Results 81 to 90 of about 10,381 (200)
The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection. [PDF]
, 2015 Journal ArticleTGFβ-ALK5 pro-fibrotic signalling and herpesvirus infections have been implicated in the pathogenesis and exacerbation of pulmonary fibrosis. In this study we addressed the role of TGFβ-ALK5 signalling during the progression of fibrosis in
Alexander, RE +8 more
core +2 more sources
Latent, Lytic, and Linked to Multiple Sclerosis—How EBV Drives Autoimmunity
European Journal of Immunology, Volume 56, Issue 2, February 2026.EBV latent and lytic genes uniquely contribute to Multiple Sclerosis development by various immunopathogenic mechanisms in susceptible hosts. Briefly, EBV infection shapes the B‐cell repertoire and promotes the oligoclonal expansion and subsequent CNS infiltration of T‐bet+CXCR3+ B cells, resulting in a cascade of immune dysregulation, CNS inflammation,
Fabienne Läderach +2 more
wiley +1 more source
Ablation of STAT3 in the B Cell Compartment Restricts Gammaherpesvirus Latency
mBio, 2016 A challenging property of gammaherpesviruses is their ability to establish lifelong persistence. The establishment of latency in B cells is thought to involve active virus engagement of host signaling pathways.
Sandeep Steven Reddy +6 more
doaj +1 more source
Vaccines, 2021 An efficacious vaccine for sheep-associated malignant catarrhal fever (SA-MCF) is important for the livestock industry. Research towards SA-MCF vaccine development is hindered by the absence of culture systems to propagate the causative agent, ovine ...
Smriti Shringi +7 more
doaj +1 more source
Closing the gap on causal processes of infection risk from cross-sectional data:structural equation models to understand infection and co-infection [PDF]
, 2015 BACKGROUND: Epidemiological studies of disease exposure risk are frequently based on observational, cross-sectional data, and use statistical approaches as crucial tools for formalising causal processes and making predictions of exposure risks.
Barrs, Vanessa R. +9 more
core +3 more sources
Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.Pulmonary infections remain a significant global health burden, particularly in immunocompromised individuals and patients with chronic respiratory or systemic diseases. Conventional microbiological tests (CMTs), though widely used, often have limited sensitivity and delayed results, especially in polymicrobial or atypical infections.
Ying Zhao +7 more
wiley +1 more source
Viruses, 2022 Human respiratory syncytial virus (hRSV) infection brings a wide spectrum of clinical outcomes, from a mild cold to severe bronchiolitis or even acute interstitial pneumonia. Among the known factors influencing this clinical diversity, genetic background
Gautier Gilliaux, Daniel Desmecht
doaj +1 more source
Rodent herpesvirus Peru encodes a secreted chemokine decoy receptor [PDF]
, 2013 Viruses have long been studied not only for their pathology and associated disease but also as model systems for understanding cellular and immunological processes. Rodent herpesvirus Peru (RHVP) is a recently characterized rhadinovirus related to murine
Alcami +58 more
core +2 more sources
Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.Reports of brucellosis in free‐ranging cetaceans are increasing worldwide, particularly in the Mediterranean Sea. To enhance diagnostic accuracy and epidemiological understanding of cetacean brucellosis in the Western Mediterranean Sea, we analyzed bacteriological, serological, and molecular data from 30 cetaceans belonging to three different species ...
Ignacio Vargas-Castro +15 more
wiley +1 more source
Virus-Encoded MicroRNAs Facilitate Gammaherpesvirus Latency and Pathogenesis
mBio, 2014 Gammaherpesviruses, including Epstein-Barr virus (EBV), Kaposi sarcoma-associated herpesvirus (KSHV, or HHV-8), and murine gammaherpesvirus 68 (MHV68, γHV68, or MuHV-4), are B cell-tropic pathogens that each encode at least 12 microRNAs (miRNAs).
Emily R. Feldman +8 more
doaj +1 more source