Results 221 to 230 of about 2,836,933 (367)

Anti-angiogenesis therapy and gap junction inhibition reduce MDA-MB-231 breast cancer cell invasion and metastasis in vitro and in vivo [PDF]

, 2015
Kazem Zibara, Zahraa Awada, Leila Dib, Jamal El Saghir, Sara Al‐Ghadban, Aida Ibrik, Nabil El Zein, Marwan El‐Sabban   +7 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Intercellular diffusion of cyclic nucleotides followed by gap junction closure restarts meiosis in mouse preovulatory follicles. [PDF]

Proc Natl Acad Sci U S A
Nakashima IF, Zhong H, Nikolaev VO, Owen CM, Yee SP, Jaffe LA, Egbert JR.   +6 more
europepmc   +1 more source

Expression and Regulation of Gap Junction Proteins in Human Cholangiocytes by Excretory-Secretory Products of Clonorchis sinensis and

, 2013
김은민
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling. [PDF]

Cell
Krolak T, Kaplan L, Navas K, Chen L, Birmingham A, Ryvkin D, Izsa V, Powell M, Wu Z, Deverman BE, Gu C.   +10 more
europepmc   +1 more source

Investigation of the gap junction intercellular communication between embryonic stem cells and connexin-43 over-expressing human foreskin fibroblasts and HeLa cells

, 2011
Yee-kwan Li
openalex   +1 more source

Gap junction reduction in cardiomyocytes following transforming growth factor-β treatment and Trypanosoma cruzi infection [PDF]

, 2009
Mariana Caldas Waghabi, Robson Coutinho‐Silva, Jean‐Jacques Feige, Maria de Lourdes Higuchi, David L. Becker, Geoffrey Burnstock, Tânia Cremonini de Araújo-Jorge   +6 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Reduced gap junction coupling amplifies the effects of cardiomyocyte variability and destabilizes the heartbeat. [PDF]

Physiol Rep
Jæger KH, Louch WE, Tveito A.
europepmc   +1 more source