Results 11 to 20 of about 5,135,710 (246)

Ganoderic acid loaded nano-lipidic carriers improvise treatment of hepatocellular carcinoma [PDF]

Drug Delivery, 2019
This work evaluates nano-lipid carrier of ganoderic acid (GA) and molecular docking on various cancer signaling pathways, an attempt to improve the hepatic condition associated with hepatic carcinoma (HCC) induced by diethyl-nitrosamine (DEN) in Wistar ...
Mahfoozur Rahman, Shareefa Abdullah Al-Ghamdi, Khalid S Alharbi, Sarwar Beg, Kalicharan Sharma, Firoz Anwar, Fahad A Al-Abbasi, Vikas Kumar   +7 more
doaj   +5 more sources

Synergistic Effect of Elicitors in Enhancement of Ganoderic Acid Production: Optimization and Gene Expression Studies [PDF]

Applied Food Biotechnology, 2015
Ganoderma lucidum is one of the most well-known fungi, and has many applications in medicine. Ganoderic acid is among the valuable secondary metabolites of Ganoderma lucidum, and responsible for the inhibition of the tumor cell growth and cancer ...
Motaharehsadat Heydarian, Ashrafalsadat Hatamian-Zarmi, Ghassem Amoabediny, Fatemeh Yazdian, Ali Doryab   +4 more
doaj   +4 more sources

Biotransformation of Ganoderic Acid A to 3-O-Acetyl Ganoderic Acid A by Soil-isolated Streptomyces sp. [PDF]

Fermentation, 2018
The medicinal fungus Ganoderma lucidum contains many bioactive triterpenoids, ganoderic acid A (GAA) being one of the major ones. The present study explored the microbial biotransformation of GAA, isolating 283 strains of soil actinomycetes and ...
Te-Sheng Chang, Horng-Huey Ko, Tzi-Yuan Wang, Chun-Hsien Lee, Jiumn-Yih Wu   +4 more
doaj   +2 more sources

Dual inhibitory potential of ganoderic acid A on GLUT1/3: computational and in vitro insights into targeting glucose metabolism in human lung cancer. [PDF]

RSC Adv
Human glucose transporters (GLUTs) facilitate the uptake of hexoses into cells. In cancer, the increased proliferation necessitates higher expression of GLUTs, with particular emphasis on GLUT1 and GLUT3.
Bashir MA, Abdalla M, Shao CS, Wang H, Bondzie-Quaye P, Almahi WA, Swallah MS, Huang Q.   +7 more
europepmc   +2 more sources

Cross Talk between GlAQP and NOX Modulates the Effects of ROS Balance on Ganoderic Acid Biosynthesis of Ganoderma lucidum under Water Stress [PDF]

Microbiology Spectrum, 2022
Water stress affects both the growth and development of filamentous fungi; however, the mechanisms underlying their response to water stress remain unclear.
Quanyu Zhu, Ang Ren, Juan Ding, Jian He, Mingwen Zhao, Ailiang Jiang, Xiaolin Zhou, Jieying Wang, Qin He   +8 more
doaj   +2 more sources

Ganoderic Acid A Alleviates Severe Acute Pancreatitis by Modulating Gut Homeostasis and Inhibiting TLR4-NLRP3 Signaling. [PDF]

J Agric Food Chem
Background Severe acute pancreatitis (SAP) manifests as a critical state marked by acute abdominal symptoms, often associated with intestinal barrier dysfunction, exacerbating SAP retroactively.
Zhang L, Wang K, Huang L, Deng B, Chen C, Zhao K, Wang W.   +6 more
europepmc   +2 more sources

Ganoderic Acid A and Its Amide Derivatives as Potential Anti-Cancer Agents by Regulating the p53-MDM2 Pathway: Synthesis and Biological Evaluation. [PDF]

Molecules, 2023
The mechanisms of action of natural products and the identification of their targets have long been a research hotspot. Ganoderic acid A (GAA) is the earliest and most abundant triterpenoids discovered in Ganoderma lucidum.
Jia Y, Li Y, Shang H, Luo Y, Tian Y.
europepmc   +2 more sources

Impact of Rifampin Induction on the Fermentation Production of Ganoderic Acids by Medicinal Mushroom Ganoderma lucidum [PDF]

Applied Food Biotechnology, 2016
Backgrounds and Objectives: Ganoderic acids are the most valuable secondary metabolites in Ganoderma lucidum traditional medicinal mushrooms, which have shown antitumor properties in many studies. However, application of ganoderic acids is limited due to
Fahimeh Nojoki, Ashrafalsadat Hatamian-Zarmi, Mohammad Mir-Drikvand, Bahman Ebrahimi-Hosseinzadeh, Zahra-begom Mokhtari-Hosseini, Saeed Kalantari-Dehaghi, Maryam Esmaeilifar   +6 more
doaj   +4 more sources

Ganoderic Acid Production via Aerial Co-cultivation of Ganoderma lucidum with Bacillus subtilis and Aspergillus niger Using Bubble Column Bioreactor [PDF]

Applied Food Biotechnology
Background and Objective: Ganoderma lucidum, with its medicinal characteristics, is one of the most beneficial fungi in traditional Asian medicine.
Soheil Kianirad, Dana Shakiba, Ashrafalsadat Hatamian, Zahra-Beagom Mokhtari-Hosseini, Hale Alvandi, Elham Ansari, Bahman Ebrahimi Hosseinzadeh   +6 more
doaj   +3 more sources

The Efficacy & Molecular Mechanisms of a Terpenoid Compound Ganoderic Acid C1 on Corticosteroid-Resistant Neutrophilic Airway Inflammation: In vivo and in vitro Validation. [PDF]

J Inflamm Res
Introduction Neutrophil predominant airway inflammation is associated with severe and steroid-resistant asthma clusters. Previously, we reported efficacy of ASHMI, a three-herb TCM asthma formula in a steroid-resistant neutrophil-dominant murine asthma ...
Wang ZZ, Li H, Maskey AR, Srivastava K, Liu C, Yang N, Xie T, Fu Z, Li J, Liu X, Sampson HA, Li XM.   +11 more
europepmc   +2 more sources