Results 51 to 60 of about 701,063 (234)

Tissue invasion and metastasis: molecular, biological and clinical perspectives [PDF]

, 2015
Cancer is a key health issue across the world, causing substantial patient morbidity and mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to distant sites, with metastatic diseases accounting for a vast ...
Amedei, A., Amin, A., Ashraf, S., Dhawan, P., et al., Fujii, H., Georgakilas, A., Gieseler, F., Honoki, K., Jiang, W., Katoh, M., Niccolai, E., Prince, M., Sanders, A., Sarkar, M., Sliva, D., Spano, D., Subbarayan, P., Thompson, S., Ungefroren, H., Zollo, M.   +20 more
core   +1 more source

The mushroom Ganoderma lucidum suppresses breast-to-lung cancer metastasis through the inhibition of pro-invasive genes. [PDF]

, 2014
Breast cancer metastasis is one of the major reasons for the high morbidity and mortality of breast cancer patients. In spite of surgical interventions, chemotherapy, radiation therapy and targeted therapy, some patients are considering alternative ...
Jedinak, Andrej, Jiang, Jiahua, Loganathan, Jagadish, Nakshatri, Harikrishna, Sandusky, George E., Sliva, Daniel, Smith, Amanda, Thyagarajan-Sahu, Anita   +7 more
core   +3 more sources

New Triterpenoid from Novel Triterpenoid 15-O-Glycosylation on Ganoderic Acid A by Intestinal Bacteria of Zebrafish

Molecules, 2018
Functional bacteria that could biotransform triterpenoids may exist in the diverse microflora of fish intestines. Ganoderic acid A (GAA) is a major triterpenoid from the medicinal fungus Ganoderma lucidum.
Te-Sheng Chang, Chien-Min Chiang, Tzi-Yuan Wang, Chun-Hsien Lee, Yu-Wen Lee, Jiumn-Yih Wu   +5 more
doaj   +1 more source

Effect of Methyl Jasmonate Elicitation on Triterpene Production and Evaluation of Cytotoxic Activity of Mycelial Culture Extracts of Ganoderma applanatum (Pers.) Pat.

Plants, 2023
Abiotic elicitation, a well-known strategy in mushroom biotechnology, promotes increased accumulation of secondary metabolites in mycelial cultures. The study aimed the effects of methyl jasmonate (MeJA) on the production of triterpenes in submerged ...
Katarzyna Sułkowska-Ziaja, Agnieszka Galanty, Agnieszka Szewczyk, Paweł Paśko, Katarzyna Kała, Anna Apola, Irma Podolak, Bożena Muszyńska   +7 more
doaj   +1 more source

Delivering natural products and biotherapeutics to improve drug efficacy [PDF]

, 2017
Due to the increasing problem of drug resistance, new and improved medicines are required. Natural products and biotherapeutics offer a vast resource for new drugs; however, challenges, including the cost and time taken for traditional drug discovery ...
Al Qaraghuli, Mohammed M., Alsaadi, Manal, Alzahrani, Abdullah R., Ferro, Valerie A., Niwasabutra, Kanidta, Obeid, Mohammad A.   +5 more
core   +1 more source

Target specific inhibition of West Nile virus envelope glycoprotein and methyltransferase using phytocompounds: an in silico strategy leveraging molecular docking and dynamics simulation

Frontiers in Microbiology, 2023
Mosquitoes are the primary vector for West Nile virus, a flavivirus. The virus’s ability to infiltrate and establish itself in increasing numbers of nations has made it a persistent threat to public health worldwide.
Shopnil Akash, Imren Bayıl, Md. Anisur Rahman, Nobendu Mukerjee, Nobendu Mukerjee, Swastika Maitra, Md. Rezaul Islam, Sanchaita Rajkhowa, Arabinda Ghosh, Sami A. Al-Hussain, Magdi E. A. Zaki, Vikash Jaiswal, Sanjit Sah, Sanjit Sah, Joshuan J. Barboza, Ranjit Sah, Ranjit Sah, Ranjit Sah   +17 more
doaj   +1 more source

In Vitro Antitumor Effects of the Cold-Water Extracts of Mediterranean Species of Genus Pleurotus (Higher Basidiomycetes) on Human Colon Cancer Cells [PDF]

, 2014
The aim of the present study was to evaluate whether the cold-water extract of Pleurotus eryngii var. ferulae (CWE-Pef) and Pleurotus nebrodensis (CWE-Pn), two of the most prized wild and cultivated edible mushrooms can affect the tumour phenotype of ...
Alessandro, R., Cannizzaro, A., DE LEO, G., FLUGY PAPE', A., Fontana, S., Gargano, M., Saitta, A., Schillaci, O., Venturella, G.   +8 more
core   +1 more source

Alcohol Extracts From Ganoderma lucidum Delay the Progress of Alzheimer’s Disease by Regulating DNA Methylation in Rodents

Frontiers in Pharmacology, 2019
Age-related changes in methylation are involved in the occurrence and development of tumors, autoimmune disease, and nervous system disorders, including Alzheimer’s disease (AD), in elderly individuals; hence, modulation of these methylation changes may ...
Guoxiao Lai, Guoxiao Lai, Yinrui Guo, Diling Chen, Xiaocui Tang, Ou Shuai, Tianqiao Yong, Dongdong Wang, Chun Xiao, Gailian Zhou, Yizhen Xie, Burton B. Yang, Burton B. Yang, Qingping Wu   +13 more
doaj   +1 more source

Identification of potential neuroprotective compound from Ganoderma lucidum extract targeting microtubule affinity regulation kinase 4 involved in Alzheimer's disease through molecular dynamics simulation and MMGBSA

Aging Medicine, 2023
Objective Alzheimer's disease (AD) is one of the most prevalent neurological ailments, affecting around 50 million individuals globally. The condition is characterized by nerve cell damage due to the formation of amyloid‐beta plaques and neurofibrillary ...
Faizan Ahmad, Gagandeep Singh, Hemant Soni, Smriti Tandon   +3 more
doaj   +1 more source

Neurite outgrowth stimulatory effects of culinary-medicinal mushrooms and their toxicity assessment using differentiating Neuro-2a and embryonic fibroblast BALB/3T3 [PDF]

, 2013
BACKGROUND: Mushrooms are not only regarded as gourmet cuisine but also as therapeutic agent to promote cognition health. However, little toxicological information is available regarding their safety.
Chia-Wei Phan, Kah-Hui Wong, Murali Naidu, Pamela David, Vikineswary Sabaratnam   +4 more
core   +1 more source