Results 171 to 180 of about 229,376 (344)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The roles of connexins and gap junctions in the progression of cancer. [PDF]

Cell Commun Signal, 2023
Zhou M, Zheng M, Zhou X, Tian S, Yang X, Ning Y, Li Y, Zhang S.   +7 more
europepmc   +1 more source

Characterization of a variant of gap junction protein α8 identified in a family with hereditary cataract

, 2017
Debbie S. Kuo, Jared T. Sokol, Peter J. Minogue, Viviana M. Berthoud, Anne Slavotinek, Eric C. Beyer, Douglas B. Gould   +6 more
openalex   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Connexin 43 across the Vasculature: Gap Junctions and Beyond. [PDF]

J Vasc Res, 2023
Sedovy MW, Leng X, Leaf MR, Iqbal F, Payne LB, Chappell JC, Johnstone SR.   +6 more
europepmc   +1 more source

Desmosomal Regulation of Gap Junction Dynamics and Cellular Contractility via Small GTPases: Implications for Cardiocutaneous Disease

, 2018
Chen Yuan Kam
openalex   +1 more source

Formation of functional gap junctions in amniotic fluid‐derived stem cells induced by transmembrane co‐culture with neonatal rat cardiomyocytes [PDF]

, 2013
Jennifer P. Connell, Emily Augustini, Kenneth J. Moise, Anthony J. Johnson, Jeffrey G. Jacot   +4 more
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Role of Gap Junctions Dysfunction in the Development of Cataracts: From Loss of Cell-to-Cell Transfer to Blurred Vision-Review. [PDF]

Bioelectricity, 2023
Ek-Vitorin JF, Jiang JX.
europepmc   +1 more source

Gap Junctions with Varied Permeability Properties Establish Cell-Type Specific Communication Pathways in the Rat Seminiferous Epithelium1 [PDF]

, 2002
Michael S. Risley, Ignatius P. Tan, Jeanne Farrell   +2 more
openalex   +1 more source