Results 211 to 220 of about 229,376 (344)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

The Role of Connexin 36 Gap Junctions in Retinal Ganglion Cell Death After Corneal Alkali Burns. [PDF]

Invest Ophthalmol Vis Sci
Qiu C, Zhang T, Wang Q, Yang K, So C, Pan F.   +5 more
europepmc   +1 more source

Gap junctions mediate discrete regulatory steps during fly spermatogenesis. [PDF]

PLoS Genet, 2022
Pesch YY, Dang V, Fairchild MJ, Islam F, Camp D, Kaur P, Smendziuk CM, Messenberg A, Carr R, McFarlane CR, Musso PY, Van Petegem F, Tanentzapf G.   +12 more
europepmc   +1 more source

Cellular Interaction of Integrin α3β1 with Laminin 5 Promotes Gap Junctional Communication [PDF]

, 1998
Paul D. Lampe, Beth P. Nguyen, Susana G. Gil, Marcia L. Usui, John E. Olerud, Yoshikazu Takada, William G. Carter   +6 more
openalex   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Extracellular vesicles released by glioblastoma cancer cells drive tumor invasiveness via Connexin-43 gap junctions. [PDF]

Neuro Oncol
Tamborini M, Ribecco V, Stanzani E, Sironi A, Tambalo M, Franzone D, Florio E, Fraviga E, Saulle C, Gagliani MC, Pizzocri M, Mattioli M, Cortese K, Jiang JX, Martano G, Politi LS, Riva M, Pessina F, Pozzi D, Lodato S, Passoni L, Matteoli M.   +21 more
europepmc   +1 more source

Nerve Structure-Function: Unusual Structural Details and Unmasking of Sulfhydryl Groups by Electrical Stimulation or Asphyxia in Axon Membranes and Gap Junctions. [PDF]

Int J Mol Sci, 2023
Peracchia C.
europepmc   +1 more source

Gap junctional coupling between retinal amacrine and ganglion cells underlies coherent activity integral to global object perception

, 2017
Kaushambi Roy, Sandeep Kumar, Stewart A. Bloomfield   +2 more
openalex   +2 more sources

The C-terminus of connexin43 adopts different conformations in the Golgi and gap junction as detected with structure-specific antibodies [PDF]

, 2007
Gina E. Sosinsky, Joell L. Solan, Guido Gaietta, Lucy Ngan, Grace J. Lee, Mason Mackey, Paul D. Lampe   +6 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source