Ganoderic Acid Production via Aerial Co-cultivation of Ganoderma lucidum with Bacillus subtilis and Aspergillus niger Using Bubble Column Bioreactor [PDF]
Applied Food BiotechnologyBackground and Objective: Ganoderma lucidum, with its medicinal characteristics, is one of the most beneficial fungi in traditional Asian medicine.
Soheil Kianirad +6 more
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Ganoderic acid A ameliorates non-alcoholic streatohepatitis (NASH) induced by high-fat high-cholesterol diet in mice. [PDF]
Exp Ther Med, 2022 Non-alcoholic steatohepatitis (NASH) is becoming a huge global health problem. Previous studies have revealed that ganoderic acids have hepatoprotective and hypocholesterolemic effects.
Zhu J, Ding J, Li S, Jin J.
europepmc +2 more sources
Ganoderic acid A attenuated hepatic impairment by down-regulating the intracellular JAK2-STAT3 signaling pathway in induced mushroom poisoning. [PDF]
Am J Transl ResBACKGROUND Mushroom poisoning is one of the most prominent public health problems. However, there is no special antidote so far. In the present study, we verified that Ganoderma lucidum may be an effective approach for treatment of acute mushroom ...
Xiao C, Huang G, Cao X, Li X.
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Ganoderic Acid A Promotes Amyloid-β Clearance (In Vitro) and Ameliorates Cognitive Deficiency in Alzheimer's Disease (Mouse Model) through Autophagy Induced by Activating Axl. [PDF]
Int J Mol Sci, 2021 Alzheimer’s disease (AD) is thought to be caused by amyloid-β (Aβ) accumulation in the central nervous system due to deficient clearance. The aim of the present study was to investigate the effect of ganoderic acid A (GAA) on Aβ clearance in microglia ...
Qi LF, Liu S, Liu YC, Li P, Xu X.
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A New Triterpenoid Glucoside from a Novel Acidic Glycosylation of Ganoderic Acid A via Recombinant Glycosyltransferase of Bacillus subtilis [PDF]
Molecules, 2019 Ganoderic acid A (GAA) is a bioactive triterpenoid isolated from the medicinal fungus Ganoderma lucidum. Our previous study showed that the Bacillus subtilis ATCC (American type culture collection) 6633 strain could biotransform GAA into compound (1 ...
Te-Sheng Chang +5 more
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A novel approach to enhancing ganoderic acid production by Ganoderma lucidum using apoptosis induction. [PDF]
PLoS ONE, 2013 Ganoderma lucidum is one of most widely used herbal medicine and functional food in Asia, and ganoderic acids (GAs) are its active ingredients. Regulation of GA biosynthesis and enhancing GA production are critical to using G.
Bang-Jau You +7 more
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Journal of Physics: Conference SeriesAnalytical approaches with the features of easy manipulation, cost-effectiveness, and miniature are needed for practice-oriented point-of-care diagnostics.
Wenwei Li, Yao Xie, Axin Liang
semanticscholar +2 more sources
Ganoderic Acid A Alleviates OVA-Induced Asthma in Mice. [PDF]
Inflammation, 2021 AbstractThe aim of this study is to investigate the effects of ganoderic acid A (GAA) on OVA-induced asthma in mice. Mouse asthma model was established by ovalbumin (OVA) in vitro. Diff-Quik staining was used to observe the total numbers of cells and the number of classification cells in each group, and HE staining was used to observe lung inflammation
Lu X, Xu C, Yang R, Zhang G.
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Frontiers in PharmacologyGanoderic acid A (GAA), a major bioactive triterpenoid from Ganoderma lucidum, is known for its anti-inflammatory effects; however, its precise molecular targets in sepsis-related liver injury (SRLI) remain unclear.
Hong Hu +9 more
doaj +2 more sources
Ganoderic Acid A targeting leucine-rich repeat kinase 2 involved in Parkinson's disease-A computational study. [PDF]
Aging Med (Milton), 2023 AbstractObjectiveThis study aims to find the most promising Ganoderma lucidium targeting LRRK2 involved in PD.MethodsFirst ADMET analysis was performed for five compounds followed by molecular docking of each compound. Then, we perform molecular dynamics simulation of all five compounds and finally MMGBSA of all five compounds.ResultsBased on molecular
Ahmad F.
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