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Nonredundant Gap Junction Functions
Physiology, 2003The need for molecular heterogeneity of gap junction channel proteins in vivo has been enigmatic. Recently, functional replacement of one channel gene with another in mice and flies has revealed that cellular health depends not simply on gap junction communication but also requires the correct type of intercellular channel subunit.
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Gap junction proteins form specialized intercellular communication channels, including electrical synapses, that regulate cellular metabolism and signaling. We present a molecular inventory of the gap junction proteins-innexins (INX-like) in ctenophores, focusing on two reference species, Pleurobrachia bachei and Mnemiopsis leidyi.
Andrea B, Kohn, Leonid L, Moroz
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Andrea B, Kohn, Leonid L, Moroz
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Tight Junctions and Gap Junctions
2010Tight junctions have several major functions. They seal the intercellular space in epithelial and endothelial cell layers and prevent free paracellular passage of substances. They determine the polarity of epithelial cells by creating a boundary between the apical domain of the plasma membrane and the basolateral domain and prevent diffusion of lipids ...
Margit Pavelka, Jürgen Roth
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Gap Junctions as Electrical Synapses
Journal of Neurocytology, 1996Gap junctions are the morphological substrate of one class of electrical synapse. The history of the debate on electrical vs. chemical transmission is instructive. One lesson is that Occam's razor sometimes cuts too deep; the nervous system does its operations in a number of different ways and a unitarian approach can lead one astray.
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
1993
One of the main avenues by which cells communicate with each other is through transmembranous channels which span the extracellular space, thereby allowing the direct transfer of small molecules and ions. The size range of admitted molecules allows the diffusion of current-carrying ions such as K+, Na+, Cl-, and second messenger molecules such as cAMP,
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One of the main avenues by which cells communicate with each other is through transmembranous channels which span the extracellular space, thereby allowing the direct transfer of small molecules and ions. The size range of admitted molecules allows the diffusion of current-carrying ions such as K+, Na+, Cl-, and second messenger molecules such as cAMP,
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