Results 81 to 90 of about 2,836,933 (367)

Connexins: a myriad of functions extending beyond assembly of gap junction channels

Cell Communication and Signaling, 2009
Connexins constitute a large family of trans-membrane proteins that allow intercellular communication and the transfer of ions and small signaling molecules between cells.
Hashem A. Dbouk, Rana M Mroue, Marwan E El-Sabban, R. Talhouk   +3 more
semanticscholar   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Spatial noise in coupling strength and natural frequency within a pacemaker network; consequences for development of intestinal motor patterns according to a weakly coupled phase oscillator model

Frontiers in Neuroscience, 2016
Pacemaker activities generated by networks of interstitial cells of Cajal (ICC), in conjunction with the enteric nervous system, orchestrate most motor patterns in the gastrointestinal tract.
Sean P Parsons, Jan D. Huizinga
doaj   +1 more source

Pannexin channels are not gap junction hemichannels

Channels, 2011
Pannexins, a class of membrane channels, bear significant sequence homology with the invertebrate gap junction proteins, innexins, and more distant similarities in their membrane topologies and pharmacological sensitivities with the gap junction proteins,
G. Sosinsky, D. Boassa, R. Dermietzel, H. Duffy, D. Laird, B. MacVicar, C. Naus, S. Penuela, E. Scemes, D. Spray, Roger J. Thompson, Hong-Bo Zhao, G. Dahl   +12 more
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Why strengthening gap junctions may hinder action potential propagation

Frontiers in Applied Mathematics and Statistics
Gap junctions are channels in cell membranes allowing ions to pass directly between cells. They are found throughout the body, including heart myocytes, neurons, and astrocytes. In cardiac tissue and throughout the nervous system, an action potential (AP)
Erin Munro Krull, Christoph Börgers
doaj   +1 more source

Gap junction-mediated import of microRNA from bone marrow stromal cells can elicit cell cycle quiescence in breast cancer cells.

Cancer Research, 2011
Bone marrow (BM) metastasis of breast cancer (BC) can recur even decades after initial diagnosis and treatment, implying the long-term survival of disseminated cancer cells in a dormant state.
P. Lim, S. A. Bliss, Shyam A. Patel, M. Taborga, M. Dave, L. Gregory, Steven J. Greco, M. Bryan, Prem S. Patel, P. Rameshwar   +9 more
semanticscholar   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells. [PDF]

, 1997
Oleamide is a sleep-inducing lipid originally isolated from the cerebrospinal fluid of sleep-deprived cats. Oleamide was found to potently and selectively inactivate gap junction-mediated communication between rat glial cells.
Cao, Charles, Charles, Cornell-Bell, Cravatt, Cravatt, Davidson, Dewey, El-Fouly, Enkvist, Enomoto, Feller, Finkbeiner, Fluri, Frame, Guan, Guan, Hansen, Hassinger, Hirschi, Jalife, Kumar, Kumar, Mege, Miller, Musil, Musil, Nedergaard, Neyton, Osipchuk, Palmer, Parpura, Suter, Veenstra, Venance, Warner   +35 more
core   +2 more sources

Gap junctions in C. elegans [PDF]

Frontiers in Physiology, 2014
As in other multicellular organisms, the nematode Caenorhabditis elegans uses gap junctions to provide direct cell-to-cell contact. The nematode gap junctions are formed by innexins (invertebrate analogs of the connexins); a family of proteins that surprisingly share no primary sequence homology, but do share structural and functional similarity with ...
Karina eSimonsen, Karina eSimonsen, Donald eMoerman, Christian C. Naus   +3 more
openaire   +3 more sources