Results 51 to 60 of about 2,525,777 (194)

Alcohol Extracts From Ganoderma lucidum Delay the Progress of Alzheimer’s Disease by Regulating DNA Methylation in Rodents

Frontiers in Pharmacology, 2019
Age-related changes in methylation are involved in the occurrence and development of tumors, autoimmune disease, and nervous system disorders, including Alzheimer’s disease (AD), in elderly individuals; hence, modulation of these methylation changes may ...
Guoxiao Lai, Guoxiao Lai, Yinrui Guo, Diling Chen, Xiaocui Tang, Ou Shuai, Tianqiao Yong, Dongdong Wang, Chun Xiao, Gailian Zhou, Yizhen Xie, Burton B. Yang, Burton B. Yang, Qingping Wu   +13 more
doaj   +1 more source

Microbiome‐Derived Tryptophan Metabolites Regulate AhR Signaling to Restore Epithelial Barrier Integrity in Inflammatory Bowel Disease

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
The graphical abstract illustrates how microbiome‐derived indoles activate the aryl hydrocarbon receptor to restore the intestinal barrier. The picture contrasts the “leaky gut” state with the restored homeostasis achieved through AMPK, Nrf2, and IL‐22 signaling.
Mohammad Ali Mahdiabadi, Asma Moghaddam, Nafiseh Erfanian   +2 more
wiley   +1 more source

The Efficacy & Molecular Mechanisms of a Terpenoid Compound Ganoderic Acid C1 on Corticosteroid-Resistant Neutrophilic Airway Inflammation: In vivo and in vitro Validation. [PDF]

J Inflamm Res
Zhen-Zhen Wang,1– 3,* Hang Li,4,* Anish R Maskey,2,* Kamal Srivastava,2,5,* Changda Liu,6,* Nan Yang,2,5 Taoyun Xie,7 Ziyi Fu,8 Junxiong Li,9 Xiaohong Liu,10 Hugh A Sampson,6 Xiu-Min Li2,11 1Academy of Chinese Medical Science, Henan ...
Wang ZZ, Li H, Maskey AR, Srivastava K, Liu C, Yang N, Xie T, Fu Z, Li J, Liu X, Sampson HA, Li XM.   +11 more
europepmc   +2 more sources

Synergistic effect of Ganoderma lucidum Triterpenoids and biosynthesized Zinc Oxide nanoparticles against some dermatophytes [PDF]

Nanomedicine Research Journal
G. lucidum mushroom has been recorded in conventional medicine for more than 2000 years due to has several bioactive compounds including triterpenoids (GLTs).
Hasan Kareem, Alaa Mohsin Al-Araji
doaj   +1 more source

Clinical Efficacy and Mechanisms of ZiyuShuang, an Anti‐Skin Aging Formula Identified Through Network Medicine Framework Analysis

Journal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.
ABSTRACT Background Skin aging, a key aspect of physiological decline, markedly affects appearance, making strategies to delay it vital for quality of life. Materials and Methods We applied network medicine analysis to screen herbal medicines from the TCMSP database, yielding an anti‐skin aging formula, ZiYuShuang (ZYS).
Yingpeng Tong, Xiangmei Ni, Xinnan Jiang, Ru Zhang, Pengcheng Guo, Chunbo Feng, Jianxin Wang   +6 more
wiley   +1 more source

Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast

Nature Communications, 2022
AbstractType II ganoderic acids (GAs) produced by the traditional medicinal mushroom Ganoderma are a group of triterpenoids with superior biological activities. However, challenges in the genetic manipulation of the native producer, low level of accumulation in the farmed mushroom, the vulnerabilities of the farming-based supply chain, and the elusive ...
Wei Yuan, Chenjian Jiang, Qin Wang, Yubo Fang, Jin Wang, Meng Wang, Han Xiao   +6 more
openaire   +3 more sources

Postharvest Drying Techniques Regulate Secondary Metabolites and Anti-Neuroinflammatory Activities of Ganoderma lucidum

Molecules, 2021
Ganoderma lucidum extract is a potent traditional remedy for curing various ailments. Drying is the most important postharvest step during the processing of Ganoderma lucidum.
Nooruddin-bin Sadiq, Da-Hye Ryu, Jwa-Yeong Cho, A-Hyeon Lee, Dae-Geun Song, Banzragch Dorjsembe, Jin-Chul Kim, Je-Hyeong Jung, Chu-Won Nho, Muhammad Hamayun, Seung-Hoon Yang, Ho-Youn Kim   +11 more
doaj   +1 more source

Induction of apoptosis and ganoderic acid biosynthesis by cAMP signaling in Ganoderma lucidum [PDF]

Scientific Reports, 2017
AbstractApoptosis is an essential physiological process that controls many important biological functions. However, apoptosis signaling in relation to secondary metabolite biosynthesis in plants and fungi remains a mystery. The fungusGanoderma lucidumis a popular herbal medicine worldwide, but the biosynthetic regulation of its active ingredients ...
Bang-Jau You, Ni Tien, Miin-Huey Lee, Bo-Ying Bao, Yih-Shyuan Wu, Tsung-Chi Hu, Hong-Zin Lee   +6 more
openaire   +3 more sources

Function of ceramide synthases on growth, ganoderic acid biosynthesis and sphingolipid homeostasis in Ganoderma lucidum

, 2020
Lu, Xiaoxiao, Xie, Chunqin, Wang, Yunxiao, Liu, Yongnan, Han, Jing, Shi, Liang, Zhu, Jing, Yu, Hanshou, Ren, Ang, Zhao, Mingwen (2020): Function of ceramide synthases on growth, ganoderic acid biosynthesis and sphingolipid homeostasis in Ganoderma ...
Shi, Liang, Wang, Yunxiao, Zhao, Mingwen, Liu, Yongnan, Yu, Hanshou, Lu, Xiaoxiao, Han, Jing, Ren, Ang, Xie, Chunqin, Zhu, Jing   +9 more
core   +1 more source

Metabolism in Tumor: Mechanisms and Therapeutic Perspectives

MedComm, Volume 7, Issue 9, September 2026.
Tumor metabolic reprogramming converges on three hubs—the SREBP1/2–FASN–SCD1 lipogenic axis, the HIF‐1α–GLUT1–LDHA glycolytic axis, and the LDLR–SCARB1–LXR cholesterol system—which integrate transcriptional, epigenetic (histone lactylation, m6A), and microenvironmental inputs to generate metabolic plasticity, immune evasion, and therapy resistance ...
Jia‐Chen Cheng, Yi‐Xuan Hu, Xiang‐Chun Huang, Shan Jiang, Jie‐Lin Wang, Yang Zhao, Shuo Chen   +6 more
wiley   +1 more source