Results 61 to 70 of about 9,792 (169)

Influence of cultivation substrate on antioxidant activities and triterpenoid profiles of the fruiting body of Ganoderma lucidum

Frontiers in Nutrition
IntroductionThe fruiting body of Ganoderma lucidum has been believed to possess a wide range of therapeutic effects. There are two main methods for artificial cultivation of G.
Gelian Luo, Zhibin Pan, Zhibin Liu, Weiqing Cheng, Tingting Yu   +4 more
doaj   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Genetic engineering ofGanoderma lucidumfor the efficient production of ganoderic acids [PDF]

Bioengineered, 2015
Ganoderma lucidum is a well-known traditional medicinal mushroom that produces ganoderic acids with numerous interesting bioactivities. Genetic engineering is an efficient approach to improve ganoderic acid biosynthesis. However, reliable genetic transformation methods and appropriate genetic manipulation strategies remain underdeveloped and thus ...
Jun-Wei, Xu, Jian-Jiang, Zhong
openaire   +2 more sources

Impact of Rifampin Induction on the Fermentation Production of Ganoderic Acids by Medicinal Mushroom Ganoderma lucidum

Applied Food Biotechnology, 2016
Backgrounds and Objectives: Ganoderic acids are the most valuable secondary metabolites in Ganoderma lucidum traditional medicinal mushrooms, which have shown antitumor properties in many studies. However, application of ganoderic acids is limited due to
Fahimeh Nojoki, Ashrafalsadat Hatamian-Zarmi, Mohammad Mir-Drikvand, Bahman Ebrahimi-Hosseinzadeh, Zahra-begom Mokhtari-Hosseini, Saeed Kalantari-Dehaghi, Maryam Esmaeilifar   +6 more
doaj  

Improved ganoderic acids production in Ganoderma lucidum by wood decaying components [PDF]

Scientific Reports, 2017
AbstractGanoderma lucidumis a legendary Traditional Chinese Medicine (TCM) over a few thousands of years and one kind of its major active components are Ganoderic acids (GAs). GAs are largely produced in the mushroom primordium and fruiting body but much less in mycelium stage. However, little is known on the underlying regulatory mechanism.
Yanru Hu, Shakeel Ahmed, Jiawei Li, Biaobiao Luo, Zengyan Gao, Qiyun Zhang, Xiaohua Li, Xuebo Hu   +7 more
openaire   +2 more sources

Multi‐Omics Analysis Reveals the Potential Preventive Mechanism of Lactobacillus salivarius Li01 Against L‐Arginine‐Induced Acute Pancreatitis in Mice

Microbial Biotechnology, Volume 19, Issue 1, January 2026.
This study reveals that Lactobacillus salivarius Li01 alleviates acute pancreatitis by increasing gut Paramuribaculum. This modulation of the microbiota and its steroid hormone metabolites suppresses the pancreatic TNF signaling pathway, uncovering a protective ‘gut‐metabolism‐immunity’ axis.
Jiamin Duan, Jing Lou, Feiyu Wang, Huiyong Jiang, Longxian Lv, Hongwei Fu   +5 more
wiley   +1 more source

Ganoderic acid and its derivatives as cholesterol synthesis inhibitors.

Chemical and Pharmaceutical Bulletin, 1989
Oxygenated lanosterol derivatives, which were isolated from Ganoderma lucidum (Polyporaceae) or their derivatives obtained by chemical conversion, were tested for their effect on cholesterol biosynthesis from 24,25-dihydrolanosterol by rat hepatic subcellular 10,000 x g supernatant fraction.
KOMODA, Yasuo, SHIMIZU, Masato, SONODA, Yoshiko, SATO, Yoshihiro   +3 more
openaire   +3 more sources

Systemic Effect of Ganoderma lucidum Filtrate on Septoria Leaf Spot and Pycnidia Formation by Septoria lycopersici

Journal of Phytopathology, Volume 174, Issue 1, January/February 2026.
ABSTRACT This study aimed to evaluate the potential of the mycelial growth filtrate (MGF) from Ganoderma lucidum in providing systemic protection to tomato plants against Septoria lycopersici‐induced leaf spot and inhibiting the production of reproductive structures by the phytopathogen. In greenhouse experiments, foliar application of MGF at 40% (v/v)
Mycheli P. Cruz, Ricardo B. Felipini, Sergio M. Mazaro, Robson M. Di Piero   +3 more
wiley   +1 more source

Medicinal Plants and Lead Phytomolecules as Immunomodulators: An Updated Review

BioMed Research International, Volume 2026, Issue 1, 2026.
All therapeutic interventions aimed at modulating the immune response to pathogens, self‐antigens, carcinogens, or xenogeneic antigens are referred to as immunomodulation, which either prevents hyperactivation or restores the appropriate response of the immune system.
Gurdeep Singh, Vikas Sharma, Blessing Nnenna Udeh, Baisakhi Banerjee   +3 more
wiley   +1 more source

Ganoderic Acid A Alleviates High‐Fat Diet‐Induced Lipid Metabolism Disorders in Mice by Inhibiting Intestinal Farnesoid X Receptor

Food Frontiers, Volume 6, Issue 6, Page 3108-3121, November 2025.
Ganoderic acid A (GA) improved lipid metabolism disorders by inhibiting intestinal FXR. GA markedly suppressed the ileal intestinal FXR activity. Then, GA changed bile acid composition and upregulated hepatic Cyp7a1 mRNA through decreasing FXR target genes encoded protein levels.
Feng Lu, Shanshan Ju, Yi Ying, Jihan Liu, Chengfeng Yang, Min Li, Hong Zhou, Baoxue Yang   +7 more
wiley   +1 more source