Results 111 to 120 of about 229,376 (344)

High efficiency switching using graphene based electron 'optics'

open access: yes, 2011
The absence of a band-gap in graphene limits the gate modulation of its electron conductivity, both in regular graphene as well as in PN junctions, where electrostatic barriers prove transparent to Klein tunneling.
Ghosh, Avik, Sajjad, Redwan
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Regulation of gap junction channels and hemichannels by phosphorylation and redox changes: a revision [PDF]

open access: gold, 2016
Kristin Pogoda   +3 more
openalex   +1 more source

The role of gap junctions in cell death and neuromodulation in the retina

open access: gold, 2021
Tamás Kovács‐Öller   +5 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Regulation of gap junctions by protein phosphorylation

open access: yesBrazilian Journal of Medical and Biological Research, 1998
Gap junctions are constituted by intercellular channels and provide a pathway for transfer of ions and small molecules between adjacent cells of most tissues.
J.C. Sáez   +3 more
doaj   +1 more source

Gap junction reduction in cardiomyocytes following transforming growth factor-β treatment and Trypanosoma cruzi infection [PDF]

open access: diamond, 2009
Mariana Caldas Waghabi   +6 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Anomalous Behavior near T_c and Synchronization of Andreev Reflection in Two-Dimensional Arrays of SNS Junctions

open access: yes, 2006
We have investigated low-temperature transport properties of two-dimensional arrays of superconductor--normal-metal--superconductor (SNS) junctions. It has been found that in two-dimensional arrays of SNS junctions (i) a change in the energy spectrum ...
A. E. Plotnikov   +16 more
core   +1 more source

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