We have carried out comparative studies of another herpesvirus, murine herpesvirus 76 (MHV-76), which was ...
Allen, D. J., Brownstein, D. G., Davison, A. J., Dutia, B. M., Macrae, A. I., Milligan, S., Mistrikova, J., Nash, A. A., Stewart, James P.   +8 more
core   +1 more source

Inhibition of Gammaherpesvirus Replication by RNA Interference [PDF]

Journal of Virology, 2003
ABSTRACT RNA interference (RNAi) is a conserved mechanism in which double-stranded, small interfering RNAs (siRNAs) trigger a sequence-specific gene-silencing process. Here we describe the inhibition of murine herpesvirus 68 replication by siRNAs targeted to sequences encoding Rta, an immediate-early protein known as an initiator of the lytic
Qingmei, Jia, Ren, Sun
openaire   +2 more sources

DESIGN AND GENERATION OF A RECOMBINANT GAMMAHERPESVIRUS ENCODING shRNA FROM A NATIVE VIRAL tRNA PROMOTER

Trakya University Journal of Natural Sciences, 2023
Gammaherpesviruses are associated with multiple types of tumor development and understanding the pathogenesis of these viruses has been the subject of various studies.
Scott Tibbetts, Mehmet Kara
doaj   +1 more source

Virus‐Dependent Geographic Structure of Co‐Circulating Viruses in a Single Bat Species

Molecular Ecology, Volume 35, Issue 5, March 2026.
ABSTRACT Understanding the spatial spread of viruses within wildlife populations is often a key component of disease management efforts. Viral spread is likely constrained by host ecology, but inter‐virus differences in infection strategy might allow some viruses to overcome these constraints, leading to divergent population structures within a common ...
Avery L. Holmes, Alice Broos, Daniel J. Becker, Jorge E. Carrera, Maxwell J. Farrell, Rita Ribeiro, Carlos Tello, Laura M. Bergner, Daniel G. Streicker   +8 more
wiley   +1 more source

Characterization of Gammaherpesvirus 68 Gene 50 Transcription [PDF]

Journal of Virology, 2000
ABSTRACT Gene 50 is the only immediate-early gene that appears to be conserved among the characterized gammaherpesviruses. It has recently been demonstrated for the human viruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) that ectopic expression of the gene 50-encoded product in some latently infected cell ...
S, Liu, I V, Pavlova, H W, Virgin, S H, Speck   +3 more
openaire   +2 more sources

An RS Motif within the Epstein-Barr Virus BLRF2 Tegument Protein Is Phosphorylated by SRPK2 and Is Important for Viral Replication [PDF]

, 2013
Epstein-Barr virus (EBV) is a gammaherpesvirus that causes infectious mononucleosis, B cell lymphomas, and nasopharyngeal carcinoma. Many of the genes required for EBV virion morphogenesis are found in all herpesviruses, but some are specific to ...
Adelmant, Guillaume, Calderwood, Michael A, Deng, Hongyu, Duarte, Melissa, Hill, David E., Johannsen, Eric, Marto, Jarrod, Ohashi, Makoto, Roecklein-Canfield, Jennifer, Wang, Lili   +9 more
core   +10 more sources

Isolation and Characterization of a Novel Gammaherpesvirus from a Microbat Cell Line

mSphere, 2016
While employing deep sequencing and de novo assembly to characterize the mRNA transcript profile of a cell line derived from the microbat Myotis velifer incautus, we serendipitously identified mRNAs encoding proteins with a high level of identity to ...
Reed S. Shabman, Susmita Shrivastava, Tshidi Tsibane, Oliver Attie, Anitha Jayaprakash, Chad E. Mire, Kari E. Dilley, Vinita Puri, Timothy B. Stockwell, Thomas W. Geisbert, Ravi Sachidanandam, Christopher F. Basler   +11 more
doaj   +1 more source

Protective vaccination with hepatitis C virus NS3 but not core antigen in a novel mouse challenge model [PDF]

, 2008
BACKGROUND: Efficient vaccines against hepatitis C virus (HCV) infection are urgently needed. Vaccine development has been hampered by the lack of suitable small animal models to reliably test the protective capacity of immmunization. METHODS: We used
Adler, Adler, Arribillaga, Battegay, Bergqvist, Bruna-Romero, Cerny, Diepolder, Diepolder, Eisen-Vandervelde, El-Gogo, Fischer, Flano, Flano, Folgori, Frelin, Geissler, Gerlach, Gonzalez-Aseguinolaza, Grakoui, Gruener, Houghton, Inchauspe, Kato, Kittlesen, Large, Major, Marques, McLauchlan, Messerle, Nascimbeni, Nash, Rollier, Schirren, Shirai, Shoukry, Staib, Staib, Staib, Staib, Stevenson, Stewart, Sunil-Chandra, Takaki, Thimme, Ulsenheimer, Usherwood, Virgin, Virgin, Weck, Willer, Yao   +51 more
core   +1 more source