Phosphatidic acid directly activates mTOR and then regulates SREBP to promote ganoderic acid biosynthesis under heat stress in Ganoderma lingzhi. [PDF]
Commun BiolGanoderic acids (GAs), a class of secondary metabolites produced by the traditional medicinal mushroom Ganoderma, are a group of triterpenoids with superior biological activities.
Liu YN +6 more
europepmc +2 more sources
Ganoderic acid A attenuated hepatic impairment by down-regulating the intracellular JAK2-STAT3 signaling pathway in induced mushroom poisoning. [PDF]
Am J Transl ResBACKGROUND Mushroom poisoning is one of the most prominent public health problems. However, there is no special antidote so far. In the present study, we verified that Ganoderma lucidum may be an effective approach for treatment of acute mushroom ...
Xiao C, Huang G, Cao X, Li X.
europepmc +2 more sources
Ganoderic acid B’s influence towards the therapeutic window of trifluoperazine (TFP) [PDF]
African Health Sciences, 2015 Background: Ganoderic acid B is an important bioactive ingredient isolated from Ganoderma lucidum, and exhibits various pharmacological activities.Aims: To investigate the influence of Ganoderic acid B towards the therapeutic window of trifluoperazine ...
Guo, J, Liu, T, Liu, X, Ni, C
core +5 more sources
Glycosylation of Ganoderic Acid G by Bacillus Glycosyltransferases. [PDF]
Int J Mol Sci, 2021 Ganoderma lucidum is a medicinal fungus abundant in triterpenoids, its primary bioactive components. Although numerous Ganoderma triterpenoids have already been identified, rare Ganoderma triterpenoid saponins were recently discovered. To create novel Ganoderma saponins, ganoderic acid G (GAG) was selected for biotransformation using four Bacillus ...
Wu JY +4 more
europepmc +5 more sources
Increased production of ganoderic acids by overexpression of homologous farnesyl diphosphate synthase and kinetic modeling of ganoderic acid production in Ganoderma lucidum [PDF]
Microbial Cell Factories, 2019 Background Ganoderic acids (GAs), derived from the medicinal mushroom Ganoderma lucidum, possess anticancer and other important pharmacological activities.
Yu Fei, Na Li, De-Huai Zhang, Jun-Wei Xu
doaj +3 more sources
Ganoderic Acid A Alleviates OVA-Induced Asthma in Mice. [PDF]
Inflammation, 2021 AbstractThe aim of this study is to investigate the effects of ganoderic acid A (GAA) on OVA-induced asthma in mice. Mouse asthma model was established by ovalbumin (OVA) in vitro. Diff-Quik staining was used to observe the total numbers of cells and the number of classification cells in each group, and HE staining was used to observe lung inflammation
Lu X, Xu C, Yang R, Zhang G.
europepmc +4 more sources
Microbial Cell FactoriesGanoderic acids (GAs), recognized as significant triterpenoid bioactive components in Ganoderma lucidum, exhibit a broad spectrum of pharmacological activities, including immunomodulation, anti-cancer, and anti-aging properties. Despite their significant
Weidong Liu +7 more
semanticscholar +4 more sources
Ganoderic acid a derivative induces apoptosis of cervical cancer cells by inhibiting JNK pathway. [PDF]
Chin Herb MedWang M +7 more
europepmc +2 more sources
Shipin gongye ke-ji, 2023 The contents of polysaccharides, triterpenes, ganoderic acid A, ganoderic acid C1 and ganoderic acid F in Kangding Ganoderma leucocontextum were analyzed by pharmacopoeia and HPLC.
Boyu ZHU +8 more
doaj +1 more source
Journal of Fungi, 2022 The effects of oleic acid addition methods on the metabolic flux distribution of ganoderic acids R, S and T’s biosynthesis from Ganoderma lucidum were investigated.
Meng-Qiu Yan +9 more
doaj +1 more source