Results 111 to 120 of about 217,733 (290)

Cancer Connectors: Connexins, Gap Junctions, and Communication

Frontiers in Oncology, 2018
Despite concerted clinical and research efforts, cancer is a leading cause of death worldwide. Surgery, radiation, and chemotherapy have remained the most common standard-of-care strategies against cancer for decades.
Maksim Sinyuk, Maksim Sinyuk, Erin E. Mulkearns-Hubert, Ofer Reizes, Ofer Reizes, Ofer Reizes, Ofer Reizes, Justin Lathia, Justin Lathia, Justin Lathia, Justin Lathia, Justin Lathia   +11 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Regulation of gap junctions by protein phosphorylation

Brazilian Journal of Medical and Biological Research, 1998
Gap junctions are constituted by intercellular channels and provide a pathway for transfer of ions and small molecules between adjacent cells of most tissues.
J.C. Sáez, A.D. Martínez, M.C. Brañes, H.E. González   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Fabrication and characterization of high current-density, submicron, NbN/MgO/NbN tunnel junctions [PDF]

At near-millimeter wavelengths, heterodyne receivers based on SIS tunnel junctions are the most sensitive available. However, in order to scale these results to submillimeter wavelengths, certain device properties should be scaled.
Judas, A. J., Leduc, Henry G., Stern, J. A.   +2 more
core   +1 more source

Majorana fermions at odd junctions in a wire network of ferromagnetic impurities

, 2016
We consider a wire network of ferromagnetic impurities on the surface of an $s$-wave superconductor with strong Rashba spin-orbit interaction. Within the topological phase, zero-energy Majorana fermions appear at wire end-points as well as at junctions ...
Björnson, Kristofer, Black-Schaffer, Annica M.   +1 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Modulation of connexin 43 in viral infections

Tumour Virus Research
Connexins are essential for intercellular communication through gap junctions and the maintenance of cellular and tissue homeostasis. Connexin 43 (Cx43) is the most ubiquitously expressed connexin. As well as regulating homeostasis, Cx43 hemichannels and
Harry Scott, Patricia E. Martin, Sheila V. Graham   +2 more
doaj   +1 more source

Subgap anomaly and above-energy-gap structure in chains of diffusive SNS junctions

, 2002
We present the results of low-temperature transport measurements on chains of superconductor--normal-constriction--superconductor (SNS) junctions fabricated on the basis of superconducting PtSi film.
A. F. Andreev, A. Frydman, B. J. Wees van, B. Pannetier, D. R. Islamov, G. E. Blonder, H. Courtois, J. Kutchinsky, M. Octavio, P. Charlat, S. N. Artemenko, T. Hoss, T. I. Baturina, T. M. Klapwijk, W. Eisenmenger, W. M. Huffelen van, Yu. V. Nazarov, Z. D. Kvon   +17 more
core   +1 more source