Results 191 to 200 of about 229,376 (344)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis. [PDF]

Nat Commun
Williams J, Camarda R, Malkov S, Zimmerman LJ, Manning S, Aran D, Beardsley A, Van de Mark D, Nakagawa R, Chen Y, Berdan C, Louie SM, Mahieu C, Superville D, Winkler J, Willey E, Hutchins EJ, Gagnon JD, Avsaroglu SK, Shinoda K, Gruner M, Nishida H, Ansel KM, Werb Z, Nomura DK, Kajimura S, Butte AJ, Sanders ME, Liebler DC, Rugo HS, Krings G, Shepherd JA, Goga A.   +32 more
europepmc   +1 more source

Starburst amacrine cells amplify optogenetic visual restoration through gap junctions. [PDF]

Mol Ther Methods Clin Dev, 2023
Katada Y, Kunimi H, Serizawa N, Lee D, Kobayashi K, Negishi K, Okano H, Tanaka KF, Tsubota K, Kurihara T.   +9 more
europepmc   +1 more source

Fusion of GFP to the Carboxyl Terminus of Connexin43 Increases Gap Junction Size in HeLa Cells [PDF]

, 2003
Andrew W. Hunter, Jane Jourdan, Robert G. Gourdie   +2 more
openalex   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Connexin 36-mediated gap junctions contribute to fine odour discrimination and late-phase excitation of mitral cells in the mouse olfactory bulb. [PDF]

J Physiol
Kuruppath P, Jones ST, Pouille F, Ramirez-Gordillo D, Restrepo D, Schoppa NE.   +5 more
europepmc   +1 more source

Functional Roles of Connexins and Gap Junctions in Osteo-Chondral Cellular Components. [PDF]

Int J Mol Sci, 2023
Zappalà A, Romano IR, D'Angeli F, Musumeci G, Lo Furno D, Giuffrida R, Mannino G.   +6 more
europepmc   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Gap Junctions [PDF]

, 2008
openaire   +2 more sources

Hidden Structures: Gap Junctions, the Claustrum, and Anesthesia. [PDF]

Anesth Analg
Bosinski CR, Connor CW.
europepmc   +1 more source